Enzyme Secretion and the Incorporation of P32 Into Phospholipides of Pancreas Slices

Hokin, Mabel R.; Hokin, Lowell E.

doi:10.1111/j.1753-4887.1989.tb02827.x

Cited by 69 publications

(78 citation statements)

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“…In his influential review, Bob Michell (Michell 1975), building on work showing that many of these receptors also stimulate phospholipid turnover (Hokin and Hokin 1953), had suggested a causal link between phosphoinositide hydrolysis and Ca 2þ signals. Here, as in many studies, the emphasis was on Ca 2þ entry, with a consensus only slowly emerging that Ca 2þ fluxes across both the plasma membrane and the membranes of intracellular stores contribute to cytosolic Ca 2þ signals (Rasmussen 1970;Berridge 1975;Williams 1980;Putney et al 1981).…”

mentioning

confidence: 99%

IP3 Receptors: Toward Understanding Their Activation

Taylor¹,

Tovey²

2010

Cold Spring Harbor Perspectives in Biology

257

190

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Inositol 1,4,5-trisphosphate receptors (IP 3 R) and their relatives, ryanodine receptors, are the channels that most often mediate Ca 2þ release from intracellular stores. Their regulation by Ca 2þ allows them also to propagate cytosolic Ca 2þ signals regeneratively. This brief review addresses the structural basis of IP 3 R activation by IP 3 and Ca 2þ . IP 3 initiates IP 3 R activation by promoting Ca 2þ binding to a stimulatory Ca 2þ -binding site, the identity of which is unresolved. We suggest that interactions of critical phosphate groups in IP 3 with opposite sides of the clam-like IP 3 -binding core cause it to close and propagate a conformational change toward the pore via the adjacent N-terminal suppressor domain. The pore, assembled from the last pair of transmembrane domains and the intervening pore loop from each of the four IP 3 R subunits, forms a structure in which a luminal selectivity filter and a gate at the cytosolic end of the pore control cation fluxes through the IP 3 R.

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mentioning

confidence: 99%

IP3 Receptors: Toward Understanding Their Activation

Taylor¹,

Tovey²

2010

Cold Spring Harbor Perspectives in Biology

257

190

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“…On the other hand, studies on signal transduction in animal cells have been popular since the 1980s according to the fundamental work of Berridge (1984) and of Nishizuka (1992), who discovered PKC (Takai et al, 1977) and developed PKC research in the signal transduction, being affected by the classic work of Hokin and Hokin (1953). Similar signal transduction pathways were reviewed in yeast cells (Thevelein, 1994).…”

Section: Discussionmentioning

confidence: 90%

Unique profiles of changes in cell membrane fluidity during ethanol-induced yeast-to-pseudohyphal transition in Candida tropicalis

Suzuki

Kono

Tawara

et al. 2010

J. Gen. Appl. Microbiol.

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“…The role of PI in signal transduction was first described in 1953 [8] . Signals involved in processes such as differentiation, proliferation, and apoptosis induce changes in inositol metabolism.…”

Section: Pi Signal Transduction Systemmentioning

confidence: 99%

“…Once activated by a wide array of stimuli, PI-PLC cleaves PIP2 into inositol trisphosphate (IP3) and diacylglycerol (DAG) in less than a second, both being crucial molecules in signal transduction [8] .…”

Section: Functionsmentioning

confidence: 99%

Phosphoinositide pathway and the signal transduction network in neural development

Vasco

2012

Neurosci. Bull.

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Abstract:The development of the nervous system is under the strict control of a number of signal transduction pathways, often interconnected. Among them, the phosphoinositide (PI) pathway and the related phospholipase C (PI-PLC) family of enzymes have been attracting much attention. Besides their well-known role in the regulation of intracellular calcium levels, PI-PLC enzymes interact with a number of molecules belonging to further signal transduction pathways, contributing to a specific and complex network in the developing nervous system. In this review, the connections of PI signalling with further transduction pathways acting during neural development are discussed, with special regard to the role of the PI-PLC family of enzymes.

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Enzyme Secretion and the Incorporation of P32 Into Phospholipides of Pancreas Slices

Cited by 69 publications

References 0 publications

IP3 Receptors: Toward Understanding Their Activation

IP3 Receptors: Toward Understanding Their Activation

Unique profiles of changes in cell membrane fluidity during ethanol-induced yeast-to-pseudohyphal transition in Candida tropicalis

Phosphoinositide pathway and the signal transduction network in neural development

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