Multifocal eosinophilic granuloma with femoral epiphyseal lesion mimicking an aneurysmal bone cyst

Davis, Ty A.; Mosquea, Thelma R. Jimenez; Belzarena, Ana C.

doi:10.1016/j.radcr.2022.08.024

Cited by 2 publications

(2 citation statements)

References 16 publications

(25 reference statements)

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“…Skull EC should also be distinguished from eosinophilic granuloma (EG), aneurysmal bone cyst (ABC), giant cell tumor of bone (GCBT), fibrous dysplasia of bone (FDB), and other tumors on radiography. EG typically show pathological changes as granulation tissue replacing normal bone tissue, skull destruction with or without soft tissue mass, residual small bone pieces in the lesion, typically “button” type dead bone, and contrast-enhanced scanning shows significant strengthening of soft-tissue masses ( 13 ). ABC is a benign neoplastic lesion of unknown etiology that tends to occur in long tubular bones and the spine ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

“…EG typically show pathological changes as granulation tissue replacing normal bone tissue, skull destruction with or without soft tissue mass, residual small bone pieces in the lesion, typically “button” type dead bone, and contrast-enhanced scanning shows significant strengthening of soft-tissue masses ( 13 ). ABC is a benign neoplastic lesion of unknown etiology that tends to occur in long tubular bones and the spine ( 13 ). CT often manifests eccentric dilated osteolytic destruction, multiple cystic low-density areas, and bony separation in the lesion, while MRI showed cystic multilocular lesions, in which an obvious liquid-fluid level was visible, and there was a low signal ring at the edge of the lesion on T1WI and T2WI scans, and the spacing of the cyst wall and lesion was strengthened after enhanced scanning ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

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A case of intradiploic epidermoid cyst

Zhao¹,

Lan²

2023

Quant Imaging Med Surg

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A case of intradiploic epidermoid cyst

Zhao¹,

Lan²

2023

Quant Imaging Med Surg

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Langerhans cell histiocytosis with aneurysmal bone cyst-like changes: a case-based literature review

Darrow

Sharma

2023

Childs Nerv Syst

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Background Langerhans cell histiocytosis (LCH) is a neoplastic transformation of myeloid precursors that commonly presents as an osteolytic lesion of the long or flat bones in children. Aneurysmal bone cysts (ABC) are benign neoplasms that frequently affect the metaphysis of long bones and the spine, often revealing a rapidly expansile lesion with fluid-fluid levels. LCH with secondary ABC-like changes is a rare condition that has only been reported five times, with two presentations in the cranium. The aim of this paper is to review the etiology, clinical and radiographic presentations, and treatment of this condition, as well as to present a novel case on the topic. Case description We describe a 5-year-old boy with a rapidly growing head mass and eye pain resulting in a diagnosis of LCH with secondary ABC-like changes. Radiography demonstrated an expansile, lytic lesion of the left parietal bone with fluid-fluid levels. A confirmatory diagnosis was made through histopathology, demonstrating an inflammatory, histiocytic infiltrate staining positive for CD1a, CD68, CD207 (Langerin), and S-100. The lesion was surgically excised, and the patient recovered without any complications. Conclusion We present a novel case of LCH with secondary ABC-like changes managed with surgical excision. While a radiographic workup with multiple imaging modalities is helpful for diagnosis, a thorough immunohistochemical analysis is essential as imaging characteristics are variable and nonspecific. Furthermore, surgical excision should be considered first-line treatment for lesions involving the skull in surgically accessible areas as it is curative, alleviates symptoms, and allows for histopathological diagnosis.

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Multifocal eosinophilic granuloma with femoral epiphyseal lesion mimicking an aneurysmal bone cyst

Cited by 2 publications

References 16 publications

A case of intradiploic epidermoid cyst

A case of intradiploic epidermoid cyst

Langerhans cell histiocytosis with aneurysmal bone cyst-like changes: a case-based literature review

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