Epicardial adipose tissue: a review of physiology, pathophysiology, and clinical applications

Şengül, Cihan; Özveren, Olcay

doi:10.5152/akd.2013.075

Cited by 47 publications

(68 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, the mean value of two images obtained in the parasternal long-axis and short-axis views should be calculated. Additionally, it would be better to give inter- and intraobserver variability for epicardial adipose tissue measurement in the current study [12]. …”

mentioning

confidence: 99%

Epicardial Fat Thickness in Psoriasis Patients

Balta¹,

Balta²,

Öztürk³

et al. 2014

Dermatology

View full text Add to dashboard Cite

mentioning

confidence: 99%

Epicardial Fat Thickness in Psoriasis Patients

Balta¹,

Balta²,

Öztürk³

et al. 2014

Dermatology

View full text Add to dashboard Cite

“…; P = 0.008) were higher in the CAD group than in the normal subjects. SAT area was higher in the normal group (176.48 ± 79.56 versus 147.56 ± 56.63 cm 2 ; P = 0.005).…”

Section: Resultsmentioning

confidence: 84%

“…Perivascular EAT surrounding coronary vessels promotes the development of atherogenesis by direct diffusion of various cytokines and free fatty acid (FFA) into the vessel wall and the systemic circulation. 1,2) In contrast, intramyocardial coronary artery segments not in direct contact with EAT rarely contain atherosclerotic plaque. 35) Another possible explanation for the relationship between EAT and CAD is the enhanced infl ammatory responses in EAT.…”

Section: Discussionmentioning

confidence: 99%

The Associations of Epicardial Adipose Tissue With Coronary Artery Disease and Coronary Atherosclerosis

et al. 2014

View full text Add to dashboard Cite

SummaryEpicardial adipose tissue (EAT) is presumed to play an important role in the development of coronary artery disease (CAD). The purpose of our study was to examine the infl uence of EAT volume measured by cardiac CT on the severity and presence of CAD. A total of 209 subjects (114 normal subjects and 95 patients with CAD) underwent cardiac and abdominal computed tomography (CT) scan before diagnostic coronary angiography. Pixels with a threshold range of -190 to -30 Hounsfi eld units were identifi ed as EAT. CAGE ≥ 20, CAGE ≥ 50, and modifi ed Gensini index were used to define the extent and severity of CAD. While there was no significant difference in BMI and WC between the two groups, the mean EAT volume was higher in the CAD group than in the normal subjects (102.4 ± 41.87 cm 3 versus 125.36 ± 47.64 cm 3 , P < 0.001). EAT was signifi cantly associated with CAGE ≥ 20, CAGE ≥ 50, and Gensini score by linear regression analyses after adjusting for age, gender, smoking, and alcohol use. The severity of CAD increased linearly with each tertile increase in EAT volume (P for trend < 0.05). Similarly, the coronary artery calcium (CAC) score was also increased with each increase in EAT tertile (P = 0.002). In multivariate logistic regression models, EAT and VAT were signifi cantly associated with the presence of CAD and CAC in age, gender, smoking, alcohol use, and BMI adjusted models. In conclusion, EAT volume measured by CT is associated with the presence and severity of CAD. EAT may give important information for risk evaluation in CAD. (Int Heart J 2014; 55: 197-203)

show abstract

“…In our study, we found that CACS was significantly correlated with total coronary plaque area (p=0.000 rho=0.997) but not with EFV (p=0.085, rho=0.168). It is known that body mass index affects EFV [22]. Subgroup analysis was carried out for non-obese patients to remove the effect of obesity on EFV (n=72).…”

Section: Discussionmentioning

confidence: 99%

Impaired Aortic Elasticity and Diastolic Functions Are Associated with Findings of Coronary Computed Tomographic Angiography

et al. 2014

View full text Add to dashboard Cite

BackgroundCoronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Aortic elasticity and diastolic functions are helpful parameters in assessment of CAD. In this study we aimed to learn whether diastolic function and aortic elastic properties measured by echocardiography are associated with coronary calcium score (CACS), epicardial fat volume (EFV), and plaque area measured by coronary tomographic angiography.Material/MethodsWe enrolled 106 consecutive patients suspected of CAD undergoing coronary CTA and transthoracic echocardiography in this prospective study. Total CACS, plaque area, and EFV were calculated via CTA. Aortic stiffness index (ASI) and aortic distensibility (AD) were measured via echocardiography.ResultsThe patients with diastolic dysfunctions of any degree had significantly higher ASI, higher CACS, higher plaque area, and EFV. We found that as the ASI increases, the CACS and total coronary plaque area both increase, showing that there is a strong positive correlation between ASI, CACS, and total coronary plaque area. There was a significant correlation between ASI and EFV, but with a lower statistical value.ConclusionsAortic elasticity was correlated with CACS and plaque area. Diastolic dysfunction was observed more commonly among patients with higher CACS and EFV. Epicardial fat volume was not as strong as CACS in reflecting aortic elasticity.

show abstract

Epicardial adipose tissue: a review of physiology, pathophysiology, and clinical applications

Cited by 47 publications

References 47 publications

Epicardial Fat Thickness in Psoriasis Patients

Epicardial Fat Thickness in Psoriasis Patients

The Associations of Epicardial Adipose Tissue With Coronary Artery Disease and Coronary Atherosclerosis

Impaired Aortic Elasticity and Diastolic Functions Are Associated with Findings of Coronary Computed Tomographic Angiography

Contact Info

Product

Resources

About