Epicardial Fat Thickness in Psoriasis Patients

Balta, İlknur; Balta, Şevket; Öztürk, Cengiz; Demırkol, Sait; Demır, Mustafa

doi:10.1159/000357403

Cited by 8 publications

(6 citation statements)

References 13 publications

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“…Despite the fact that increased EAT cannot be considered as a CV risk factor, some reports suggest that it could be an epiphenomenon in follow up of the progression of atherosclerosis . Besides, EAT increases in inflammatory conditions such as psoriasis, which suggests the association between EAT and inflammation . Therefore, results of the present study reporting increased EAT thickness in HD patients compared to healthy individuals confirm the results of previous studies.…”

Section: Discussionsupporting

confidence: 89%

Relationship Between Epicardial Adipose Tissue, Inflammation and Volume Markers in Hemodialysis and Transplant Patients

et al. 2015

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Cardiovascular (CV) diseases are still the most important cause of morbidity and mortality in both patients receiving hemodialysis (HD) treatment and individuals with renal transplantation (Rtx). Measurement of epicardial adipose tissue (EAT) thickness is an easily applied, cheap, and useful recent method predicting increased CV risk. We aimed to compare EAT changes in HD and Rtx patients and the association between EAT and inflammatory and CV volume markers in both groups. A total of 124 patients: 45 Rtx, 43 HD patients and 36 healthy controls were enrolled in the study. Laboratory parameters and inflammatory markers (interleukin-6 [IL-6] and high sensitive C-reactive protein [Hs-CRP]) were evaluated from venous blood samples after an overnight fast. EAT thickness was measured with transthoracic echocardiography. The levels of Hs-CRP, IL-6, systolic and diastolic blood pressures, left atrial (LA) diameter, left atrial index (LAI), left ventricular mass (LVM) and LVM index (LVMI) were significantly higher in the HD patients than in the other groups. EAT was positively correlated with age, body mass index (BMI), time on dialysis, serum creatinine, total cholesterol, Low density lipoprotein-cholesterol, and LVM in Rtx group and positively correlated with age, BMI, duration of dialysis, Hs-CRP, IL-6, LAI and LVMI and inversely correlated with inferior vena cava collapse index (IVC-CI) in HD group. EAT thickness of RTx patients (whose previous HD duration was similar to those in HD group) are similar to the healthy population and significantly thinner than patients on HD.

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Section: Discussionsupporting

confidence: 89%

Relationship Between Epicardial Adipose Tissue, Inflammation and Volume Markers in Hemodialysis and Transplant Patients

et al. 2015

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“…56,57 Epicardial adiposity is associated with myocardial inflammation and dysfunction as well as CAD possibly as a consequence of paracrine actions that include increased production of reactive oxygen species, atherogenic and inflammatory cytokines. [57][58][59] EFT is clinically related to abdominal visceral adiposity, CAD, subclinical atherosclerosis, MetS and proinflammatory activity. 57,60,61 Visceral fat mass has been identified as an independent risk factor for NAFLD and EFT was also associated with the presence and progression of NAFLD.…”

Section: Epicardial Fat Thicknessmentioning

confidence: 99%

Atherosclerosis and Non-Alcoholic Fatty Liver Disease

Balta

2022

Angiology

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Non-alcoholic fatty liver disease (NAFLD) is a common disease defined by excess fat deposition in the liver. The course of NAFLD is not fully understood, however, some pathogenic mechanisms have been identified. Accumulation of fat in liver cells is associated with insulin resistance, central obesity, triglyceride accumulation in the liver and hepatic fatty acid metabolism dysregulation that cause steatosis. The other process leads to hepatocyte inflammation and necrosis, which leads to severe hepatic disease; non-alcoholic steatohepatitis. Many clinical studies have underlined the link between NAFLD and atherosclerosis. NAFLD may alter the balance lipid-glucose metabolism as well as increase the risk of hypertension and systemic inflammation. This results in a greater risk of vascular events. The present review considers the link between NAFLD and atherosclerosis.

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“…We read with interest the comments of Balta et al [1] regarding our study [2] that was recently published in this journal.…”

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confidence: 96%