Epicatechin inhibits radiation-induced auditory cell death by suppression of reactive oxygen species generation

Dexamethasone Protects Against Radiation-induced Loss of Auditory Hair Cells In Vitro

“…Similar to our findings with DXM treatment, the treatment of OC and/or cochlear cell lines exposed to 20 Gy of radiation with either a p38 MAPK inhibitor (SB203580), a JNK inhibitor (SP600125), or antioxidants (e.g., L-acetylcysteine and epicatenin) produced a significant improvement in cell viability after a radiation injury (7,9,10). Otoprotection against 20 Gy of radiation was also demonstrated and confirmed after treatment with epicatenin and a p38 MAPK inhibitor in a zebrafish embryo animal model (9,10).…”

Radiation-induced Cochlea Hair Cell Death: Mechanisms and Protection

“…J. H. Pyun et al (2011) also demonstrated the inhibition of radiation-induced apoptosis in cochlea hair cells by EC. After treating with EC combined with radiation, significant increase of cell viability, decrease of apoptosis, inhibition of ROS generation and reduction of signals related to apoptosis were observed in hair cell lines HEI-OC1 and UB-OC1.…”

“…This leads us to think that JNK may also play an important role in irradiated hair cells. J. H. Pyun et al (Pyun et al, 2011) found that the expression of p-JNK was significantly up-regulated in hair cell line HEI-OC1 within 24h post-radiation, which led to the activation of c-Jun. Another research directed by Wong-Kein Low (Low et al, 2006b) analyzed the expression of c-Jun but not the JNK in hair cell line OC-k3 after irradiation.…”

Late-responding normal tissue cells benefit from high-precision radiotherapy with prolonged fraction delivery times via enhanced autophagy

“…Radiation-induced ROS in HEI-OC1 cells has been reported to play a key role in the promotion of apoptosis by affecting mitochondrial permeability, release of cytochrome c, and activation of p53 and caspases19. Suppression of ROS accumulation, which could protect cells from radiation-induced cytotoxicity, inhibited radiation-induced apoptosis in HEI-OC1 cells20. Here, we found that the reduction of the apoptotic cells after irradiation with prolonged FDT was stronger in late-responding normal tissue cells (Fig.…”