Epidemiologic Study of Primary Brain Tumors in Miyazaki Prefecture: A Regional 10-year Survey in Southern Japan

Abstract

The increased use of neuroimaging and the aging of society have changed the incidence and proportion of histological types of intracranial tumors in Japan. A population-based epidemiological survey has been reported only from Kumamoto Prefecture. We performed a 10-year survey in Miyazaki Prefecture to compare our findings with the incidence rate (IR) of primary intracranial tumors (PIT) reported in the Kumamoto survey. Our study included 1915 new cases of PIT diagnosed in Miyazaki Prefecture between 2007 and 2016. The crude IR was 16.97/100000/year. The most common tumor was meningioma (46.3%), followed by glioma (17.1%), pituitary adenoma (13.1%), schwannoma (8.2%), and malignant lymphoma (3.8%). The age-specific IR of all PITs and of meningiomas, gliomas, pituitary adenomas, schwannomas, lymphomas, and germ cell tumors was similar in both prefectures. To directly compare with the age-adjusted IRs reported in the Kumamoto survey, we calculated the IR for the two prefectures. The age-adjusted IR of primary brain tumors in Miyazaki Prefecture was 14.65/100000/year, which was slightly higher than in the Kumamoto survey (14.09/100000/year between 1989 and 2008). The ageadjusted IR of glioma, schwannoma, and malignant lymphoma showed only a small difference between Miyazaki and Kumamoto. However, the age-adjusted IR of meningiomas was higher in Miyazaki than Kumamoto (6.15-vs. 4.97/100000/year), but the IR of pituitary adenoma was higher in Kumamoto than Miyazaki (2.66-vs. 2.13/100000/year). Although there were some differences between the two surveys, the IR of PIT showed a similar pattern in Kumamoto and Miyazaki, which are neighboring districts on Kyushu Island.

Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asian populations

“…In contrast, the ASR of high-grade gliomas in China was 1-4 28 . The overall glioma ASRs were 2.76 and 2.89 in Kumamoto and Miyazaki prefectures respectively 29,30 . The Korean population also showed a similar ASR of 2.82 31 .…”

“…An ASR of 0.85 was reported in Taiwan, a province of China 19 . In Japan, the ASR was 1.26 in Miyazaki prefecture 30 . Four Korean studies reported ASR values of 0.59, 0.77, 0.87, and 1.11 ( Figure 2A ) 18 , 31 , 41 , 42 .…”

Coexisting lipomatous meningioma and glioblastoma in Cowden syndrome: A unique tumor association

“…Such a broad‐ranging frequency might be related to both the small size of the series and to the different inclusion criteria. These figures in CS are notably higher than the global incidence rate of 7.9/100 000/year reported in recent epidemiological studies 27,28 . The fact that eight out of the 19 CS patients had multiple meningiomas (Table 1) reinforces such a predisposition in this syndrome.…”

“…These figures in CS are notably higher than the global incidence rate of 7.9/100 000/year reported in recent epidemiological studies. 27,28 The fact that eight out of the 19 CS patients had multiple meningiomas (Table 1) reinforces such a predisposition in this syndrome. Our report and literature review support previous claims about the inclusion of meningiomas within the CS consensus diagnostic criteria.…”

Optimization and efficiency analysis of deep learning based brain tumor detection

“…These can also be divided into primary tumors, which originate inside the brain, and secondary tumors, which typically spread from cancers outside the brain and are referred to as brain metastasis tumors. As per [9] in the world, Glioma, meningioma, and pituitary tumors are common primary tumors with occurrence percentage as shown in Fig. 1.…”