Does tobacco addiction relate to oral mucosal changes? An epidemiological study from North India

Chaudhuri, Santanu; Dey, Somnath; Awasthi, Ashish; Bajpai, Ram

doi:10.1007/s10389-017-0787-2

Cited by 1 publication

(2 citation statements)

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“…Interestingly, many studies have reported that tobacco may be closely related to the lower incidence of RAS, but the mechanism is not yet clear. [4][5][6] The latest evidence shows that there is a certain relationship between change in the oral microbial flora and occurrence of recurrent oral ulcers. The decrease in several common oral bacteria, such as Streptococcus, Veillonella, Neisseria, and Gram-negative bacilli, has been linked to recurrent oral ulcers.…”

Section: Introductionmentioning

confidence: 99%

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Influence of cigarette smoking on oral microbiota in patients with recurrent aphthous stomatitis

Wang¹,

Na²,

Mi³

et al. 2022

Journal of Investigative Medicine

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Recurrent aphthous stomatitis (RAS) is a common recurrent ulcerative disease of the oral mucosa which is closely related to oral microbial composition. However, the specific effect and the mechanism of smoking in RAS are unclear. In this study, 16S rRNA sequencing technology was used to compare the differences in saliva microbial community between 28 non-smoking healthy controls (NSctrl), 31 non-smoking RAS patients (NSras), and 19 smoking RAS patients (Sras). The results showed that the bacterial community diversity in patients with RAS (NSras and Sras) was lower than that of NSctrl. The microbial community in smoking-associated RAS is less diverse and distinct from that of non-smokers. The RAS groups have higher abundance of Veillonella, Rothia, and Sneathia and lower abundance of Bacteroidales, Bacteroides, Wolinella, Moryella, Pyramidobacter, and Christensenellaceae at the genera level. A significantly different abundance of Anaerovorax, Candidatus Endomicrobium, Lactococcus, Sneathia, Veillonella, and Cloacibacterium was observed between the Sras and the NSras group. Notably, there was a significant difference in many species from the genus Prevotella and Treponema between the NSras and the Sras group. Further, the relative abundance of several taxa is correlated with smoking age or frequency, including Megasphaera, Haemophilus, Leptotrichia, and Rothia at the genera level, and Prevotella melaninogenica, Prevotella salivae, Megasphaera micronuciformis, Haemophilus parainfluenzae, Alloprevotella tannerae, Actinomyces naeslundii, Lautropia mirabilis, and Capnocytophaga sputigena at the species level. Among patients with RAS, smoking aggravated the pathways of respiration and human pathogens. Our results suggest that smoking is closely related to changes in the oral microbiota, which may contribute an opposite effect to the pathogenesis of RAS. This study provides new insight and theoretical basis for the cause and pathogenesis of RAS and better prevention and treatment.

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Section: Introductionmentioning

confidence: 99%

“…At present, there is no radical drug for treatment of RAS, and only a variety of drugs have been developed to promote its recovery. Interestingly, many studies have reported that tobacco may be closely related to the lower incidence of RAS, but the mechanism is not yet clear 4-6…”

Section: Introductionmentioning

confidence: 99%