Épidémiologie des malformations associées aux fentes labiales et palatines à propos d’une étude rétrospective de 324 cas

Bérail, A. De; Lauwers, F.; Noirrit‐Esclassan, Emmanuelle; Bassols, V. Woisard; Gardini, Beatrice; Galinier, P.

doi:10.1016/j.arcped.2015.05.005

Cited by 9 publications

(3 citation statements)

References 12 publications

(10 reference statements)

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“…The study found that females were the most affected (61.54%) with a sex ratio of 0.62. This result corroborates to the study of Berail A et al [13] in France in 2015. They study recorded 59, 1% of patients as female.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of Results of the Furlow’s Modified Technique in the Management of Cleft Palate in the Teaching Hospital of Conakry

Diallo¹,

Diallo²,

Conde³

et al. 2021

OJST

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Introduction: Cleft palate (CP) is a congenital dysmorphosis that results from a failure of the palatal processes of the maxillary buds and nasal septum to merge. The objectives of this study were to determine the frequency of complications of the modified Furlow technique and to evaluate its anatomical and functional outcomes. Materials and Method: This was a retrospective study that took place over a period of 4 years (from January 1 st , 2015 to December 31 th , 2018) in the Department of Odontostomatology and Maxillofacial Surgery at the National Hospital of Donka (Conakry, Guinea). Data retrieval consisted of records from patients operated on for cleft palate according to Furlow's modified technique only. The operative technique consisted of marginal incisions of the cleft according to the technique of the double Z-plasty of Furlow. Subsequently, the defect created between the 2 flaps and the anterior edge of the cleft was filled by two fat masses of Bichat sutured to each other with Vicryl 3-0. Four years after surgery, the patients were recalled for an evaluation of the anatomical and functional results. Results: 13 patients underwent surgical loading according to the modified Furlow technique. The average age of the patients was 6.9 years with an age range of 7 months and 17 years. Females were the most affected, with 61.54% of cases and a sex ratio of 0.62. The primary repair rate was 84.61% of cases. Immediate operative follow-up was simple with epithelialization of the flaps in all patients. Four (4) years after the surgeries, 12 patients were reevaluated (92.30%), among them one case (8.33%) of fistula complication was noted. The mobility of the veil and the phonation were good in 85.71% and 60% respectively. Articular disorders with nasonation were found in 2 patients (16.67%). Swallowing was normal in 85.72% of cases. Conclusion: The modified Furlow

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Section: Discussionsupporting

confidence: 93%

Evaluation of Results of the Furlow’s Modified Technique in the Management of Cleft Palate in the Teaching Hospital of Conakry

Diallo¹,

Diallo²,

Conde³

et al. 2021

OJST

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“…Two prior studies have identified that 39% 15 to 41% 20 of neonates with CL/P will present with at least one additional malformation 20 . However, different prevalence rates for multiple associated malformations in neonates with CL/P have been described in the literature, ranging from 25% 19 to 29.9% 21 . A systematic review concluded that cardiac malformation was eight times more frequent in apparently non-syndromic patients with CL/P when compared to the general population 22 , demonstrating a strong association between CL/P and other malformations.…”

Section: Discussionmentioning

confidence: 99%

Higher maternal age is associated with higher occurrence of cleft lip/palate in neonates under intensive care

et al. 2022

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Aim: To assess the prevalence of cleft lip and/or cleft palate (CL/P) and associated variables in neonates admitted to neonatal intensive care units (ICU). Methods: Medical charts for neonates born and admitted to the ICU between 2012 and 2018 were reviewed. Obstetric and neonatal variables were collected by a trained researcher. In the case group, all neonates with CL/P were included. The control group was formed by matching sex, prematurity and month of birth using random number generation. Neonates with congenital malformations were excluded from the control group. Adjusted logistic regression was used (p<0.05). Results: The prevalence of CL/P was 0.43% (n=15). Five cases were excluded, as pairing was not possible. Twenty neonates were included in the control group. In the final multivariate model, CL/P was only associated with increased maternal age. For each year of increase in maternal age, neonates had a 35.2% higher chance of presenting CL/P (95% confidence interval: 1.021–1.792). Conclusions: Higher maternal age was associated with higher occurrence of CL/P in neonates admitted to the ICU. No other neonatal or maternal independent variables were associated with CL/P. Due to missing data, interpretation of study results must be approached with caution.

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“…Orofacial clefts are among the most common congenital deformities, affecting approximately 1/700 births worldwide, with high ethnic and geographical variations [ 6 ]. South America tends to be one of the most-affected regions with more than 2 births out of 1000 being affected; among the least affected is Africa, with an average of 0.5/1000, and Western Europe, with an average of around 1.5/1000, and 1/1000 births in France [ 7 ]. Also, boys are more frequently affected, with a ratio of 2:1.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Granular Bone Substitute for Bone Regeneration Using an Optimized In Vivo Alveolar Cleft Model

Destrez,

Colin,

Testelin

et al. 2023

Bioengineering

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Alveolar cleft is a common congenital deformity that requires surgical intervention, notably using autologous bone grafts in young children. Bone substitutes, in combination with mesenchymal stem cells (MSCs), have shown promise in the repair of these defects. This study aimed to evaluate the regenerative capabilities of a granular bone substitute using an optimized alveolar cleft model. Thirty-six rats underwent a surgical procedure for the creation of a defect filled with a fragment of silicone. After 5 weeks, the silicone was removed and the biomaterial, with or without Wharton’s jelly MSCs, was put into the defect, except for the control group. The rats underwent μCT scans immediately and after 4 and 8 weeks. Analyses showed a statistically significant improvement in bone regeneration in the two treatment groups compared with control at weeks 4 and 8, both for bone volume (94.64% ± 10.71% and 91.33% ± 13.30%, vs. 76.09% ± 7.99%) and mineral density (96.13% ± 24.19% and 93.01% ± 27.04%, vs. 51.64% ± 16.51%), but without having fully healed. This study validates our optimized alveolar cleft model in rats, but further work is needed to allow for the use of this granular bone substitute in the treatment of bone defects.

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Épidémiologie des malformations associées aux fentes labiales et palatines à propos d’une étude rétrospective de 324 cas

Cited by 9 publications

References 12 publications

Evaluation of Results of the Furlow’s Modified Technique in the Management of Cleft Palate in the Teaching Hospital of Conakry

Evaluation of Results of the Furlow’s Modified Technique in the Management of Cleft Palate in the Teaching Hospital of Conakry

Higher maternal age is associated with higher occurrence of cleft lip/palate in neonates under intensive care

Evaluation of a Granular Bone Substitute for Bone Regeneration Using an Optimized In Vivo Alveolar Cleft Model

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