Dexamethasone Protects Against Radiation-induced Loss of Auditory Hair Cells In Vitro

Dinh, Christine T.; Chen, Si; Padgett, Kyle R.; Dinh, John; Telischi, Fred; Elsayyad, Nagy; Johnson, Perry B.; Angeli, Simón I.; Bas, Esperanza; Goncalves, Stefania; Eshraghi, Adrien A.; Water, Thomas Van De

doi:10.1097/mao.0000000000000850

Cited by 4 publications

(2 citation statements)

References 24 publications

(28 reference statements)

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“…In addition, aminothiol prc-210 alleviated inflammation and spinal ganglion injury in guinea pigs and consequently promoted better ABR responses in comparison with the control group [51]. Similarly, the synthetic steroid dexamethasone protected organ of Corti rat explants from irradiation as it reduced the levels of oxidative stress and apoptosis in a dose-dependent manner [52].…”

Section: Sensorineural Hearing Lossmentioning

confidence: 96%

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

Azzam¹,

Mroueh²,

Francis³

et al. 2020

ecancer

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Head and neck cancer (HNC) is the sixth most common human malignancy with a global incidence of 650,000 cases per year. Radiotherapy (RT) is commonly used as an effective therapy to treat tumours as a definitive or adjuvant treatment. Despite the substantial advances in RT contouring and dosage delivery, patients suffer from various radiation-induced complications, among which are toxicities to the nervous tissues in the head and neck area. Radiation-mediated neuropathies manifest as a result of increased oxidative stress-mediated apoptosis, neuroinflammation and altered cellular function in the nervous tissues. Eventually, molecular damage results in the formation of fibrotic tissues leading to susceptible loss of function of numerous neuronal substructures. Neuropathic sequelae following irradiation in the head and neck area include sensorineural hearing loss, alterations in taste and smell functions along with brachial plexopathy, and cranial nerves palsies. Numerous management options are available to relieve radiation-associated neurotoxicities notwithstanding treatment alternatives that remain restricted with limited benefits. In the scope of this review, we discuss the use of variable management and therapeutic modalities to palliate common radiation-induced neuropathies in head and neck cancers.

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Section: Sensorineural Hearing Lossmentioning

confidence: 96%

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

Azzam¹,

Mroueh²,

Francis³

et al. 2020

ecancer

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show abstract

“…In the literature, there are a few studies investigating the potential benefit of different chemical agents against radiation-induced inner ear damage. In an experimental study, Dinh et al (2015) reported that dexamethasone may potentially be a therapeutic option for preventing radiation-induced hearing loss. Karaer et al (2015) investigated the effects of N-acetyl-5-methoxytryptamine (melatonin) on radiation-induced inner ear damage and concluded that melatonin may have significant beneficial effects on cochlear damage secondary to ionizing radiation.…”

Section: Color Version Available Onlinementioning

confidence: 99%

Tetramethylpyrazine Attenuates Radiation-Induced Ototoxicity in a Rat Model

et al. 2023

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Introduction: Tetramethylpyrazine (TMP) is a chemical compound, which has been shown to possess numerous biological features such as anticoagulation, inhibition of platelet aggregation, anti-inflammation, capillary dilatation, improvement in microcirculation, and protection against reactive oxygen radicals. The aim of the present study was to investigate the protective effect of TMP against radiation-induced ototoxicity. Materials and Methods: 40 rats were divided into four groups. The first group was irradiated for 5 days. The second group received a single dose of 140 mg/kg/day intraperitoneal TMP given to the rats 30 min before radiotherapy (RT) for 5 days. The third group received a single dose of 140 mg/kg/day i.p. TMP for 5 days, whereas the fourth group was administered saline. All rats underwent distortion product otoacoustic emission (DPOAE) and auditory brainstem response measurements before and after the application. The temporal bulla of animals was removed for immunohistopathological examination. Results: Signal-noise ratio values were significantly decreased in the RT group for the frequencies of 2–32 kHz after RT (p < 0.05), whereas the difference was not significant in terms of pre- and posttreatment values for the other groups. Also in the RT group, the ABR thresholds were significantly increased after treatment. In H&E staining, the mean scores for outer hair cells (OHCs), stria vascularis (SV), and spiral ganglion (SG) injuries were significantly higher in RT and RT + TMP groups than in the other groups. The mean OHCs and SV injury scores were also significantly higher in the RT group than in the RT + TMP group (p < 0.05). The number of cochleas that showed cytoplasmic caspase-3 immunoreactivity in the OHC, SV, and SG was significantly higher in RT and RT + TMP groups than in the other groups. Conclusion: The findings of the present study suggest that TMP may have a therapeutic potential for preventing sensorineural hearing loss (SNHL) related to RT.

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Combined antioxidants and anti-inflammatory therapies fail to attenuate the early and late phases of cyclodextrin-induced cochlear damage and hearing loss

et al. 2022

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Dexamethasone Protects Against Radiation-induced Loss of Auditory Hair Cells In Vitro

Cited by 4 publications

References 24 publications

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

Tetramethylpyrazine Attenuates Radiation-Induced Ototoxicity in a Rat Model

Combined antioxidants and anti-inflammatory therapies fail to attenuate the early and late phases of cyclodextrin-induced cochlear damage and hearing loss

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