Epidemiological and clinical features of erythema infectiosum in children in Novi Sad from 2000 to 2009

Prćić, Sonja; Gajinov, Zorica; Zrnić, Bogdan; Radulović, Anica; Matić, Milan; Djuran, Verica

doi:10.2298/vsp110607026p

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…The characteristic distribution of glove and socks can be seen with papular, petechial, pustular, and bullous morphologies (422)(423)(424)(425)(426)(427)(428), even desquamation (429); concurrently in family members (430); and with oral lesions (431), lymphangitis (432), and vasculitic features (see below). Lymphadenopathy is present in some children with fifth disease (433)(434)(435), and presentation with enlarged lymph nodes and hepatosplenomegaly can mimic mononucleosis (436,437).…”

Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Different patterns of skin manifestations associated with parvovirus B19 primary infection in adults

Mage

Lipsker

Barbarot

et al. 2014

Journal of the American Academy of Dermatology

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Erythema Infectiosum: A Narrative Review

Leung

Lam

Barankin³

et al. 2024

CPR

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Background: Erythema infectiosum occurs worldwide. School-aged children are most often affected. Since the diagnosis is mainly clinical, physicians should be well-versed in the clinical manifestations of erythema infectiosum to avoid misdiagnosis, unnecessary investigations, and mismanagement of the disease. Objective: The purpose of this article is to familiarize physicians with the wide spectrum of clinical manifestations and complications of erythema infectiosum associated with parvovirus B19 infection. Methods: A search was conducted in July 2022 in PubMed Clinical Queries using the key terms " Erythema infectiosum" OR “Fifth disease” OR “Slapped cheek disease”. The search strategy included all clinical trials, observational studies, and reviews published within the past 10 years. Only papers published in the English literature were included in this review. The information retrieved from the above search was used in the compilation of the present article. Results: Erythema infectiosum is a common exanthematous illness of childhood caused by parvovirus B19. Parvovirus B19 spreads mainly by respiratory tract secretions and, to a lesser extent, the saliva of infected individuals. Children between 4 and 10 years of age are most often affected. The incubation period is usually 4 to 14 days. Prodromal symptoms are usually mild and consist of low-grade fever, headache, malaise, and myalgia. The rash typically evolves in 3 stages. The initial stage is an erythematous rash on the cheeks, with a characteristic “slapped cheek” appearance. In the second stage, the rash spreads concurrently or quickly to the trunk, extremities, and buttocks as diffuse macular erythema. The rash tends to be more intense on extensor surfaces. The palms and soles are typically spared. Central clearing of the rash results in a characteristic lacy or reticulated appearance. The rash usually resolves spontaneously within three weeks without sequelae. The third stage is characterized by evanescence and recrudescence. In adults, the rash is less pronounced than that in children and is often atypical. Only approximately 20% of affected adults have an erythematous rash on the face. In adults, the rash is more frequently found on the legs, followed by the trunk, and arms. A reticulated or lacy erythema is noted in 80% of cases which helps to distinguish erythema infectiosum from other exanthems. Pruritus is noted in approximately 50% of cases. The diagnosis is mainly clinical. The many manifestations of parvovirus B19 infection can pose a diagnostic challenge even to the best diagnostician. Complications include arthritis, arthralgia, and transient aplastic crisis. In most cases, treatment is symptomatic and supportive. When parvovirus B19 infection occurs in pregnant women, hydrops fetalis becomes a real concern. Conclusion: Erythema infectiosum, the most common clinical manifestation of parvovirus B19 infection, is characterized by a “slapped cheek” appearance on the face and lacy exanthem on the trunk and extremities. Parvovirus B19 infection is associated with a wide spectrum of clinical manifestations. Physicians should be aware of potential complications and conditions associated with parvovirus B19 infection, especially in individuals who are immunocompromised, chronically anemic, or pregnant.

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Epidemiological and clinical features of erythema infectiosum in children in Novi Sad from 2000 to 2009

Cited by 3 publications

References 5 publications

Human Parvoviruses

Human Parvoviruses

Different patterns of skin manifestations associated with parvovirus B19 primary infection in adults

Erythema Infectiosum: A Narrative Review

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