Systemic and Eosinophilic Lesions in Rats with Spontaneous Eosinophilia (<i>mes</i>Rats)

Muto, Shin-ichi; Hayashi, Masahiro; Matsushita, Norifumi; Momose, Yasunori; Shibata, Noriyuki; Umemura, Tomonari; Matsumoto, Kiyoshi

doi:10.1354/vp.38-3-346

Cited by 13 publications

(29 citation statements)

References 14 publications

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“…From the results in previous (Matsumoto et al 2000, Muto et al 2001) and present studies, it became apparent that the MES rats to F16 generations showed similar degrees of eosinophilia in blood samples collected from different generations. The onset of eosinophilia in the MES rats was apparent by 8 weeks of age and the eosinophilia dramatically increased with age up to 20 weeks.…”

Section: Discussionsupporting

confidence: 64%

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Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyser

et al. 2005

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The Matsumoto Eosinophilic Shinshu (MES) rat originated from an inbred mutant colony of rats with spontaneous eosinophilia. As part of an investigation of the pathogenesis of the MES rat, we examined the haematology data for 106 males and 88 females and age-associated changes using an automated haematology analyser, flow cytometric analysis and morphological examination. The data at 10 weeks of age showed the MES rats had higher counts for eosinophils and neutrophils, slightly higher counts for lymphocytes, monocytes, basophils, and large unstained cells (LUCs), and slightly lower values for the erythrocytic parameters when compared with Sprague-Dawley (SD) rats. In data for MES rats aged 8 to 20 weeks, eosinophil counts increased with age up to 20 weeks together with some increased neutrophil counts. After 11 weeks of age, counts for lymphocytes, monocytes, basophils, and LUCs in the MES rats were also slightly increased. In female MES rats, flow cytometric analysis showed increased counts for pan-T+ cells, but blasts, abnormal granulocytes and lymphocytes were not detected morphologically. The MES rat characterized by the haematological findings could be a useful animal model for studies of hypereosinophilia.

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Section: Discussionsupporting

confidence: 64%

“…These features are comparable to the features of HES in humans and other species. Therefore, it is probable that the MES rat could be a useful animal model for studies of eosinophilia, HES, or both (Matsumoto et al 2000, Muto et al 2001). …”

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Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyser

et al. 2005

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“…Matsumoto Eosinophilia Shinshu (MES) is a rat strain that develops eosinophilia spontaneously [3][4][5][6]8]. In these rats a marked increase in peripheral blood eosinophils (>500/µl) occurs at about 9 weeks of age, with eosinophilia progressing with age until the number of eosinophils eventually exceeds the level that is characteristic of human hypereosinophilia (>1,500/µl).…”

Section: Abstract: Matsumoto Eosinophilia Shinshu (Mes) Is a Rat Stramentioning

confidence: 99%

“…

Abstract: Matsumoto Eosinophilia Shinshu (MES) is a rat strain that spontaneously develops eosinophilia and eosinophil-related inflammatory lesions in many organsThe etiology of the majority of idiopathic HES cases and the mechanisms of eosinophilopoiesis remain poorly understood.Matsumoto Eosinophilia Shinshu (MES) is a rat strain that develops eosinophilia spontaneously [3][4][5][6]8]. In these rats a marked increase in peripheral blood eosinophils (>500/µl) occurs at about 9 weeks of age, with eosinophilia progressing with age until the number of eosinophils eventually exceeds the level that is characteristic of human hypereosinophilia (>1,500/µl).

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A Third Locus for Eosinophilia on Chromosome 1 of the MES Rats

2006

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Matsumoto Eosinophilia Shinshu (MES) is a rat strain that spontaneously develops eosinophilia and eosinophil-related inflammatory lesions in many organsThe etiology of the majority of idiopathic HES cases and the mechanisms of eosinophilopoiesis remain poorly understood.Matsumoto Eosinophilia Shinshu (MES) is a rat strain that develops eosinophilia spontaneously [3][4][5][6]8]. In these rats a marked increase in peripheral blood eosinophils (>500/µl) occurs at about 9 weeks of age, with eosinophilia progressing with age until the number of eosinophils eventually exceeds the level that is characteristic of human hypereosinophilia (>1,500/µl). The abnormal eosinophilic proliferation takes place in the bone marrow and is associated with enlargement of the mesenteric lymph nodes. This enlargement is the result of infiltration of eosinophils into the lymph nodes, Eosinophil is a type of white blood cell that plays an important role in the innate immune system, especially in counteracting parasitic infections. The normal range for blood eosinophils is 40-400/µl in humans and 15-120/µl in rats. The term eosinophilia refers to conditions in which abnormally high numbers of eosinophils are found in either blood (600-1,500/µl) or tissues [1]. Eosinophilia may occur in a number of diseased conditions, which include parasitic infections, allergies, collagen vascular diseases, and neoplastic disorders. Another morbid condition distinct from these secondary eosinophilias, idiopathic hypereosinophilic syndrome (idiopathic HES), is a condition in which eosinophilia persists without any apparent etiology [7].

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“…The Matsumoto Eosinophilia Shinshu (MES) rat strain has a genetic predisposition to develop eosinophilia [18,[20][21][22][23][24]34]. In these rats, a marked increase in peripheral blood eosinophils (>500/µl) occurs at about nine weeks of age, with eosinophilia progressing with age until the number of eosinophils eventually exceeds the level that is characteristic of human idiopathic hypereosinophilia (>1,500/µl).…”

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confidence: 99%

Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cybames Rats Are on Chromosomes 9, 5, and 1

et al. 2011

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Abstract:The Matsumoto Eosinophilia Shinshu (MES) rat strain develops hereditary blood eosinophilia due to the mutant Cyba mes gene. In contrast, BN.MES-Cyba mes congenic rats, in which the mutant Cyba mes gene introduced into the background of the BN strain, have a normal blood eosinophil level despite showing robust proliferation of eosinophils in the bone marrow. However, the congenic rats manifest focal necrosis with eosinophilic infiltration in the liver, a phenotype rarely observed in the original MES rat strain. To elucidate the genetic basis for the strain differences, (MES × BN.MES-Cyba mes )F 2 rats were bred, and genetic analyses of phenotypes for eosinophilia were performed. Blood and bone marrow eosinophil levels in the F 2 rats showed broad distributions, suggesting that the traits were under the influence of multiple genes. Genetic association studies revealed that BN-derived marker loci on chromosomes 9 and 5 were responsible for the increase in eosinophil level in the bone marrow, decrease in blood eosinophil level, and the induction of focal necrosis with eosinophilic infiltration in the liver. The BN-derived allele of the marker gene on chromosome 1 was responsible for the decrease of both bone marrow and blood eosinophil levels. These data suggest the existence of genes characterizing/distinguishing the eosinophilic phenotypes of MES and BN.MES-Cyba mes on these chromosomes, and form the basis for positional cloning studies of the genes. These studies will advance the understanding of the mechanisms involved in eosinophil mobilization from the bone marrow and recruitment to the organs.

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Systemic and Eosinophilic Lesions in Rats with Spontaneous Eosinophilia (mesRats)

Cited by 13 publications

References 14 publications

Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyser

Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyser

A Third Locus for Eosinophilia on Chromosome 1 of the MES Rats

Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cybames Rats Are on Chromosomes 9, 5, and 1

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