Epidemiological study on the relation of serum lactate dehydrogenase (LDH) isozymes and activity to protein intake in man.

Abstract

This paper reports the changes in the activity and isozyme pattern of serum LDH in healthy young men given a low protein diet (0.73-0.75/kg body weight; 40-50g/day) for 21 days. Serum total LDH activity showed no significant change in eight healthy young volunteers who received low protein diet for 21 days. However, the percentages of LDH-5 and LDH-4 increased significantly (P <0.01) from basal levels of 5.9•}2.3 and 7.1•}1.4 to 10.6•}2.9% and 10.1•}0.9%, respectively on day 14. These results suggest that measurements of the percentages of LDH-4 and LDH-5 isozymes can be used to evaluate the protein intake, but serum LDH activity cannot be used as an index of nutrition.

Relationship between serum lactate dehydrogenase and the pattern of food intakes in Japanese.

“…We observed that the percentage of LDH-4 and LDH-5 increased significantly in eight healthy young volunteers who low protein diets for 21 days (Imaki, et al 1984). We also observed that after 10 days of oral adminis-tration with 1 and 10 g/day of vitamin C six normal subjects, their percentage of LDH-4 and LDH-5 were lower than that before administration (Yoshimura, et al 1985).…”