Idiopathic Eosinophilic Masses of the Gastrointestinal Tract in Dogs

Lyles, Sarah E.; Panciera, David L.; Saunders, Geoffrey K.; Leib, Michael S.

doi:10.1111/j.1939-1676.2009.0343.x

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…Interestingly, in a descriptive study of cats with hepatic lipidosis only two of 60 cats had hypocholesterolaemia (Center et al 1993). A low cholesterol measurement has been observed to occur in 29-85% of dogs with protein-losing enteropathies (Littman et al 2000, Kull et al 2001, Lyles et al 2009. Congruent to our findings, liver disease was the most common disease associated with hypocholesterolaemia among hospitalised human medicine patients and also occurred in 31% of the study group (Oster et al 1981).…”

Section: Discussionsupporting

confidence: 74%

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Period prevalence and mortality rates associated with hypocholesterolaemia in dogs and cats: 1,375 cases

Tan

Epstein

Hopper

2020

J of Small Animal Practice

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To determine the period prevalence of hypocholesterolaemia and the associated mortality rates in dogs and cats at a university teaching hospital. The secondary aim was to identify disease processes associated with hypocholesterolaemia. Materials and MethOds: Medical records over a 5-year period were reviewed to determine the severity of hypocholesterolaemia and its associated mortality rate. Medical records of animals with moderate to severe hypocholesterolaemia (<2.59 mmol/L in dogs, <1.81 mmol/L in cats) were analysed further. Animals with hospital-acquired hypocholesterolaemia were identified. results: Among 16,977 dogs and 3,788 cats that had at least one cholesterol measurement, the period prevalence of hypocholesterolaemia was 7.0% in dogs and 4.7% in cats. The mortality rate of hypocholesteraemic dogs and cats was 12% in both species which was significantly higher than that of animals with normal serum cholesterol. The degree of hypocholesterolaemia was significantly associated with mortality. Dogs, but not cats, with hospital-acquired hypocholesterolaemia had a higher mortality rate than those presenting with hypocholesterolaemia. Disease of hepatic, gastrointestinal and lymphoreticular systems were most commonly associated with hypocholesterolaemia, and infectious and neoplastic disease were the most commonly associated pathophysiologic processes in both species. Lymphoma was over-represented in dogs with neoplasia. clinical significance: Hypocholesterolaemia is not a frequent abnormality but was associated with mortality in this study and may be a negative prognostic indicator. It is not known if hypocholesterolaemia is simply a marker for disease severity, or if it is has active physiologic effects contributing to poor outcomes.

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Section: Discussionsupporting

confidence: 74%

“…2001, Lyles et al . 2009). Congruent to our findings, liver disease was the most common disease associated with hypocholesterolaemia among hospitalised human medicine patients and also occurred in 31% of the study group (Oster et al .…”

Section: Discussionmentioning

confidence: 99%

Period prevalence and mortality rates associated with hypocholesterolaemia in dogs and cats: 1,375 cases

Tan

Epstein

Hopper

2020

J of Small Animal Practice

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“…5 In spite of the established importance of dyslipidem ias in morbidity and mortality in critically ill people, the prevalence, causes and consequences of hypocholes terolemia in veterinary medicine remain poorly char acterized. Low serum cholesterol has been commonly reported in dogs with hepatic (acute liver failure, porto systemic shunts), [6][7][8] gastrointestinal (chronic enteropa thies, proteinlosing enteropathies) [9][10][11][12] and inflammatory (eosinophilic intestinal granulomas, immunemediated anemia) diseases, 13,14 as well as some neoplasia (histio cytic sarcomas). 15 As a predictor of morbidity and mor tality, cholesterol levels have been shown to be lower in nonsurvivor populations of dogs suffering from heat shock, parvoviral enteritis, aflatoxicosis and sepsis.…”

