Radiation-induced Cochlea Hair Cell Death: Mechanisms and Protection

Dexamethasone Protects Against Radiation-induced Loss of Auditory Hair Cells In Vitro

“…Although the clinical implications may be huge in understanding radiation-induced HL and identifying potential targetspecific agents to protect against radiation ototoxicity, published studies are still preliminary, and more research in this field is needed before treatment in clinical trials can begin (27).…”

“…Although OC-and cochlear-derived cell lines are genetically modified to express some features inherent in inner ear tissue, these cell lines can replicate, which is not a feature of postmitotic auditory HCs that have little potential to regenerate. Unlike in rat OC explants, it is difficult to extrapolate the differential effects of radiation on the basal, middle, and apical turns using OC-and cochlear-derived cell lines and even zebrafish models (27).…”

Does Short Term Usage of Fresh Pomegranate Juice (FPJ) Protect Cochlear Hair Cells after Cisplatin-Based Chemo-Irradiation?

“…On the other hand, the methodology of our study is more comprehensive, because we investigated the protective effects of FPJ on ototoxicity originating from cisplatin, irradiation, and combined use of cisplatin and irradiation. As it is known, radiotherapy is widely used for the treatment of neck cancers, and cochlear hair cell death is regarded to be responsible for radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers [18] .…”

Methylprednisolone use during radiotherapy extenuates hearing loss in patients with nasopharyngeal carcinoma

“…The inner ear inevitably received a certain amount of irradiation . There is a high incidence of hearing impairment after radiotherapy; 1 year after radiotherapy, the reported incidence of sensorineural hearing loss is 50% . Patients often have tinnitus, dizziness, and other symptoms.…”