Eosinophilic Gastroenteritis with Splendore-Hoeppli Material in the Ferret (<i>Mustela putorius furo</i>)

Fox, James G.; Palley, Lori S.; Rose, Rebecca

doi:10.1177/030098589202900103

Cited by 25 publications

(13 citation statements)

References 10 publications

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“…Histopathologically, the diffuse form of eosinophilic infiltration and multiple granulomas in the cecum in this case appeared to be similar to that described in other species (Fox et al, 1992;Hendrick, 1981;Pass and Bolton, 1982). This was characterized by prominent infiltration by eosinophils with resultant thickening of the affected portion of the cecum.…”

Section: Discussionsupporting

confidence: 83%

The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat

Li¹,

Bae

Kim³

et al. 2014

J. Toxicol. Sci.

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-Spontaneous multiple granulomas were present in the animal under the SPF condition and without chemical treatment, in a 19-week-old male Sprague-Dawley control-group rat. Here we describe multiple granulomas and prominent diffuse infiltration by eosinophils in the cecal submucosa, and arteritis in the mesenteric arteries. The multiple granulomas were characterized by central eosinophilic degeneration or necrosis, prominent eosinophils, many multi-nucleated giant cells and abundant fibroblasts. They were restricted to the cecal submucosa. The mesenteric arteritis consisted of fibrinoid necrosis of the intima and media, intense inflammatory cell infiltration and fibrosis in the arterial wall. An affected artery in the cecum was continuous with the mesenteric artery. The foregoing tissue changes in this rat correlate with the high absolute blood eosinophil count found in this animal.

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Section: Discussionsupporting

confidence: 83%

The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat

Li¹,

Bae

Kim³

et al. 2014

J. Toxicol. Sci.

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“…11,14 In particular, the diffuse forms of gastroenteritis and mesenteric lymphadenitis are similar to the lesions described in ferrets, cats, horses, and dogs. 3,4,9,10 Many eosinophilic inflammatory lesions were found in the mes rats, yet cardiac lesions could not be found. Cardiac lesions are the most common feature of the chronic hypereosinophilia, including HES seen in humans.…”

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confidence: 95%

“…It has been reported in humans, ferrets, cats, horses, and dogs. 1,[3][4][5][6]9,10,14 However, details of the pathology and pathogenesis of HES are unclear.…”

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confidence: 99%

“…This eosinophilic material is thought to be Splendore-Hoeppli material because the characteristics are similar to those described in ferrets. 3 It is suggested that inflammation is caused by the cytotoxicity of mediators such as the eosinophilic granule proteins that are released from the eosinophils. 11,14 In particular, the diffuse forms of gastroenteritis and mesenteric lymphadenitis are similar to the lesions described in ferrets, cats, horses, and dogs.…”

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confidence: 99%

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Systemic and Eosinophilic Lesions in Rats with Spontaneous Eosinophilia (mesRats)

Muto¹,

Hayashi²,

Matsushita³

et al. 2001

Vet Pathol

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Abstract. The mes rat is from an inbred mutant colony of rats with spontaneous eosinophilia. In order to investigate the pathogenesis of the mes rat, the histopathology and hematology for 76 mes rats were examined at several weeks of age. Tissue eosinophilia developed at 8 weeks of age when the blood eosinophil was 500 cells per microliter or more. Subsequently, eosinophilia progressed with age, and splenic eosinophilopoiesis and erythropoiesis appeared simultaneously. Many inflammatory lesions were induced after 10 weeks of age when the blood eosinophils became 1,000 cells per microliter or more. Gastroenteritis and mesenteric lymphadenitis were seen in 44 of 47 (94%) and 31 of 47 (66%) rats, respectively, after 10 weeks of age. Aortitis that deteriorated with age was found in 19 of 39 (49%) rats after 12 weeks of age. Hepatic fibrosis was found in four rats that exhibited severe eosinophilia and anemia. These results are comparable to the features of a hypereosinophilic syndrome in humans and other animals.

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“…[7][8][9][10] Little is known about the cause and clinical behavior of this disorder, making recommendations for treatment difficult and the prognosis unclear. Surgical resection of the mass or treatment with corticosteroids and antiparasiticides has resulted in variable but often poor outcomes.…”

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confidence: 99%

Idiopathic Eosinophilic Masses of the Gastrointestinal Tract in Dogs

Lyles

Panciera

Saunders

et al. 2009

Veterinary Internal Medicne

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Background: Eosinophilic inflammation of the gastrointestinal tract of dogs occurs in numerous disorders, typically resulting in diffuse intestinal thickening. Rarely, eosinophilic masses have been reported.Objective: Describe a series of dogs with 1 or more idiopathic eosinophilic gastrointestinal masses (IEGM) to better characterize the clinical features, treatment, and prognosis.Animals: Seven dogs with 1 or more gastrointestinal masses composed primarily of eosinophilic infiltrates for which no underlying cause was found.Methods: Retrospective case series.Results: Rottweilers and purebred, large breed dogs predominated. Dogs were middle-aged and typically had chronic signs of upper or lower gastrointestinal disease. Decreased appetite, vomiting, and evidence of gastrointestinal hemorrhage were present in the majority of cases. An abdominal or rectal mass was frequently noted on physical examination. Common laboratory abnormalities included peripheral eosinophilia, mature neutrophilia, hypoproteinemia, and hypocholesterolemia. The masses were histologically composed of moderate to severe eosinophilic infiltrates, which were often transmural and accompanied by fibrosis. All dogs treated with surgery alone died of complications of their disease. Treatment with corticosteroids and ivermectin improved clinical signs, caused resolution of eosinophilic infiltrates, and prolonged survival in most dogs treated medically.Conclusions and Clinical Importance: These findings suggest that the prognosis for dogs with IEGM may be good when recognized and managed appropriately. When surgery is performed, medical treatment should also be added.

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Eosinophilic Gastroenteritis with Splendore-Hoeppli Material in the Ferret (Mustela putorius furo)

Cited by 25 publications

References 10 publications

The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat

The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat

Systemic and Eosinophilic Lesions in Rats with Spontaneous Eosinophilia (mesRats)

Idiopathic Eosinophilic Masses of the Gastrointestinal Tract in Dogs

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