Epidemiologic risks for food allergy

Lack, Gideon

doi:10.1016/j.jaci.2008.04.032

Cited by 551 publications

(436 citation statements)

References 52 publications

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“…Recent hypotheses about the development of food sensitization suggest that exposure via the skin may lead to allergic sensitization, and some investigators suggest that eczema may play an important role in the development of food sensitiza- tion. 27,28 Our findings offer support of this hypothesis but prospective studies are needed.…”

Section: Discussionsupporting

confidence: 66%

The associations of triclosan and paraben exposure with allergen sensitization and wheeze in children

Spanier

Fausnight²,

Camacho³

et al. 2014

allergy asthma proc

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Section: Discussionsupporting

confidence: 66%

The associations of triclosan and paraben exposure with allergen sensitization and wheeze in children

Spanier

Fausnight²,

Camacho³

et al. 2014

allergy asthma proc

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“…Gideon Lack has proposed the dual exposure hypothesis: exclusion of foreign proteins from the infant’s diet means that one is primarily exposed via other routes, i.e. the cutaneous or inhalant route, which may result in sensitization and allergy development, rather than tolerance [42,43]. Dietary proteins normally induce antigen-specific active immune tolerance, termed oral tolerance, as observed in experimental animals [44,45] as well as in humans [46].…”

Section: Discussionmentioning

confidence: 99%

Late introduction of fish and eggs is associated with increased risk of allergy development – results from the FARMFLORA birth cohort

Jönsson

Barman

Brekke

et al. 2017

Food & Nutrition Research

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The prevalence of allergy is markedly low in children growing up on farms. An increasing number of studies indicate that the timing of food introduction may affect allergy development. We aimed to investigate if protection against allergy in farm environments may be mediated through differences in food-introduction practices between farm and non-farm families, using an explorative approach. Twenty-eight farm and 37 non-farm children were included in the FARMFLORA birth cohort. Practices of breastfeeding and introduction of formulas and complementary foods were collected by questionnaires at 6, 12, and 18 months of age. Allergy was diagnosed by pediatricians at 3 years of age. The only difference in food-introduction practices observed between farm and non-farm children was an earlier introduction of nuts in farmers (median month: 11 [IQR: 8–6] in farmers, 15 [12–19] in non-farmers). One farm child (4%) and 10 non-farm children (27%) were allergic at 3 years of age. Lower risk of allergy development was associated with early exclusive breastfeeding (continuous variable; OR = 0.59, 95% CI: 0.39–0.89), but also having received eggs (OR = 0.08, 95% CI: 0.13–0.54) and fish (logistic regression not applicable, P = 0.01 in likelihood ratio testing [χ2]) at 10 months of age or earlier compared to later. Our results were not affected by reverse causation, as judged by a questionnaire sent to the families in retrospect. Timing of introduction of complementary foods is unlikely to contribute to the lower risk of allergy among farm children. Although early exclusive breastfeeding was associated with a lower rate of allergy development, postponed introduction of complementary foods might increase the risk of developing allergy. Owing to the limited sample size, our results are only indicative, but support prior findings.

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“…Food allergy is an important and rising clinical problem [1][2][3]. The pathogenesis of allergic diseases is not yet clear.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Kamer

Kulig²,

Lewkowicz³

et al. 2010

Folia Histochem Cytobiol.

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Abstract:The authors evaluated mRNA TLR4 expression on neutrophils and the chosen parameters of oxidative-antioxidative balance in blood of 35 children with food allergy (17 of them with IgE-dependent allergy and 18 with IgE-independent allergy) and 15 healthy children without any allergy. The age of these children ranged from 1 to 36 months. Children with food allergy in comparison with healthy children were found to have lower mRNA TLR4 expression, higher average value of chemiluminescence (CL) and its increase after stimulation by fMLP, PMA and OZ as well as lower TAS values. Disturbances of oxidative-antioxidative balance were found in children with food allergy. We suggest that natural immunity is involved in the development of food allergy mechanisms. Moreover, chemiluminescence can be used as an additional diagnostic test.

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Epidemiologic risks for food allergy

Cited by 551 publications

References 52 publications

The associations of triclosan and paraben exposure with allergen sensitization and wheeze in children

The associations of triclosan and paraben exposure with allergen sensitization and wheeze in children

Late introduction of fish and eggs is associated with increased risk of allergy development – results from the FARMFLORA birth cohort

Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

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