Eosinophilic granuloma of the mandible

Abstract

Eosinophilic granuloma (EG) is a rare histiocytic disorder resulting from clonal proliferation of Langerhans cells. Eosinophilic granuloma, the most benign of the three entities of Langerhans cell histiocytosis, may be multiple or solitary. This lesion can affect any bones but commonly involves the mandible when the jaws are affected. It is difficult to make a correct diagnosis on it without proof of a pathological diagnosis, which correlates with the diverse clinical and radiographic presentations of EG in the jaws. This report describes a case of unifocal EG of the mandible occurring in a 6-year-old boy whose initial presentation led to confusion of any solitary bony lesion. A final diagnosis of EG was established after histopathological examination of the biopsy specimen.

Multifocal eosinophilic granuloma with femoral epiphyseal lesion mimicking an aneurysmal bone cyst

“…Eosinophilic granuloma is a type of benign bone tumor, and the mildest subtype of Langerhans cell histiocytosis. This condition has been described in many different anatomic locations within the human body [2 , 3 , [6] , [7] , [8] , 11 , 12] , and may present either in a single or multiple foci. This disease typically affects the axial skeleton, however, may also affect long bones with the majority of lesions occurring in the diaphysis [1] .…”

“…Eosinophilic granuloma (EG) is a benign tumor-like disorder characterized by abnormal proliferation of antigen-presenting cells of myeloid dendritic origin known as Langerhans cells [1] . Along with Hand-Schuller-Christian disease and Letterer-Siwe disease, they compose the Langerhans cell histiocytosis; eosinophilic granuloma being the mildest and most common subtype [2 , 3] . EG frequently presents as a solitary lesion; even though a polyostotic form has been described.…”

Eosinophils in Oral Disease: A Narrative Review

“…Radiologically, it manifests as teeth resorption, with the teeth appearing to be floating in the air. A histopathological examination reveals the scattered sheets of eosinophilic infiltrates [31,32].…”