Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyser

Muto, Shin-ichi; Kawakubo, Masatomo; Matsushita, Norifumi; Maeda, N.; Momose, Yasunori; Matsumoto, Kiyoshi

doi:10.1258/0023677052886556

Cited by 10 publications

(15 citation statements)

References 18 publications

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“…The hematological analysis of all groups showed that lymphocytes were predominant among the white blood cells, a natural finding in normal adult Sprague-Dawley rats (27).…”

Section: Discussionmentioning

confidence: 83%

Effect of FTY720 on Chronic Cyclosporine Nephropathy in Rats

Kim

Lim

et al. 2005

Transplantation

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“…The hematological analysis of all groups showed that lymphocytes were predominant among the white blood cells, a natural finding in normal adult Sprague-Dawley rats (27).…”

Section: Discussionmentioning

confidence: 83%

Effect of FTY720 on Chronic Cyclosporine Nephropathy in Rats

Kim

Lim

et al. 2005

Transplantation

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“…The Matsumoto Eosinophilia Shinshu (MES) rat strain has a genetic predisposition to develop eosinophilia [18,[20][21][22][23][24]34]. In these rats, a marked increase in peripheral blood eosinophils (>500/µl) occurs at about nine weeks of age, with eosinophilia progressing with age until the number of eosinophils eventually exceeds the level that is characteristic of human idiopathic hypereosinophilia (>1,500/µl).…”

Section: Introductionmentioning

confidence: 99%

Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cybames Rats Are on Chromosomes 9, 5, and 1

et al. 2011

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Abstract:The Matsumoto Eosinophilia Shinshu (MES) rat strain develops hereditary blood eosinophilia due to the mutant Cyba mes gene. In contrast, BN.MES-Cyba mes congenic rats, in which the mutant Cyba mes gene introduced into the background of the BN strain, have a normal blood eosinophil level despite showing robust proliferation of eosinophils in the bone marrow. However, the congenic rats manifest focal necrosis with eosinophilic infiltration in the liver, a phenotype rarely observed in the original MES rat strain. To elucidate the genetic basis for the strain differences, (MES × BN.MES-Cyba mes )F 2 rats were bred, and genetic analyses of phenotypes for eosinophilia were performed. Blood and bone marrow eosinophil levels in the F 2 rats showed broad distributions, suggesting that the traits were under the influence of multiple genes. Genetic association studies revealed that BN-derived marker loci on chromosomes 9 and 5 were responsible for the increase in eosinophil level in the bone marrow, decrease in blood eosinophil level, and the induction of focal necrosis with eosinophilic infiltration in the liver. The BN-derived allele of the marker gene on chromosome 1 was responsible for the decrease of both bone marrow and blood eosinophil levels. These data suggest the existence of genes characterizing/distinguishing the eosinophilic phenotypes of MES and BN.MES-Cyba mes on these chromosomes, and form the basis for positional cloning studies of the genes. These studies will advance the understanding of the mechanisms involved in eosinophil mobilization from the bone marrow and recruitment to the organs.

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“…The Matsumoto Eosinophilia Shinshu (MES) rat strain genetically develops eosinophilia [12,[16][17][18]23]. In these rats, a marked increase in peripheral blood eosinophils (>500/µl) occurs at about nine weeks of age, with eosinophilia progressing with age until the number of eosinophils eventually exceeds the level that is characteristic of human idiopathic hypereosinophilia (>1,500/ µl).…”

Section: Introductionmentioning

confidence: 99%

BN.MES-Cybames Congenic Rats Manifest Focal Necrosis with Eosinophilic Infiltration in the Liver without Blood Eosinophilia

et al. 2010

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Abstract:The Matsumoto Eosinophilia Shinshu (MES) rat strain develops hereditary blood eosinophilia and eosinophil-related inflammatory lesions in organs due to the mutant Cyba mes gene. We hypothesized that a new eosinophilia model with a different phenotype could be established by changing the genetic background of rats. We bred and characterized a congenic strain, in which the mutant Cyba mes gene was introduced into the background of a BN strain (BN.MES-Cyba mes ). The congenic rats showed robust proliferation of eosinophils in the bone marrow. Nonetheless, blood eosinophil levels of the rats remained within the normal range. In addition, the rats manifested focal necrosis with eosinophilic infiltration in the liver, a phenotype rarely observed in the original MES rat strain. These results imply the presence of genetic polymorphisms between MES and BN strains which modulate the mobilization of eosinophils to the peripheral circulation and organs. The newly established BN.MES-Cyba mes congenic rat strain, together with the original MES strain, will provide useful models for elucidating the molecular genetic mechanisms involved in the development and trafficking of eosinophils.

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Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyser

Cited by 10 publications

References 18 publications

Effect of FTY720 on Chronic Cyclosporine Nephropathy in Rats

Effect of FTY720 on Chronic Cyclosporine Nephropathy in Rats

Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cybames Rats Are on Chromosomes 9, 5, and 1

BN.MES-Cybames Congenic Rats Manifest Focal Necrosis with Eosinophilic Infiltration in the Liver without Blood Eosinophilia

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