Multiple molluscum contagiosum lesions of the limbus in a patient with HIV infection.

Merisier, H; Cochereau, Isabelle; Hoang–Xuan, T.; Toublanc, M.; Ruggeri, Corrado

doi:10.1136/bjo.79.4.393

Cited by 12 publications

(5 citation statements)

References 7 publications

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“…Basically, MC is more likely to arise on the eyelids [ 2 ] that are rich in blood vessels than on the cornea, which might be unaffected by the level of host immunity. Some reported MC arising on the corneal limbus [ 3 , 4 ] like in the present case; however, the CD4+ T-cell count was not described. In this case, MC occurred on the corneal limbus, when the immune system was severely weakened.…”

Section: Discussioncontrasting

confidence: 51%

“…Ophthalmic involvements usually manifest as single or multiple lesions on the skin of the eyelids [ 2 ]; however, MC arising from keratoconjunctival sites is extremely rare. Indeed, only a few case reports of MC on the corneal limbus have been documented, with clinical data solely provided by slit-lamp examination [ 3 , 4 ]. Therefore, clinical information on keratoconjunctival MC remains to be clarified.…”

Section: Introductionmentioning

confidence: 99%

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Molluscum contagiosum of the corneal limbus in an AIDS patient: a clinicopathological case report

2022

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Background Molluscum contagiosum, a pox virus infection, is likely to occur in the eyelid skin; however, corneal involvements by molluscum lesions are extremely rare. We report a case of molluscum contagiosum arising in the corneal limbus in an untreated AIDS patient, together with anterior segment optical coherence tomography (OCT) findings and histopathology of the excised tumor. Case presentation A 46-year-old man with AIDS was referred to our department for the management of an ocular lesion. Blood tests revealed an extremely low CD4+ T-cell count of 11 cells/μL, being strongly positive for anti-HIV antibody (591.36 S/CO) with a high copy number of HIV RNA (8070.0 × 100 copy/mL). Slit-lamp examination of his right eye showed a white nodule at the lower limbus. Anterior segment OCT findings of the nodule revealed a highly reflective elevated lesion, which was considered to involve the Bowman layer. The nodular lesion was excised from the limbus including the superficial corneal stroma, and then processed for histologic examination. Histopathology of the excised lesion showed acanthotic corneal epithelium containing swollen cells with eosinophilic inclusions known as molluscum bodies. He was diagnosed with molluscum contagiosum. Conclusions Anterior segment OCT findings provide useful information for morphological evaluations of and preoperative strategies against molluscum contagiosum.

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Molluscum contagiosum of the corneal limbus in an AIDS patient: a clinicopathological case report

2022

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“…16 A biopsy maybe needed in a few cases where it is difficult to differentiate between MCV infection and cryptococcosis. 17,18 Otherwise in cases of MCV, the diagnosis is mainly clinical and treatment involves applications of liquid nitrogen or topical agents like trichloroacetic acid and phenol. Incision with curettage, Cryotherapy and surgical excision are other modalities of treatment.…”

Section: ø Infections Virusesmentioning

confidence: 99%

Ocular Manifestations of Human Immunodeficiency Virus – A Review

Teotia¹

2012

DJO

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“…To our knowledge, only one other case of bilateral conjunctival MC in an HIV-positive patient has been published to date [35]. That patient was a 40-year-old African man who had first tested seropositive for HIV 4 years previously, at which time he had a CD4 T-lymphocyte count of 70 cells/ l. Infection was disseminated, with MC lesions being apparent on the face, the trunk and the genitalia; these had been treated repeatedly by curettage and cryotherapy within the preceding year.…”

Section: Follow-upmentioning

confidence: 99%

“…The tendency towards recurrence in immunocompromised patients [47] implies that the immune system is important in the infection's containment and elimination. To date, several cases of ophthalmic MC in AIDS patients have been reported [7,30,32,47], but only two instances of unilateral [6] and DOI 10.1007/s00417-004-0925-8 one of multiple, bilateral [35] lesions of the conjunctiva have been described in such individuals. We herein describe a case of multiple, bilateral lesions of the perilimbal conjunctiva due to MC in an HIV-positive individual and discuss the evolution of the infection under the influence of highly active antiretroviral therapy (HAART), which, to the best of our knowledge, has not previously been described in the published literature.…”

Section: Introductionmentioning

confidence: 99%

Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review

Schulz

Sarra

Koerner

et al. 2004

Graefe's Arch Clin Exp Ophthalmol

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Purpose: To present a rare case of bilateral conjunctival molluscum contagiosum (MC) in an HIV-positive individual who had unilateral lesion excision before induction of highly active antiretroviral therapy (HAART), and to discuss the pathophysiological consequences of immune restoration. Methods: Case report: A 40-year-old male Caucasian presented with atypical, bilateral lesions of the limbal conjunctiva due to MC. Before the induction of HAART, nodules in the left eye were excised whilst the single lesion in the right eye was left untouched. Results: The clinical diagnosis of conjunctival MC was confirmed histopathologically. Six months after the induction of HAART, the untouched lesion (right eye) had regressed and there was pronounced local injection of the conjunctiva. MC lesions did not recur after excision (left eye), and signs of inflammation were absent. Conclusion: Conjunctival MC is rare and associated with immune deficiency. To the best of our knowledge, the presented case is the first reported instance of bilateral, multi-lesional MC of the conjunctiva in an HIVpositive patient undergoing HAART. Attention must be paid to the possible complications associated with the restoration of immunocompetence.

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Multiple molluscum contagiosum lesions of the limbus in a patient with HIV infection.

Cited by 12 publications

References 7 publications

Molluscum contagiosum of the corneal limbus in an AIDS patient: a clinicopathological case report

Molluscum contagiosum of the corneal limbus in an AIDS patient: a clinicopathological case report

Ocular Manifestations of Human Immunodeficiency Virus – A Review

Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review

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