Epidemic Methicillin-Susceptible Staphylococcus aureus Lineages Are the Main Cause of Infections at an Iranian University Hospital

Abstract

The majority of Staphylococcus aureus infections from Isfahan, Iran, were caused by epidemic methicillinsusceptible S. aureus (MSSA) lineages, sequence type 8 (ST8), ST22, ST30, and ST6. The predominant methicillin-resistant S. aureus strain was ST239. We observed a high prevalence of Panton-Valentine leukocidin-positive MSSA strains (19.7%), which is a matter of considerable concern, since these strains have the ability to cause severe infections.

StaphylococcalCassette Chromosomemec(SCCmec) Typing of Methicillin-ResistantStaphylococcus aureusStrains Isolated from Community- and Hospital-Acquired Infections

“…The present study showed that the prevalence of resistant strains to methicillin has steadily increased in comparison with a previous study performed in the same hospital (20% vs. 54%) (5,26). Furthermore, a similar prevalence rate (54%) was reported by Moghadami Based on SCCmec typing, MRSA strains are classified into 5 different allotypes, 2 of which have been identified in Asian countries.…”

Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus

“…ST239 is (or has been) the most abundant ST recovered from hospital infections in Asia (except Japan) and eastern Australia (Aires de Sousa et al, 2003; Kim et al, 2011; Ko et al, 2005; Liu et al, 2009; Nimmo et al, 2008; Soo Ko et al, 2005; Xu et al, 2009). In addition, many MRSA isolates recovered from hospital patients in South America, Eastern Europe, and the Middle East belong to ST239 (Brazilian, Portuguese, Hungarian, and Viennese clones) (Alp et al, 2009; Amorim et al, 2002; Bartels et al, 2008; Grundmann et al, 2010; Havaei et al, 2011; Mayor et al, 2007; Melter et al, 2003; Vivoni et al, 2006; Wisplinghoff et al, 2005). Given the high population in the countries where it predominates, ST239 may represent the most successful MRSA lineage worldwide.…”

Community-Associated Methicillin-Resistant Staphylococcus aureus Case Studies

“…Most other major clonal complexes such as ST5-IV, ST6-IV, ST8-IV, ST22-IV, and ST97 have been reported at lower frequencies. These clonal complexes are also well represented among MSSA isolates and are a significant cause of S. aureus infections, including in the nosocomial setting such as ST8-MSSA in an Iranian hospital [115]. …”