Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis

Yang, Sien-Hung; Yu, Chia‐Li

doi:10.1016/j.jep.2007.09.011

Cited by 54 publications

(51 citation statements)

References 20 publications

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“…Of interest, one of the regulators of the STAT pathway is the suppressor of cytokine signaling family (SOCS), and the SOCS3 enzyme has been implicated in the propagation of allergic responses with increased expression of SOCS3, resulting in greater T H 2 differentiation. [105][106][107] A final biochemical pathway for the JAK/STAT pathway includes the GATA transcription family. Activation of STAT6 leads to expression of GATA-3, which in turn will transform naive CD4 1 T cells into the T H 2 subtype.…”

Section: Magnololmentioning

confidence: 99%

Complementary and alternative medicine: Herbs, phytochemicals and vitamins and their immunologic effects

Mainardi¹,

Kapoor²,

Bielory³

2009

Journal of Allergy and Clinical Immunology

180

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Section: Magnololmentioning

confidence: 99%

Complementary and alternative medicine: Herbs, phytochemicals and vitamins and their immunologic effects

Mainardi¹,

Kapoor²,

Bielory³

2009

Journal of Allergy and Clinical Immunology

180

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“…In contrast, our previous studies have demonstrated that a mixed herbal formula consisting of Xin-yi-san, Xiao-gin-long-tang, and Xiang-sha-liu-jun-zi-tang exhibited beneficial effects in treatment of perennial allergic rhinitis through modulating the functions of lymphocytes and neutrophils [5,6]. In addition, we have found that Bu-zhong-yi-qi-tang exerted anti-inflammatory activities that suppressed nasal inflammation in patients with perennial allergic rhinitis in non-acute stage [16].…”

Section: Discussionmentioning

confidence: 67%

Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects

Yang

Chen

et al. 2010

International Immunopharmacology

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“…Some investigators reported that Agastache rugosa contains volatile components (Kim et al, 2001) possess antimycotic properties (Blaszczyk et al, 2000;Shin and Kang, 2003) as well as antioxidant (Oh et al, 2006) and free radical scavenging activities (Wang et al, 2006) in vitro. Further, Atractylodes lancea and Cortex Phellodendri have antioxidant and anti-inflammatory properties (Cai et al, 2004;Kong et al, 2004;Che et al, 2005;Yang and Yu, 2008). The essential oil of Atractylodes lancea has effects on gastric motor dysfunction induced by mental stress (Nakai et al, 2003;Zhang et al, 2008) and its extract can modulate the function of the intestinal immune system (Yu et al, 2001;Taguchi et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Taguchi approach for anti-heat stress prescription compatibility in mice spleen lymphocytes In Vitro

Zhu

Cheng

et al. 2011

Arch. Pharm. Res.

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Heat stress (HS) may induce immunosuppression as well as inhibit the proliferation of lymphocytes. This study evaluated the effects on immune function of our prescription on splenic lymphocytes under HS as well as its compatibility. The effects of four herbal extracts from Agastache rugosa, Atractylodes lancea, Cortex Phellodendri, and Gypsum Fibrosum on heat treated splenic lymphocytes were investigated and the compatibility of the prescription was also explored by using the Taguchi method. This study revealed changes in proliferation by traditional Chinese medicines of splenic lymphocytes after HS. Proliferation in the HS group was significantly lower than the control group. Under HS, the effects of higher concentrations of Agastache rugosa (100 and 200 μg/mL), Atractylodes lancea (100 and 200 μg/mL), Cortex Phellodendri (50 and 100 μg/mL) and Gypsum Fibrosum (100 and 200 μg/mL) caused a significant increase on ConA/LPS-induced proliferation of lymphocytes than lower concentrations. We, therefore, conclude that the prescription of traditional Chinese medicines may recover splenic lymphocytes from the immunosuppression induced by HS. The Taguchi design, which allows rapid and high efficiency for the selection of the best conditions for our prescription on HS-treated splenic lymphocytes, demonstrated that Agastache rugosa (200 μg/mL), Atractylodes lancea (200 μg/mL), Cortex Phellodendri (100 μg/mL) and Gypsum Fibrosum (100 μg/mL) were the optimal conditions for the prescription. The validation experiment confirmed that our composition in optimum extraction conditions enhanced effects on ConA or LPS-stimulated lymphocytes under HS. The results showed that the Taguchi optimization approach is a suitable method for optimization of the composition of prescription.

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Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis

Cited by 54 publications

References 20 publications

Complementary and alternative medicine: Herbs, phytochemicals and vitamins and their immunologic effects

Complementary and alternative medicine: Herbs, phytochemicals and vitamins and their immunologic effects

Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects

Taguchi approach for anti-heat stress prescription compatibility in mice spleen lymphocytes In Vitro

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