Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy.

Abstract

Abstract:The authors evaluated mRNA TLR4 expression on neutrophils and the chosen parameters of oxidative-antioxidative balance in blood of 35 children with food allergy (17 of them with IgE-dependent allergy and 18 with IgE-independent allergy) and 15 healthy children without any allergy. The age of these children ranged from 1 to 36 months. Children with food allergy in comparison with healthy children were found to have lower mRNA TLR4 expression, higher average value of chemiluminescence (CL) and its increase after stimulation by fMLP, PMA and OZ as well as lower TAS values. Disturbances of oxidative-antioxidative balance were found in children with food allergy. We suggest that natural immunity is involved in the development of food allergy mechanisms. Moreover, chemiluminescence can be used as an additional diagnostic test.

Selected serum oxidative stress biomarkers in dogs with non‐food‐induced and food‐induced atopic dermatitis

“…In the present study, OS was supported by both a significant decrease of antioxidant capacity, except for FRAP values, and increase of oxidative damage in the serum of both NFIAD and FIAD dogs compared to healthy dogs. The OS observed in this study is in accordance with previous reports in canine and human AD, and also in human food allergy . However, in previous studies performed on canine AD, neither distinction between FIAD and NFIAD, nor pruritus was reported, and the biomarkers measured were different compared to this study .…”