Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta

Henderson, Neil; Stear, M. J.

doi:10.1016/j.vetimm.2006.03.012

Cited by 76 publications

(97 citation statements)

References 16 publications

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“…Most of the IgA, the isotype closely associated with intestinal mucosal immune responses, in sheep blood derives from the mucosal surface of the gastrointestinal tract (Sheldrake et al, 1984), and blood and mucosal IgA levels are correlated (Henderson and Stear, 2006;Martínez-Valladares et al, 2005). IgA produced in the gastrointestinal tract can either bind to parasites and parasite secretions, or be transferred to the blood via the lymphatic system.…”

Section: Discussionmentioning

confidence: 99%

Response to Teladorsagia circumcincta infection in Scottish Blackface lambs with divergent phenotypes for nematode resistance

McRae

Good

Hanrahan

et al. 2014

Veterinary Parasitology

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The objective of this study was to identify Scottish Blackface lambs that were at the extremes of the spectrum of resistance to gastrointestinal nematodes and characterise their response to an experimental nematode challenge. Lambs (n = 90) were monitored for faecal egg count (FEC) (2 samples from each of 2 independent natural infections). The most resistant (n = 10) and susceptible (n = 10) individuals were selected and challenged with 30,000 Teladorsagia circumcincta larvae (L3) at 9 months of age. Response to infection was monitored by measuring FEC, plasma pepsinogen, serum antibodies against nematode larval antigens and haematology profile, until necropsy at 71 days post infection. Worm burden, worm fecundity and the level of anti-nematode antibodies in abomasal mucosa were determined at necropsy.FEC was consistently higher in susceptible animals (P < 0.05), validating the selection method. Worm fecundity was significantly reduced in resistant animals (P = 0.03). There was also a significant correlation (r = 0.88; P < 0.001) between the number of adult worms and FEC at slaughter. There was no effect of phenotype (resistance/susceptibility) on plasma pepsinogen or on haematology profile.Phenotype had a significant effect on the level of anti-nematode IgA antibodies in serum (P < 0.01), reflecting a higher peak in resistant animals at day 7 post infection.It is concluded that significant variation in the response to gastrointestinal nematode challenge exists within the Scottish Blackface population with resistant animals displaying significantly lower FEC, lower worm fecundity and higher concentration of anti-nematode IgA antibodies in serum.-4 -

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Section: Discussionmentioning

confidence: 99%

Response to Teladorsagia circumcincta infection in Scottish Blackface lambs with divergent phenotypes for nematode resistance

McRae

Good

Hanrahan

et al. 2014

Veterinary Parasitology

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“…Increased production of specifi c IgA after infection is also an indicator of immune responsiveness according to the response to H. contortus (Amarante et al, 2005) and T. circumcinta (Martínez-Valladares et al, 2005;Henderson et al, 2006). Plasma IgA titres in early weaned ewes increased, becoming significantly higher to those measured in suckled ewes (Beasley et al, 2010).…”

Section: Haemonchus Contortus Antigenmentioning

confidence: 99%

“…According to Henderson et al (2006) and Macarthur et al (2013), evidence exists for a general immune response of the peri-parturient ewe beginning on day -29, as measured by a low number of eosinophil cells. In contrast, antibody titres in gut tissue of infected ewes remain elevated (Houdijk et al, 2005).…”

Section: Haemonchus Contortus Antigenmentioning

confidence: 99%

Immune and haematological parameters of Blackbelly ewes infected with gastrointestinal nematodes

González-Gardúño

Arellano

Felipe

et al. 2017

Rev Colomb Cienc Pecu

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“…However, their protective role against T. circumcincta is unclear. Henderson and Stear (2006) found no relationship between numbers of adult T. circumcincta and tissue eosinophilia. At the same aspect, Beraldi et al (2008) did not observe relationship between FEC and circulating eosinophil counts.…”

Section: The Role Of Immunoglobulin a (Iga) And Immunoglobulin E (Ige)mentioning

confidence: 69%

Immune and other factors modulating host resistance against gastrointestinal nematode parasites in sheep

Arsenopoulos

Symeonidou

Papadopoulos

2018

J Hellenic Vet Med Soc

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Infection of small ruminants with gastrointestinal nematode (GIN) parasites is a significant problem with crucial impact on meat and milk production. The strategy of administrating anthelminthic drugs has been implemented for many years and has resulted in the development of resistant strains of parasites. Meanwhile, consumers demand for free of drugs products have led to the adoption of alternative control methods, which involve the selective breeding of animals, which are resistant to parasitism. The development of immunity and therefore, resistance against gastrointestinal parasites is based on the activation of specific host genes. Gene analysis has revealed areas (QTLs), which affect resistance or susceptibility of sheep to gastrointestinal infestations between animals of different breeds and between individuals of the same breed. The role of cytokines and T helper cells has been enhanced as research, strongly, supports the connection of Th2 cells with resistance and Th1 cells with susceptibility against GIN. Latest data implicates T regulatory cells and a specific cell type, Th17, in immune response mechanisms. Specific adhesion molecules (integrins, lectins, cadherins) are produced in the gut lumen in sufficient amounts and appear to boost immunity and reduce clinical signs in sheep. Additionally, the immunoglobulins IgA and IgE have been positively correlated with increased resistance against GIN. In several cases of GIN, where an increased number of eosinophils and mast cells in the intestinal epithelium have been recorded, the animals had a reduced number of parasite eggs in their feces. The genes of the Major Histocompatibility Complex have been referred to as potential resistance or susceptibility markers. Other enzymes, like chitinases, enhance the resilience of animals and protect them effectively. Animal’s nutritional status is another determinant factor of immune capability against GIN in sheep, both systemic, as well as locally. Regarding the effect of reactive oxygen and nitrogen species, some researchers support their direct effect against GIN, resulting in a natural reduction of their number, while others claim the indirect action in the intestinal epithelium by reducing local immunity. Consequently, the detection of genes associated with resistance or susceptibility to gastrointestinal infestations is promising and in line with modern requirements.

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Eosinophil and IgA responses in sheep infected with Teladorsagia circumcincta

Cited by 76 publications

References 16 publications

Response to Teladorsagia circumcincta infection in Scottish Blackface lambs with divergent phenotypes for nematode resistance

Response to Teladorsagia circumcincta infection in Scottish Blackface lambs with divergent phenotypes for nematode resistance

Immune and haematological parameters of Blackbelly ewes infected with gastrointestinal nematodes

Immune and other factors modulating host resistance against gastrointestinal nematode parasites in sheep

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