Characterization of Eosinophils in a Continuous Ambulatory Peritoneal Dialysis Patient with Eosinophilic Peritonitis

Sligh, Julie M.; Gottlieb, Steven J.; Domoto, Douglass T.; Slavin, Raymond G.

doi:10.1159/000235425

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Collectively, our findings imply that recruited eosinophils are in an activated state (5-7). This is in line with previous studies reporting on the increased proportion of hypodense, that is, activated eosinophils in PF from patients with PFE (11). Whether the activation state results from transmigration through endothelium, alone or in combination with locally produced inflammatory mediators, cannot be stated clearly.…”

Section: Discussionsupporting

confidence: 93%

Phenotypic Alterations of Recruited Eosinophils in Peritoneal Fluid Eosinophilia

et al. 2000

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Objective To characterize eosinophils and soluble factors in effluent from continuous ambulatory peritoneal dialysis (CAPD) patients and connect these findings to related conditions with eosinophilic accumulation. Patients Three newly started CAPD patients, two with peritoneal fluid eosinophilia (PFE) and one with bacteria-induced peritonitis. One patient with PFE was followed up for 10 visits during a 7-month period. Methods Leukocytes were analyzed in dialysate and peripheral blood from the patients, by flow cytometry, and soluble mediators by ELISA or CAP technique. Results We found an increased number of neutrophils in the effluent from the patient with bacteria-induced peritonitis; accumulation of eosinophils in combination with negative cultures was noted in the patients with PFE. Increased levels of interleukin (IL)-5 and eosinophil cationic protein, but equal levels of eotaxin, were found in effluent from the PFE patients compared to the patient with neutrophilia. Peritoneal fluid eosinophils were activated by means of EG2, CD11b, CD9, and CD69 expression. Compared to blood eosinophils, the cytokine receptors for IL-5 and granulocyte-macrophage colony-stimulating factor, but not IL-3, were down regulated. Conclusion The finding of activated eosinophils in combination with IL-5 and eotaxin in PFE indicates existing similarities between PFE and conditions found during recruitment of eosinophils in allergic inflammatory responses.

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Section: Discussionsupporting

confidence: 93%

Phenotypic Alterations of Recruited Eosinophils in Peritoneal Fluid Eosinophilia

et al. 2000

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“…In many cases, a history of atopy and accompanying immunoglobulin E (IgE) elevation can be detected 6,10,11 . The level of mechanical trauma to the peritoneum depends on the catheter placement method 24,25 . In the study published by Jo et al in 2007, peritoneal eosinophilia and idiopathic EP were infrequent (6.3% and 2.1%, respectively) in CAPD patients in the first 6 months following percutaneous catheter placement due to less severe mechanical trauma or irritation.…”

Section: Discussionmentioning

confidence: 99%

“…6,10,11 The level of mechanical trauma to the peritoneum depends on the catheter placement method. 24,25 In the study published by Jo et al in 2007, peritoneal eosinophilia and idiopathic EP were infrequent (6.3% and 2.1%, respectively) in CAPD patients in the first 6 months following percutaneous catheter placement due to less severe mechanical trauma or irritation. Therefore, innovations in the quality of PD materials or connectology might be associated with a reduced incidence of EP.…”

Section: Prevalencementioning

confidence: 99%

Eosinophilic peritonitis in children undergoing maintenance peritoneal dialysis: A case report and literature review

Kenan

Büyükkaragöz

Leventoğlu

et al. 2022

Seminars in Dialysis

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Eosinophilic peritonitis (EP) constitutes a significant number of culture‐negative peritonitis cases that can affect 16–60% of the patients who are treated with maintenance peritoneal dialysis (PD). Although it is mainly considered to be the hypersensitivity response of the peritoneum to foreign substances, it can also develop following culture‐positive peritonitis attacks. Besides the presence of more than 100 white blood cells (WBC)/ml, the diagnosis is made with the high number of eosinophils in the dialysate fluid (>10%), usually accompanied by peripheral eosinophilia. In this study, a 12‐year‐old male patient, who was diagnosed as EP as early as in the first week of PD catheter placement and treated with systemic antihistamines was reported. Additionally, clinical aspects and treatment modalities of EP are presented with a detailed literature review. Although EP is usually a self‐limiting clinical manifestation with a benign outcome, it can be overlooked due to the lack of a routine reporting of the count and percentage of peritoneal eosinophils in most centers. For this reason, a detailed examination in culture‐negative peritonitis cases for EP in order to avoid unnecessary antibiotic use for these patients should be the strategy.

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“…Peritoneal eosinophilia is frequently benign and often resolves without intervention [8], although occasionally it may lead to peritoneal protein loss and hypoalbuminaemia [9]. It is important it be identified because unnecessary antibiotic treatment may be given or, conversely, should it persist, may mask genuine infection.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic peritonitis in children on chronic peritoneal dialysis

Quinlan¹,

Cantwell²,

Rees³

2009

Pediatr Nephrol

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Eosinophilic peritonitis is a response of the peritoneum to foreign substances. It presents as cloudy dialysate and may be missed because not all laboratories report the eosinophil count, giving only the total number of polymorphonuclear cells. Over a 2-year period, eight children developed 13 episodes of eosinophilic peritonitis. Three episodes were asymptomatic other than cloudy fluid, five followed surgery and two were associated with gastroenteritis. Despite recurrent episodes, there were no adverse outcomes, although a raised peritoneal eosinophil count persisted in most cases. Eosinophilic peritonitis is under-diagnosed and may lead to unnecessary antibiotic therapy.

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Characterization of Eosinophils in a Continuous Ambulatory Peritoneal Dialysis Patient with Eosinophilic Peritonitis

Cited by 3 publications

References 8 publications

Phenotypic Alterations of Recruited Eosinophils in Peritoneal Fluid Eosinophilia

Phenotypic Alterations of Recruited Eosinophils in Peritoneal Fluid Eosinophilia

Eosinophilic peritonitis in children undergoing maintenance peritoneal dialysis: A case report and literature review

Eosinophilic peritonitis in children on chronic peritoneal dialysis

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