Pathophysiology of Peritoneal Fluid Eosinophilia in Peritoneal Dialysis Patients

Ejaz, A. Ahsan; Fitzpatrick, Peter M.; Durkin, Alan J.; Wasiluk, Andrzej; Haley, William E.; Goalen, Melissa J.; Ing, Todd S.; Zachariah, Prince K.

doi:10.1159/000045266

Cited by 27 publications

(51 citation statements)

References 19 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The peritoneal cavity is a major reservoir of eosinophils under homeostatic and inflammatory states [18] and where eosinophils become activated and cause effects on the peritoneum. Hypersensitivity and intraperitoneal inflammatory reactions induced by PD drive the activation of Th2 cells and other inflammatory cells [19,20], releasing cytokines including IL-5, granulocytemacrophage colony-stimulating factor (GM-CSF), and IL-3, which trigger eosinophil proliferation, activation, and chemotaxis to the peritoneum [21]. There are several possible changes to the peritoneum induced by activated eosinophils.…”

Section: Discussionmentioning

confidence: 99%

Higher Eosinophils Predict Death-Censored Technique Failure in Peritoneal Dialysis Patients

Yang

Fan

et al. 2020

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Introduction: Eosinophilia (eosinophil fraction of leukocytes >5%), an indicative parameter for bioincompatibility in various circumstances, is well established in hemodialysis. However, change in eosinophil count (EOC) and its association with death-censored technique failure among peritoneal dialysis (PD) patients remain unclear. Methods: We compared eosinophils before and after PD initiation among 1,432 eligible continuous ambulatory PD patients regularly followed up in our PD center during 2007-2018. Risk factors of earlystage eosinophilia were examined by the logistic regression test. The relationship of early-stage eosinophilia and EOC with death-censored technique failure was examined using the Cox proportional hazards model for overall patients and for men and women separately. Results: After PD initiation, the EOC and percentage of patients with eosinophilia were significantly increased compared with baseline. Being male (odds ratio [OR]: 2.26; 95% confidence interval [CI]: 1.55-3.31; p < 0.001) and higher EOC at baseline (100 cells/μL increase, OR: 1.62; 95% CI: 1.45-1.82; p < 0.001) were risk factors of early-stage eosinophilia after PD initiation. During follow-up, 204 death-censored technique failures were recorded. In fully adjusted models, each with 100 cells/μL increase in EOC, the adjusted hazard ratios (HRs) of technique failure were 1.11 (95% CI: 1.03-1.20; p = 0.009) in the whole cohort, 1.29 (95% CI: 1.10-1.51; p = 0.002) in women, and 1.07 (95% CI: 0.97-1.17; p = 0.196) in men. Eosinophilia was significantly associated with the risk of technique failure for women (HR: 2.24; 95% CI: 1.07-4.70; p = 0.033), which was especially significant for women aged <55 years (HR: 7.61; 95% CI: 1.88-30.90; p = 0.005). Conclusion: EOC was increased significantly after PD initiation, and increased numbers of eosinophils were associated with higher death-censored technique failure in PD patients, especially women.

show abstract

Section: Discussionmentioning

confidence: 99%

Higher Eosinophils Predict Death-Censored Technique Failure in Peritoneal Dialysis Patients

Yang

Fan

et al. 2020

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…While eosinophils in pleural effusions have been described in several clinical settings, they are less commonly found in peritoneal fluids. Eosinophils in peritoneal fluid specimens have been mainly described in patients undergoing peritoneal dialysis with or without concurrent intra‐abdominal infections …”

Section: Discussionmentioning

confidence: 99%

Cytomorphological changes induced by intraperitoneal chemotherapy present important diagnostic pitfalls in peritoneal fluid cytology

Mok

Nga

2017

Cytopathology

View full text Add to dashboard Cite

show abstract

“…39 When it is abundant, peritoneal fluid eosinophilia can induce a turbid appearance of the peritoneal fluid, more often found on the nocturnal exchange when CAPD is utilized. Idiopathic eosinophilic peritonitis is usually encountered in the first few months of peritoneal dialysis and is considered a hypersensitivity reaction to certain dialysis system components (catheter or solution), 40 or to air trapped intraperitoneally following catheter placement. It is generally asymptomatic and with a spontaneously favorable outcome over a few days.…”

Section: Cloudy Dialysatementioning

confidence: 99%

When the color of peritoneal dialysis effluent can be used as a diagnostic tool

Dossin

Goffin

2018

Seminars in Dialysis

View full text Add to dashboard Cite

Peritoneal dialysis (PD) effluent is normally transparent. A change in its appearance may be the first indication of an intra- or extraperitoneal abnormality which may or may not be related to the peritoneal dialysis technique itself. What diagnosis should be considered when PD effluent turns on red, orange, cloudy, milky white, green, yellow, purple or black in color? After review of the literature, we propose a differential diagnosis, as well as some management recommendations, for specific abnormal color presentations of the PD effluent.

show abstract

Pathophysiology of Peritoneal Fluid Eosinophilia in Peritoneal Dialysis Patients

Cited by 27 publications

References 19 publications

Higher Eosinophils Predict Death-Censored Technique Failure in Peritoneal Dialysis Patients

Higher Eosinophils Predict Death-Censored Technique Failure in Peritoneal Dialysis Patients

Cytomorphological changes induced by intraperitoneal chemotherapy present important diagnostic pitfalls in peritoneal fluid cytology

When the color of peritoneal dialysis effluent can be used as a diagnostic tool

Contact Info

Product

Resources

About