Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review

Schulz, Dominic; Sarra, Gian-Marco; Koerner, Ulla B.; Garweg, Justus G.

doi:10.1007/s00417-004-0925-8

Cited by 14 publications

(5 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, immune restoration with ART results in lesion resolution although MC has been seen as a manifestation of IRIS (220)(221)(222)(223)(224)(225)(226). ART should be continued even if IRIS-related MC is present.…”

Section: Molluscum-molluscum Contagiosum (Mcmentioning

confidence: 99%

HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management

et al. 2019

View full text Add to dashboard Cite

Anti-retroviral therapy (ART) has revolutionized the treatment and prognosis of people living with HIV (PLHIV). With increased survival and improved overall health, PLHIV are experiencing dermatologic issues both specific to HIV and common to the general population. In this new era of ART, it is crucial for dermatologists to have a strong understanding of the broad range of cutaneous disease and treatment options in this unique population. In this review, we outline the most common skin diseases in PLHIV, including HIV-associated malignancies, inflammatory conditions, and infections, and focus on the role of ART in altering epidemiology, clinical features, diagnosis, and treatment of cutaneous conditions.

show abstract

Section: Molluscum-molluscum Contagiosum (Mcmentioning

confidence: 99%

HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management

et al. 2019

View full text Add to dashboard Cite

show abstract

“…HAART has been shown to completely cure a case of conjunctival MC in an AIDS patient. [8] Ritonavir, another antiretroviral drug, has been known to resolve lesions of MC in AIDS patient. [9] The immune response inflammatory syndrome (IRIS) is an inflammatory state which occurs in AIDS patients and where the patient's condition clinically worsens after institution of HAART.…”

Section: Discussionmentioning

confidence: 99%

Disfiguring molluscum contagiosum in a HIV-positive patient responding to antiretroviral therapy

et al. 2009

View full text Add to dashboard Cite

Molluscum contagiosum (MC) is caused by a double stranded DNA virus belonging to the pox virus family. MC lesions are usually pearly, dome shaped, small, discrete lesions with central umbilication. In HIV-positive patients atypical varieties are found. They may be large or nonumbilicated. Individual papules may join to form the agminate variety. This form is rare. Lesions of MC in healthy immunocompetent patients may occur at any part of the body including face, trunk, and limbs. Sexually active adults have lesions usually on the genitalia, pubis, and inner thigh, rarely on the face and scalp. We present a case of agminate MC occurring in a patient with acquired immunodeficiency disease responding to highly active antiretroviral therapy.

show abstract

“…Treatment options include incision and curettage, liquid nitrogen, trichloroacetic acid or cryotherapy. However, patients on HAART may undergo spontaneous resolution of Molluscum contagiosum within six months (52,53).…”

Section: Other Infectionsmentioning

confidence: 99%

Ophthalmic Manifestations of HIV in the Highly Active Anti-Retroviral Therapy Era

Mowatt

2014

West Indian Med J

View full text Add to dashboard Cite

HIV-related eye disease can be classified as retinal HIV microangiopathy, opportunistic infections, neuro-ophthalmic manifestations and unusual malignancies. There is a 52-100% lifetime accumulative risk of HIV patients developing eye problems. Seventy-seven per cent of patients with ocular manifestations of HIV had CD4 counts < 200 cells/μL. Cytomegalovirus (CMV) is the most prevalent opportunistic infection, however, Africa has a low incidence of this, and more commonly squamous cell carcinoma, compared to the western hemisphere. Due to highly active antiretroviral therapy (HAART), the anti-CMV therapy may be discontinued if the CD4+ T cell count is > 100 cells/μL for a minimum of three months. Despite HAART, patients with a CD4 count < 50 cells/μL have a similar risk of developing CMV retinitis as compared to the pre-HAART era. Opportunistic infections include CMV, herpetic retinopathy (progressive outer retinal necrosis - PORN), less commonly toxoplasmosis, pneumocystis and cryptococcus. Malignancies associated with HIV include Kaposi's sarcoma and conjunctival squamous cell carcinoma. Cranial nerve palsies, optic disc swelling and atrophy are characteristic neuro-ophthalmic features. They usually occur secondary to meningitis/encephalitis (from cryptococcus and tuberculosis). With the advent of HAART, new complications have developed in CMV retinitis: immune recovery uveitis (IRU) and cystoid macula oedema (CMO). Immune recovery uveitis occurs in 71% of patients if HAART is started before the induction of the anti-CMV treatment. However, this is reduced to 31% if HAART is started after the induction treatment. Molluscum contagiosum and Kaposi's sarcoma can spontaneously resolve on HAART. Highly active anti-retroviral therapy has reduced the frequencies of opportunistic infections and improved the remission duration in HIV patients.

show abstract

Evolution of HIV-1-related conjunctival molluscum contagiosum under HAART: report of a bilaterally manifesting case and literature review

Cited by 14 publications

References 53 publications

HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management

HIV-Related Skin Disease in the Era of Antiretroviral Therapy: Recognition and Management

Disfiguring molluscum contagiosum in a HIV-positive patient responding to antiretroviral therapy

Ophthalmic Manifestations of HIV in the Highly Active Anti-Retroviral Therapy Era

Contact Info

Product

Resources

About