Eosinophilic Peritonitis – Hypothesis

Characterization of Eosinophils in a Continuous Ambulatory Peritoneal Dialysis Patient with Eosinophilic Peritonitis

“…Several hypotheses for the cause of eosinophilic peritonitis have been discussed [2,11,12]. Plastic and plasticizers in dialysate bags and tubing have been implicated.…”

Pathophysiology of Peritoneal Fluid Eosinophilia in Peritoneal Dialysis Patients

“…Mechanical trauma during insertion of catheter, hypersensitivity reaction to ethylene oxide and other sterilants used in the preparation of dialysate bags [20, 21], plasticizers, additives, impurities, decomposition products and reaction products, still unidentified compounds released from polyvinyl chloride bags and iodine solution used for continuous ambulatory peritoneal dialysis with possible exposure of the peritoneal membrane to iodine, and mechanical irritant action of large volumes of fluid on the peritoneum have all been implicated in the induction of peritoneal fluid eosinophilia [22]. Saline lavage alone has been shown to be a sufficient stimulus for peritoneal eosinophil production in animal models [23].…”

“…Resolution of peritoneal fluid pleocytosis correlates temporarily with absorption of subdiaphragmatic air [24]. Allergic reaction to intraperitoneally administered heparin [25]and antibiotics for the treatment of bacterial peritonitis [22]could be associated with the development of peritoneal fluid eosinophilia. Uremia per se [26], viral infection [27], Paecilomyces variotti infection [28], and Aspergillus niger infection [29]can cause peritoneal fluid eosinophilia.…”

Peritoneal fluid eosinophilia

“…While it may not explain all of our dilemmas, it probably signals a paradigm shift in our The recruitment of eosinophils into the peritoneum approach to this intriguing phenomenon. during peritoneal dialysis is not explained solely by hypersensitivity reactions to constituents of the peritoneal dialysis systems and medications [5] Introduction tumour lysis syndrome. Likewise, the improvement of cryopreservation and marrow infusion modalities perAcute renal failure (ARF ) after bone marrow transmitted to largely avoid today the uncommon cases of plantation (BMT ) is a frequent event, with a 30-80% ARF during the 3 first days [3].…”

“…Whichever the renal dysfunction mechanism, occlusive disease, but none of them have proved to be the aetiological and therapeutic approaches have effective. Haemodialysis is rarely required, but if it is to take into account the haematological context: allothe risk of hypovolaemia should be borne in mind [5]. genic or autologous BMT, conditioning therapy, haematological risk factors, graft-versus-host-disease (GVHD), underlying diseases recurrence-risk, age, Period 2 veno-occlusive disease.…”