Section: Introductionmentioning

confidence: 99%

Hypocholesterolemia in cats: a multicenter retrospective study of 106 cats

Bowman

Viall

Rudinsky

et al. 2019

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to describe the clinicopathologic findings and associated diseases found in a population of hypocholesterolemic cats referred to two tertiary care facilities. Methods An electronic medical record search was performed at two veterinary university referral centers to identify cats with serum cholesterol values below reference interval between January 2004 and 2016. Clinicopathologic data were reviewed for each case and cats were classified into specific disease categories based on clinical diagnosis. Median cholesterol values were compared between disease categories, as well as between survivors and non-survivors. Results In total, 106 hypocholesterolemic cats were included. The median age of the cats was 6 years (range 0.24–18 years). The most common disease categories were gastrointestinal (25.9%), hepatobiliary (19.8%), hematologic (14.8%) and urogenital (14.8%). Though median serum cholesterol values did not differ significantly between survivors and non-survivors, cats with concurrent hypoalbuminemia were at higher risk (odds ratio 15.6, 95% confidence interval 5.2–46.6; P <0.0001) of not surviving to discharge than cats with normal serum albumin concentrations. Conclusions and relevance Taken together, our data suggest that while the degree of hypocholesterolemia did not appear to influence survival rates, the concurrent presence of hypocholesterolemia and hypoalbuminemia was associated with a worse prognosis.

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“…The horizontal line represents the median. An outlier in the neoplasia group with 20.03 × 10 cells/L (Lyles et al., 2009) was removed to improve display…”

Section: Resultsmentioning

confidence: 99%

Peripheral blood eosinophilia in dogs: Prevalence and associated diseases

Guija-De-Arespacochaga

Kremer

Künzel

et al. 2022

Veterinary Medicine & Sci

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Background Canine eosinophilia has not been evaluated over the last two decades. As in human local differences, changes in the prevalence and associated diseases over time can be expected. Objective This study aims to determine the prevalence and causes of marked blood eosinophilia in dogs. Methods Retrospective study. A total of 317 clinical histories of dogs with an eosinophil concentration > 1.5 × 109/L (marked eosinophilia) between 2013 and 2017 were evaluated. Patients were allocated to 10 groups according to their major clinical findings. Results Eosinophilia was present in 1,592 of 10,829 dogs (14.7%); it was mild (0.8–1.49 × 109/L) in 78.4%, moderate (1.5 – 4.9 × 109/L) in 20.5% and severe (> 5 × 109/L) in 1.1% of cases. Rottweilers were overrepresented (16.1%). Of 317 cases with marked eosinophilia, 19.6% had neoplasia, 19.1% gastrointestinal disorders, 13.6% health check, 10.4% endoparasites, 6% respiratory, 5.4% neurologic, 5.4% dermatologic, 4.8% urogenital, 3.2% endocrine disorders and 12.6% miscellaneous. Lymphomas (29%) and mast cell tumours (12.9%) were the most frequent tumours in the neoplasia group. A total of 72.6% of tumour‐bearing dogs were older than 8 years, while 63.6% of dogs had endoparasites, and 86% of apparently healthy dogs were younger than 5 years. Eosinophilia was significantly higher in patients with respiratory disorders (p < 0.0146). Leukocytosis was found in 50.2% of cases. Conclusion Malignancy was the most common cause of marked blood eosinophilia in older dogs and endoparasitism in younger dogs. Eosinophilia was common in apparently healthy young dogs and may be related to undiagnosed parasitic infestations.

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Idiopathic Eosinophilic Masses of the Gastrointestinal Tract in Dogs

Cited by 12 publications

References 20 publications

Period prevalence and mortality rates associated with hypocholesterolaemia in dogs and cats: 1,375 cases

Period prevalence and mortality rates associated with hypocholesterolaemia in dogs and cats: 1,375 cases

Hypocholesterolemia in cats: a multicenter retrospective study of 106 cats

Peripheral blood eosinophilia in dogs: Prevalence and associated diseases

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