Different patterns of skin manifestations associated with parvovirus B19 primary infection in adults

Mage, V.; Lipsker, Dan; Barbarot, S.; Bessis, Didier; Chosidow, Olivier; Giudice, P. Del; Aractingi, S.; Avouac, Jérôme; Bernier, C.; Descamps, V.; Dupin, Nicolas

doi:10.1016/j.jaad.2014.02.044

Cited by 50 publications

(40 citation statements)

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“…A few studies in adults have described symptoms and clinical characteristics of HPV-B19 infection [2, 4–10, 17]. Like these earlier studies, we found joint and cutaneous manifestations to be common and had a favourable outcome in most cases, with good response to NSAIDs [2, 4–10].…”

Section: Discussionsupporting

confidence: 80%

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Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults

et al. 2018

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BackgroundTo describe extra-haematological manifestations associated with human parvovirus B19 (HPV-B19) infection.MethodsWe conducted a nationwide multicentre study to retrospectively describe the characteristics and outcome of extra-haematological manifestations in French adults.ResultsData from 25 patients followed from 2001 to 2016 were analysed. Median age was 37.9 years (range: 22.7–83.4), with a female predominance (sex ratio: 4/1). Only 3 patients had an underlying predisposing condition (hemoglobinopathy or pregnancy). The most common manifestations were joint (80%) and skin (60%) involvement. Four patients (16%) had renal involvement (endocapillary proliferative or membranoproliferative glomerulonephritis, focal segmental glomerulosclerosis). Three patients (12%) had peripheral nervous system involvement (mononeuritis, mononeuritis multiplex, Guillain-Barré syndrome) and 2 (8%) presented muscle involvement. Other manifestations included hemophagocytic lymphohistiocytosis (n = 1), myopericarditis and pleural effusion (n = 1), and lymphadenopathy and splenomegaly mimicking lymphoma with spleen infarcts (n = 1). Immunological abnormalities were frequent (56.5%). At 6 months, all patients were alive, and 54.2% were in complete remission. In 2 patients, joint involvement evolved into rheumatoid arthritis. Six patients (24%) received intravenous immunoglobulin (IVIg), with a good response in the 3 patients with peripheral nervous system involvement.ConclusionsHPV-B19 infection should be considered in a wide range of clinical manifestations. Although the prognosis is good, IVIg therapy should be discussed in patients with peripheral nerve involvement. However, its efficacy should be further investigated in prospective studies.

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Section: Discussionsupporting

confidence: 80%

“…HPV-B19–related extra-haematological manifestations have been described, including glomerulonephritis, myositis, myocarditis, vasculitis and nervous system involvement, [11–17]. Furthermore, HPV-B19 infection can favour the development of auto-immune manifestations [18].…”

Section: Introductionmentioning

confidence: 99%

Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults

et al. 2018

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“…La infección por parvovirus B19 es frecuente siendo más común en edad escolar, en invierno y primavera, y su seroprevalencia llega hasta un 85% en adultos mayores 2 . Su diseminación es por vía respiratoria (gotitas) y su período de incubación dura entre 13 a 17 días 1 .…”

Section: Discussionunclassified

Vasculitis periflexual como manifestación de primoinfección por Parvovirus B19. A propósito de un caso

Curi-Tuma

Vial-Letelier

Wisse-Ayach³

et al. 2018

Rev. chil. dermatol

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ResumenLa infección por parvovirus B19 es común, siendo más recurrente en la edad escolar, invierno y primavera, y su seroprevalencia alcanza hasta el 85% en adultos mayores. La presentación típica de la infección por este virus se conoce como eritema infeccioso (o "quinta enfermedad", destacando la afectación facial característica y la erupción reticulada), sin embargo, se han reportado múltiples manifestaciones dermatológicas de la infección por el virus.Paciente de 17 años, con antecedente de migraña, que desarrolló máculas y pápulas eritematoso-violáceas confluentes con petequias, predominando en pliegues antecubital, poplíteo e inguinal y cara lateral del tórax, con menor compromiso abdominal, espalda y muslos. La biopsia de la piel y los exámenes de laboratorio fueron compatibles con vasculitis leucocitoclástica secundaria a infección por parvovirus B19.Se han descrito diferentes patrones de la manifestación cutá-nea de la infección por parvovirus B19. La paciente del caso clínico expuesto desarrolló un rash cutáneo que constituyó una superposición entre el patrón vasculítico y el periflexural, presentación poco descrita en la literatura.Palabras claves: Parvovirus B19; primoinfección; vasculitis leucocitoclástica; vasculitis periflexural summaRy Parvovirus B19 infection is common, being more typical among school-age children, with seasonal changes. Infectious erythema (or 'fifth disease') is the classic manifestation of this viral infection; however, multiple dermatological manifestations of the virus infection have been reported. An otherwise healthy 17-year-old female patient, developed confluent erythematous-violaceous macules and papules with petechiae. They mainly involved the antecubital, popliteal and inguinal crease and lateral thorax. The lower abdomen, back and thighs were less involved. The skin biopsy and laboratory workup showed leukocytoclastic vasculitis and positive reaction for parvovirus B19, respectively.A variety of patterns have been described related to the cutaneous manifestation of parvovirus B19 infection. In the present case, the patient developed a cutaneous rash that constituted an overlap between the vasculitic and the periflexural patterns. This variant of parvovirus B19 infection has not been frequently described in literature. La infección por parvovirus B19 puede ser asintomática, presentarse en forma sindromática con una evolución benigna o también con manifestaciones severas pudiendo comprometer incluso la vida del paciente. El compromiso cutáneo es frecuente y la presentación típica de la infección por este virus se conoce como eritema infeccioso. Sin embargo, se han reportado distintos patrones de compromiso dermatológico de la infección por el virus. Caso ClíniCoPaciente de sexo femenino, de 17 años, con antecedentes de migraña. Consultó por cuadro de 4 días de evolución de lesiones eritematosas pruriginosas progresivas, inicialmente en fosa antecubital derecha a lo que se agregaron posteriormente lesiones similares en abdomen y muslos. No refirió fiebre ni compromiso...

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“…Coxsackie virus-A6 is increasingly recognized to cause HFMD with atypical presentations in children [2][3][4][5][6][22][23][24]. In addition to hand, foot and buttock involvement, rash may be present periorally, truncally or with a predilection for areas of active atopic dermatitis, termed 'eczema coxsackium'.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to hand, foot and buttock involvement, rash may be present periorally, truncally or with a predilection for areas of active atopic dermatitis, termed 'eczema coxsackium'. Desquamation occurs in approximately 50% of cases, and rarely, a more severe form of infection occurs in the absence of rash [2][3][4][5][6]9,17,[22][23][24]. Desquamation occurs in approximately 50% of cases, and rarely, a more severe form of infection occurs in the absence of rash [2][3][4][5][6]9,17,[22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Viral exanthems

Keighley

Saunderson

Kok

et al. 2015

Current Opinion in Infectious Diseases

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Different patterns of skin manifestations associated with parvovirus B19 primary infection in adults

Cited by 50 publications

References 15 publications

Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults

Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults

Vasculitis periflexual como manifestación de primoinfección por Parvovirus B19. A propósito de un caso

Viral exanthems

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