Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso

Nagalo, Kisito; Ouédraogo, Issoufou; Laberge, Jean-Martin; Caouette‐Laberge, Louise; Turgeon, Julie

doi:10.1186/s12887-017-0833-9

Cited by 13 publications

(17 citation statements)

References 31 publications

(74 reference statements)

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“…20 A considerable number of associated comorbidities were found in the studied patients, especially anemia, followed by respiratory problems and cardiovascular diseases. These findings are in line with those observed by Dvivedi and Dvivedi, 21 who identified anemia in most of the 4,657 CL/P cases studied in India, 21 and by Nagalo et al, 22 who found anemia as the most frequent comorbidity in 185 children with CL/P, followed by respiratory infections in Western Africa. The same results were obtained by Kulkarni et al (2013).…”

Section: Discussionsupporting

confidence: 91%

Risk factors and comorbidities in Brazilian patients with orofacial clefts

et al. 2018

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Considering that environmental risk factors substantially contribute to the etiology of orofacial clefts and that knowledge about the characteristics and comorbidities associated with oral clefts is fundamental to promoting better quality of life, this study aimed to describe the risk factors, main characteristics, and comorbidities of a group of patients with cleft lip and/or cleft palate (CL/P) from Rio Grande do Norte (RN), Brazil. Data were obtained from 173 patients with CL/P using a form from the Brazilian database on Orofacial Clefts. Most patients were male with cleft lip and palate and had a normal size and weight at birth; presented few neonatal intercurrent events; and had anemia and respiratory and cardiovascular diseases as main associated comorbidities. They also required timely surgical rehabilitation and multidisciplinary care to stimulate their neuropsychomotor development. In addition, a high frequency of familial recurrence and of parental consanguinity was evidenced in the studied population, especially for the cleft lip and cleft palate type. Other relevant findings were the considerable maternal exposure to alcohol, infections, smoking, and hypertension, as well as low supplementation with vitamins and minerals and deliberate consumption of analgesics, antibiotics, and antihypertensives during pregnancy. Characterization of the CL/P patient profile is essential for the planning of health services and integration among the health professionals involved in the diagnosis and treatment of these malformations. Our results reinforce the need for additional research to confirm the association between environmental factors and the development of orofacial clefts.

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Section: Discussionsupporting

confidence: 91%

Risk factors and comorbidities in Brazilian patients with orofacial clefts

et al. 2018

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“…Children with low birth-weight and with cleft lip and palate associated with other congenital malformations are more likely to be born with weight below normal 20,21 . Patients with orofacial clefts have additional risks of malnutrition and anaemia due to feeding problems 6 . Regarding mother's age, the majority were young, under the age of 29, a condition similar to that described in literature 13,22 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of cleft lip and palate in Brazilian children 2011 - 2015

Andrade¹,

Fernandes²,

Catão³

et al. 2018

Internet Journal of Medical Update - EJOURNAL

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Cleft lip and cleft palate are birth defects of complex etiology. The aim of this study was to evaluate the occurrence of cleft lip and palate in Brazilian children. An ecological and descriptive study, based on data from the Live Birth Information System (SINASC / DATASUS) between years 2011 and 2015 in the cities of João Pessoa, Campina Grande, Patos, Cajazeiras, and Sousa (State of Paraíba) was developed. Information on the presence of congenital anomalies and cleft lip and palate, gender of neonate, birth-weight (<2.5kg and ≥2.5kg) and mother's age were collected. Data were tabulated with Microsoft Excel software and presented through descriptive statistics (absolute and percentage distributions). In the study period, there were 206367 cases of live birth, with 1916 cases of children with congenital anomalies of which 109 (5.7%) had cleft lip and palate, predominantly males (66%). Regarding birth-weight, 27.5% had <2.5kg. The majority of mothers aged 20-29 years (45.9%). The city of Campina Grande concentrated the highest number of cases (50.5%), with prevalence of 7.36 cases per ten thousand live births. The frequency of cleft lip and palate was 5.2 per 10000 live births. Male children with normal birth-weight are the most affected by cleft lip and palate.

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“…A study of children with orofacial clefts in Burkina Faso found that up to 40% had anemia. 18 Moreover, there is evidence that in low-income settings, severe anemia may be associated with postoperative complications. 19 Fortunately, there were no in-hospital deaths in the present cohort, although Zhang and colleagues have noted that the clinical complications associated with cleft repair may precipitate grave and even fatal consequences in some cases.…”

Section: Discussionmentioning

confidence: 99%

Aboard the Smile Train: Outcomes of Primary Cleft Palate Repair at a Tertiary Care Center: À bord du Smile Train : les résultats cliniques de réparations de fentes palatines dans un centre de soins tertiaires

et al. 2020

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Introduction: Cleft palate repair is considered to be a safe procedure, yet still carries a 5% to 30% risk of complications. This study sought to assess the outcomes of this procedure in a high-burden Asian country that partners with the Smile Train to perform cleft surgeries. Methods: The Aga Khan University medical records database was queried for pediatric patients undergoing cleft surgery between 2014 and 2017. Data were abstracted from the patient medical records, and details of the clinical, demographic factors, and postoperative outcomes were assessed. Results: Among 142 patients with orofacial clefts, 102 (72%) underwent primary cleft palate repair, one-third (n = 36, 35%) of whom were operated as part of the Smile Train. The median preoperative hemoglobin was 11.4 g/dL (interquartile range: 10.7-12.0 g/dL), whereas the median weight was 8.3 kg (7.7-11.4 kg). Nearly two-thirds (n = 64, 63%) of the cohort underwent preoperative cardiology screening, with only a minority undergoing orthodontic treatment (n = 6, 6%). Approximately 15% (n = 15) of patients experienced a postoperative complication, most often a fistula (n = 11, 73%). On multivariable analysis, with each unit increase in hemoglobin levels, there was a 50% reduction in the odds of experiencing a complication (odds ratio: 0.51, 95% CI: 0.28-0.87). There were no in-patient deaths among the cohort. Conclusion: The results of the current study provide useful information to key stakeholders including patients, plastic surgeons, and policy makers on the outcomes of cleft palate repair in a developing country.

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Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso

Cited by 13 publications

References 31 publications

Risk factors and comorbidities in Brazilian patients with orofacial clefts

Risk factors and comorbidities in Brazilian patients with orofacial clefts

Prevalence of cleft lip and palate in Brazilian children 2011 - 2015

Aboard the Smile Train: Outcomes of Primary Cleft Palate Repair at a Tertiary Care Center: À bord du Smile Train : les résultats cliniques de réparations de fentes palatines dans un centre de soins tertiaires

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