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This paper reports the changes in the activity and isozyme pattern of serum LDH in healthy young men given a low protein diet (0.73-0.75/kg body weight; 40-50g/day) for 21 days. Serum total LDH activity showed no significant change in eight healthy young volunteers who received low protein diet for 21 days. However, the percentages of LDH-5 and LDH-4 increased significantly (P <0.01) from basal levels of 5.9•}2.3 and 7.1•}1.4 to 10.6•}2.9% and 10.1•}0.9%, respectively on day 14. These results suggest that measurements of the percentages of LDH-4 and LDH-5 isozymes can be used to evaluate the protein intake, but serum LDH activity cannot be used as an index of nutrition.

The effects of the food intake pattern on the activity and fraction pattern of serum ƒÁ-glutamyl transpeptidase (ƒÁ-GTP) were examined in 257 healthy Japanese men.

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