Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis

Pahus, Laurie; Gouitaa, M.; Sofalvi, T.; Alagha, Khuder; Gras, Delphine; Chanez, Pascal; Charpin, D.

doi:10.23822/eurannaci.1764-1489.34

Cited by 7 publications

(4 citation statements)

References 24 publications

(39 reference statements)

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“…An exception to this rule was observed in Marseille, where many patients also reported moderate to severe symptoms although mono‐sensitized to cypress pollen. This may indicate a more severe clinical phenotype of cypress pollen allergy, also suggested by a younger age at disease onset (average 10 years) than observed in a previous local study 25 . Second, the frequency of comorbidities was also highly heterogeneous among study centers.…”

Section: Discussionmentioning

confidence: 71%

“…This may indicate a more severe clinical phenotype of cypress pollen allergy, also suggested by a younger age at disease onset (average 10 years) than observed in a previous local study. 25 Second, the frequency of comorbidities was also highly heterogeneous among study centers. The highest number of comorbidities per patient was observed in Rome, which was also the center with the highest degree of poly-sensitization.…”

Section: Discussionmentioning

confidence: 99%

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Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study

Dramburg,

Grittner,

Potapova

et al. 2024

Allergy

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BackgroundPollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central and Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern European countries with a standardized approach.ObjectiveTo describe sensitization profiles and clinical phenotypes of pollen allergic patients in nine Southern European cities with a uniform methodological approach.MethodsWithin the @IT.2020 multicenter observational study, pediatric and adult patients suffering from SAR were recruited in nine urban study centers located in seven countries. Clinical questionnaires, skin prick tests (SPT) and specific IgE (sIgE) tests with a customized multiplex assay (Euroimmun Labordiagnostika, Lübeck, Germany) were performed.ResultsThree hundred forty‐eight children (mean age 13.1 years, SD: 2.4 years) and 467 adults (mean age 35.7 years SD: 10.0 years) with a predominantly moderate to severe, persistent phenotype of SAR were recruited. Grass pollen major allergenic molecules (Phl p 1 and/or Phl p 5) ranged among the top three sensitizers in all study centers. Sensitization profiles were very heterogeneous, considering that patients in Rome were highly poly‐sensitized (sIgE to 3.8 major allergenic molecules per patient), while mono‐sensitization was prominent and heterogeneous in other cities, such as Marseille (sIgE to Cup a 1: n = 55/80, 68.8%) and Messina (sIgE to Par j 2: n = 47/82, 57.3%). Co‐sensitization to perennial allergens, as well as allergic comorbidities also broadly varied between study centers.ConclusionsIn Southern European countries, pollen allergy is heterogeneous in terms of sensitization profiles and clinical manifestations. Despite the complexity, a unique molecular, multiplex, and customized in‐vitro IgE test detected relevant sensitization in all study centers. Nevertheless, this geographical diversity in pollen allergic patients imposes localized clinical guidelines and study protocols for clinical trials of SAR in this climatically complex region.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study

Dramburg,

Grittner,

Potapova

et al. 2024

Allergy

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“…Leila et al found higher habitual snoring frequencies among children residing in neighborhoods with the highest pollution levels showed an inverse relationship between ambient air quality and snoring in school-aged children [ 27 ]. Particulate matter (PM 2.5 and PM 10 ) and pollen can penetrate deep into human lungs, resulting in biological changes in the respiratory system, including the induction of inflammatory reactions, oxidative stress, and DNA damage, which could exacerbate the symptoms of respiratory diseases such as asthma, sleep apnea, and rhinitis [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Does seasonality affect snoring? A study based on international data from the past decade

Wang

Zhang

et al. 2022

Sleep Breath

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Background Though snoring is often regarded as a harmless condition that coincides with sound sleep, it is a sleep disorder that can be a potential indicator of more severe conditions such as sleep apnea syndrome. In the present study, we investigated the association between seasonal variations and snoring. Method Search index for snoring (SIS) data were obtained from Google Trends and Baidu Index. SIS data were collected for the USA, India, Germany, Russia, Japan, Australia, China, and Brazil from 2011 to 2020, with the periodicity of the relationship between seasonal time series data and snoring evaluated using a time series decomposition model. Result The highest average SIS growth rates from 2011 to 2020 were observed for Brazil, Japan, and Germany, with average SIS values of 94%, 68%, and 49%, respectively. The SIS of the USA, Russia, Japan, Brazil, Australia, Germany, and India increased by 22.3%, 12.4%, 11.9%, 35.4%, 12.3%, 28.0%, and 55.8%, respectively, in comparison with their SIS values in 2019, whereas for China, it decreased by 13.7%. Relative to countries in the southern hemisphere, those in the northern hemisphere showed comparable SIS trends, increasing from September to February and decreasing from March to August. Conclusion The SIS data showed cyclical changes over the study period. The search index for snoring increased during the cold season or the heating season, suggesting that snoring is associated with seasonal changes.

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“…L'allergie aux GRP se manifeste habituellement par un syndrome oral lors de l'ingestion du fruit incriminé (en été) avec prurit et angio-oedème, en plus des symptômes provoqués par l'inhalation du pollen de cyprès (en hiver) qui comprennent en plus de la rhinite, une toux sèche associée à une hyperréactivité bronchique chez un tiers des patients environ [39]. Des cofacteurs tels que l'activité physique ou la prise d'anti-inflammatoire non stéroïdien peuvent aggraver les symptômes jusqu'au choc anaphylactique [40,41].…”

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Syndrome allergique pollen-fruit : actualités sur les allergènes impliqués

Couderc

Sénéchal

Aizawa

et al. 2021

Bulletin de l'Académie Nationale de Médecine

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Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis

Abstract: Summary

Cited by 7 publications

References 24 publications

Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study

Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study

Does seasonality affect snoring? A study based on international data from the past decade

Syndrome allergique pollen-fruit : actualités sur les allergènes impliqués

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