Épidémiologie des fentes labio-palatines : expérience du Registre de malformations congénitales d’Alsace entre 1995 et 2006

Doray, Bérénice; Badila-Timbolschi, D.; Schaefer, Eric; Fattori, Daniela; Monga, Ben; Dott, B; Favre, R; Kohler, Maxie; Nisand, I.; Viville, B.; Kauffmann, I.; Bruant-Rodier, C.; Grollemund, Bruno; Rinkenbach, Renaud; Astruc, Dominique; Gasser, Bernard; Lindner, V.; Marcellin, Luc; Flori, E.; Girard-Lemaire, Françoise; Dollfus, Hélène

doi:10.1016/j.arcped.2012.07.002

Cited by 32 publications

(22 citation statements)

References 25 publications

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“…Our result, however, was lower than in some reports from the Middle East and Asia where [20] found a frequency of 43.3% in Jordan, [2] reported 14.8% in India; [3, 4] reported 17.8 and 21.6% in Iran, respectively. Furthermore, our rates of associated malformations were even lower than those reported from Europe (29–59.2%) [13, 15, 21] and Latin America (31.4–48.4%) [5, 8]. The distribution of clefts worldwide are thus associated with geography, race, and ethnicity [22–25], suggesting that the aforementioned factors may also influence the distribution of congenital malformations associated with clefts, which may explain the differences between studies.…”

Section: Discussioncontrasting

confidence: 86%

“…Our result also differed from those by [11, 14], who reported a predominance of females (sex ratio of 0.8 and 0.9 male: female, respectively) with malformations, largely associated with cleft palate. The published data, however, indicate a predominance of boys with cleft lips with or without cleft palates [15, 18, 22, 24] and of girls with cleft palates [2, 4, 5]. …”

Section: Discussionmentioning

confidence: 99%

“…The medical conditions associated with OFCs are not negligible and therefore must be identified and managed to avoid jeopardising cleft repair because of anaesthetic and/or surgical complications [9, 10]. Congenital malformations associated with OFCs have been well described around the world [2, 8, 11–15]; however, in developing African countries, available data are scarce. In Burkina Faso, particularly, to our knowledge, no data is available on the morbidities associated with OFCs.…”

Section: Introductionmentioning

confidence: 99%

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Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso

et al. 2017

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BackgroundOrofacial clefts are usually isolated cases but can be associated with other congenital malformations that are either recognised or unrecognised syndromes. The reported prevalence and pattern of such associated malformations, however, vary among studies. Objectives: To assess the frequencies and aetiologies of congenital malformations and associated medical conditions in children with orofacial clefts in Burkina Faso (Western Africa).MethodsA retrospective descriptive study was carried out at the El Fateh-Suka Clinic in Ouagadougou, Burkina Faso. All children who attended surgery for the repair of a cleft lip and/or palate were included in this study.ResultsThe frequency of congenital malformations associated with cleft lip and/or palate was 39/185 (21.1%). In the group with multiple congenital malformations of unknown origin (34 patients; 18.4%), 66.7% had cleft lip and palate, followed by isolated cleft lip (27.4%) and isolated cleft palate (5.9%). The digestive system (35.3%), the musculoskeletal system (19.6%), and eye, ear, face, and neck (15.7%) were the most affected systems. In the group of syndromic malformations (five patients; 2.7%), amniotic band syndrome (one patient), Van der Woode syndrome (one patient), Goltz syndrome (one patient), and holoprosencephaly (two patients) were identified. Medical conditions included anaemia (39.4%), infections (9.2%), malnutrition (7.5%), and haemoglobinopathies (4.3%).ConclusionsCongenital malformations and medical co-morbidities were frequent in children with OFCs. Further studies and a National Malformations Registry are needed to improve the comprehension of OFCs in Burkina Faso.

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Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso

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“…En France, elles concernent entre 1,75 et 2,1 pour 1000 enfants nés vivants [2,3]. Elles constituent un groupe hétérogène.…”

Section: Introductionunclassified

“…Cependant, même au sein des séries européennes, il persiste une grande variabilité dans la fréquence de ces associations malformatives. [3]. Notre étude avait pour objectif de préciser la distribution des fentes labiales et palatines isolées, associées à d'autres malformations et syndromiques.…”

Section: Introductionunclassified

Épidémiologie des malformations associées aux fentes labiales et palatines à propos d’une étude rétrospective de 324 cas

Bérail

Lauwers

Noirrit‐Esclassan

et al. 2015

Archives de Pédiatrie

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Ectodermal Dysplasias

Itin

2016

Rook's Textbook of Dermatology, Ninth Edition

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Ectodermal dysplasias, a large group of heterogeneous heritable conditions, are characterized by congenital defects in two or more ectodermal structures, involving at least one in the hair (trichodysplasia), teeth (dental defects), nails (onychodysplasia) or sweat glands (hypohidrosis). Of the approximately 220 different ectodermal dysplasias, about 80 have been identified at the molecular level with the identification of the causative genes. Recent evidence implicates genetic defects in different key pathways orchestrating ectodermal organogenesis.

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Épidémiologie des fentes labio-palatines : expérience du Registre de malformations congénitales d’Alsace entre 1995 et 2006

Cited by 32 publications

References 25 publications

Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso

Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso

Épidémiologie des malformations associées aux fentes labiales et palatines à propos d’une étude rétrospective de 324 cas

Ectodermal Dysplasias

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