Epidemiological hazards of tobacco and its manifestations in oral health of a screened population in Northern India

Chaudhuri, Santanu; Dey, Somnath; Awasthi, Ashish

doi:10.1016/j.jcpo.2016.12.006

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…From various epidemiological studies, it has been shown that tobacco (smokeless or smokeable) is the main cause of oral cancer incidences worldwide [144–150]. Tobacco contains carcinogens, radioactive elements, and heavy‐metal ions capable of inducing cellular damage and genetic mutations in the oral mucosa [151–157].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, SSFA2 isoforms are potentially suitable for interactions with a diverse array of molecular partners (proteins, RNA, and/or DNA) and regulating multiple molecular pathways [142]. The TDSs of SSFA2 isoforms designed using RaptorX were validated From various epidemiological studies, it has been shown that tobacco (smokeless or smokeable) is the main cause of oral cancer incidences worldwide [144][145][146][147][148][149][150]. Tobacco contains carcinogens, radioactive elements, and heavy-metal ions capable of inducing cellular damage and genetic mutations in the oral mucosa [151][152][153][154][155][156][157].…”

Section: Notementioning

confidence: 99%

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In silico analyses of the human sperm‐specific antigen 2 and its role in oral squamous cell carcinoma

Khowal

Wajid

2022

Applied Research

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Oral cancer is a serious threat to humans worldwide. The frequently diagnosed form of oral cancer is oral squamous cell carcinoma (OSCC). The major etiologies of OSCC are the chemical constituents/carcinogens found in tobacco, areca nut, and alcohol. The sperm‐specific antigen 2 (SSFA2) is a crucial human gene and encodes for a protein that communicates between InsP3Rs and the cytoskeleton, regulating the cellular molecular pathways. This study analyzed the role of SSFA2 in OSCC using a computational approach. First, the evolutionarily conserved attributes of human SSFA2 canonical protein (HSCP) were scrutinized, followed by its comparison with human SSFA2 noncanonical proteins (HSNCPs); in addition, the transcript variants encoding for HSCP and HSNCP were also analyzed for sequence disparities. Molecular docking (iGEMDOCK) was performed for predicting HSCP residues interacting with OSCC carcinogens and OSCC therapeutants. Further, the protein interactome of HSCP was analyzed using Cytoscape. >70% amino acids (AAs) in HSCP were evolutionarily conserved; the AAs in the N‐terminal and C‐terminal regions were more conserved than that in the middle region of the protein. The 12 transcript and protein variants encoded by the human SSFA2 showed substantial differences in their sequences. Additionally, the human SSFA2 protein variants showed disparities in their secondary and tertiary structures. Molecular docking showed favorable interaction of carcinogens and therapeutants with the N‐terminus, middle region, and C‐terminus residues of HSCP, highlighting its strong candidature as the therapeutic target in oral malignancy. The structure and protein interactome analyses of HSCP predicted its diverse functionalities in the cell environment. Also, the sequence and structure heterogeneity present between HSCP and HSNCPs implies their varying functional attributes/roles in normal and/or diseased physiologies.

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Section: Discussionmentioning

confidence: 99%

Section: Notementioning

confidence: 99%

In silico analyses of the human sperm‐specific antigen 2 and its role in oral squamous cell carcinoma

Khowal

Wajid

2022

Applied Research

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“…El ardor y dolor referido por algunos pacientes, se atribuye al efecto inflamatorio que provoca la irritación crónica de la mucosa bucal por los traumas mecánicos que provocan los dientes rotos con bordes filosos y las prótesis mal ajustadas (Chaudhuri, Dey & Awasthi, 2017;Rodríguez, Santana, Fong, Rey, Jacas & Quevedo, 2014).…”

Section: Discussionunclassified

Evaluación clínica-epidemiológica de trastornos bucales potencialmente malignos en pobladores de Montalvo en Ambato.

Aguilar¹,

Castro²,

Barceló³

2019

dilemas

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Las neoplasias de cabeza y cuello representan el 17.6 % a nivel mundial. El cáncer de la cavidad bucal es uno de los más comunes que aparece en dicha región, siendo el 95 % carcinoma epidermoide con un pobre pronóstico de supervivencia, debido a que algunos se desarrollan a partir de trastornos potencialmente malignos peligrosamente asintomáticos, por lo que su detección precoz es imprescindible. El objetivo de la presente investigación es caracterizar los trastornos bucales potencialmente malignos mediante aspectos epidemiológicos, clínicos y topográficos, en pobladores atendidos en el subcentro de salud de Montalvo Ecuador.

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Does tobacco addiction relate to oral mucosal changes? An epidemiological study from North India

Chaudhuri¹,

Dey²,

Awasthi³

et al. 2017

J Public Health

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Epidemiological hazards of tobacco and its manifestations in oral health of a screened population in Northern India

Cited by 5 publications

References 19 publications

In silico analyses of the human sperm‐specific antigen 2 and its role in oral squamous cell carcinoma

In silico analyses of the human sperm‐specific antigen 2 and its role in oral squamous cell carcinoma

Evaluación clínica-epidemiológica de trastornos bucales potencialmente malignos en pobladores de Montalvo en Ambato.

Does tobacco addiction relate to oral mucosal changes? An epidemiological study from North India

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