Epidemiological, clinical and immunohistochemical aspects of canine lymphoma in the region of Porto Alegre, Brazil

Abstract

Pesq. Vet. Bras. 34(4):349-354, abril 2014 349 RESUMO.-[Aspectos epidemiológicos, clínicos e imuno-histoquímicos do linfoma canino na região de Porto Alegre.] Esse trabalho apresenta os achados epidemioló-gicos, clínicos e imuno-histoquímicos de linfomas caninos diagnosticados na região de Porto Alegre. Trinta cães foram incluídos no estudo; sendo principalmente machos (60%), sem raça definida (23%) e de meia-idade a idosos. A maioria (87%) dos cães afetados apresentou a forma anatômica multicêntrica. O imunofenótipo B foi detectado com mais frequência (62%); 37% dos cães apresentavam estadiamento clínico IV e 83% encontravam-se no subestádio "b". Linfadenopatia foi observada em 67% dos casos; outros sinais clínicos comumente detectados foram dispneia, prostração, diminuição do apetite e vômitos. Anemia foi a alteração laboratorial mais frequente (57%), seguida por leucocitose (40%), trombocitopenia (33%), linfopenia (30%), hiperglobulinemia (20%), hiperproteinemia (17%) e hipercalcemia (13%). Os resultados do presente estudo indicam que as características epidemiológicas e clínicas de cães com linfoma na região de Porto Alegre são semelhantes às observadas em todo o mundo.TERMOS DE INDEXAÇÃO: Linfoma, síndromes paraneoplásicas, sinais clínicos, imuno-histoquímica, caninos. INTRODUCTIONLymphoma is the most common canine hematopoietic neoplasm, with reported incidences of 24 to 33 cases per 100,000 dogs (Dorn et al. 1967, Teske 1994. In Brazil, lymphoma is the second most common canine neoplasm leading to death or euthanasia (Fighera et al. 2008 This paper describes the epidemiological, clinical and immunohistochemical characteristics of canine lymphomas diagnosed in the region of Porto Alegre, Brazil. Thirty dogs were enrolled in the study; most of them were male (60%), mixed-breed (23%) and middle-aged or older. The majority (87%) of affected dogs showed the multicentric form. The B-cell phenotype was most frequently detected (62%); 37% of the animals were in clinical stage IV, and 83% were classified as sub-stage "b". Lymphadenopathy was observed in 67% of the cases, and dyspnea, prostration, decreased appetite and vomiting were the most common clinical signs encountered. Anemia was a frequently encountered laboratory alteration (57%), as were leukocytosis (40%), thrombocytopenia (33%), lymphopenia (30%), hyperglobulinemia (20%) and hypercalcemia (13%). The results of this study indicate that the clinical features of dogs with lymphoma in the region of Porto Alegre are similar to those observed worldwide.

Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers

“…This usually occurs due to sequestration of lymphocytes because of lymph stasis. 37 Lymphocytosis has been observed in 20-22% of dogs with lymphoma, 35,38 but in animals with leukemic lymphoma the occurrence increases to 86%. 39 After the fourth cycle of chemotherapy, it was possible to verify the absence of clinical signs in all dogs according to anamnesis and clinical examination, although the animals showed an increase in lipid peroxidation levels and protein oxidation.…”

“…34 Other frequent alterations observed in the hematology of dogs with lymphoma included leukocytosis (40%) and lymphopenia (30%). 35 Leukocytosis is often detected in dogs with lymphoma, reflecting the inflammatory condition related to the tumor. 36 After chemotherapy, leukocytosis was not observed in treated animals, suggesting the reduction in Figure 2 Levels of advanced oxidation protein product (AOPP), TBARS, and FRAP of dogs with lymphoma (before and after chemotherapy) when compared to healthy dogs (control).…”

Epidemiological Data Concerning Canine Lymphoma over a Ten-Year Period (2005-2014), in Cluj-Napoca, Romania

“…Extranodal lymphoma is a rare form that can affect a number of tissues in the body. The most common locations of the extranodal lymphoma are the ocular and neural ones (Neuwald et al, 2014).…”

Köpek ve kedi lenfomalarının retrospektif değerlendirmesi (1985-2015)

“…Daha önce yapılan çalışmalarda (2,7,20,21) olduğu gibi bu çalışmada da % 63 oranla erkek köpeklerdeki lenfoma olgusu dişilere göre daha fazla görülmüştür.…”