Eosinophil apoptosis in induced sputum from patients with seasonal allergic rhinitis and with asymptomatic and symptomatic asthma

Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis

“…IL5, IL18 blood levels, blood and sputum count of eosinophils have been shown to increase during pollen season and to parallel bronchial hyperresponsiveness (14,15,(18)(19)(20). Given these observations, the stability of proinflammatory cytokines during and outside the pollen season in our study are consistent with the absence of cypress pollen induced bronchial hyperresponsiveness in the majority of patients.…”

“…The large majority of these studies are addressing grass pollen allergy (15,(18)(19)(20) and evidence of this finding is lacking in cypress pollen allergy. Allergic rhinitis and asthma are airways diseases that often occur concomitantly.…”

Reduced eosinophil apoptosis in induced sputum correlates with asthma severity

“…Examination of induced sputum using nebulised hypertonic saline is a well-validated noninvasive procedure for the assessment of airway inflammation in asthma [5][6][7][8]. However, to date there have been few studies that have utilised this technique to compare the relationship between measures of eosinophil apoptosis or survival in induced sputum with clinical and functional parameters of disease severity [5][6][7][8][9][10].…”

“…However, to date there have been few studies that have utilised this technique to compare the relationship between measures of eosinophil apoptosis or survival in induced sputum with clinical and functional parameters of disease severity [5][6][7][8][9][10]. The authors hypothesised that there is a relationship between reduced eosinophil apoptosis and both a global clinical severity score and separate components of the asthma phenotype.…”

Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis

“…It is conceivable that chronic mucosa inflammation in nasal tissue plays an important role in the recurrent attacks of allergic rhinitis (Foresi et al, 2000). The major infiltrated cells in the nasal mucosa of patients with allergic rhinitis (AR) include eosinophils and neutrophils (Savill, 1997;Hans-Uwe, 1999).…”