Epibulbar Molluscum Contagiosum in Acquired Immune Deficiency Syndrome

Multiple molluscum contagiosum lesions of the limbus in a patient with HIV infection.

“…Histologically, we observed an inverted squamous cell papilloma with dysplastic change, marked mitotic activity, and koilocytosis in the cells near the tumour surface (Figs 2, 3). The superficial epithelial tumour cells were positive for anti-HPV antibody (Dako Corporation, USA) by immunohistochemical staining (Fig 4) 4 and 1 mm in diameter, were noted at 6 and 7 o'clock respectively (Fig 1). Another similar lesion, 2 mm in diameter, was present on the limbus in the right eye, at 3, 4, and 6 o'clock.…”

Adnexal and Anterior Segment Manifestations of HIV/AIDS

“…23,24 It can appear on either the skin or mucous membranes as single or multiple round, centrally umbilicated pearly papules of 2 to 3 mm in size. 2 When it occurs in HIV/AIDS patients, it can present as the initial manifestation of AIDS, 25 is often a marker for late stage disease 26 and presents with larger, more numerous, and rapidly growing lesions on the eyelids and skin.…”

Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review

“…Apart from the well-known eyelid involvement, chronic follicular conjunctivitis [14], corneal micropannus and epithelial keratitis have also been described. Across Europe, Asia and South America, 12 cases of solitary conjunctival lesions have been reported [1,6,12,21,26,27,43,54,57], but in only three instances were histopathological findings presented [1,6,43] [56], are successful in healthy individuals but tend to fail in HIV-infected patients due to recurrence [31].…”

“…The tendency towards recurrence in immunocompromised patients [47] implies that the immune system is important in the infection's containment and elimination. To date, several cases of ophthalmic MC in AIDS patients have been reported [7,30,32,47], but only two instances of unilateral [6] and DOI 10.1007/s00417-004-0925-8 one of multiple, bilateral [35] lesions of the conjunctiva have been described in such individuals. We herein describe a case of multiple, bilateral lesions of the perilimbal conjunctiva due to MC in an HIV-positive individual and discuss the evolution of the infection under the influence of highly active antiretroviral therapy (HAART), which, to the best of our knowledge, has not previously been described in the published literature.…”