IP3 Receptors: Toward Understanding Their Activation

Taylor, Colin W.; Tovey, Stephen C.

doi:10.1101/cshperspect.a004010

Cited by 250 publications

(185 citation statements)

References 248 publications

(277 reference statements)

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“…Each subunit has a mushroomlike structure; the larger dome (which includes the COOH and NH 2 termini and comprises ϳ85% of the protein) projects into the cytoplasm while the stalk corresponds to a transmembrane domain and luminal loop associated with the ER (364). The cytoplasmic domain contains an IP 3 binding site and a regulatory/coupling region (118).…”

Section: Ip 3 Rsmentioning

confidence: 99%

Intercellular Ca²⁺Waves: Mechanisms and Function

Leybaert

Sanderson

2012

Physiological Reviews

262

270

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Intercellular calcium (Ca 2ϩ ) waves (ICWs) represent the propagation of increases in intracellular Ca 2ϩ through a syncytium of cells and appear to be a fundamental mechanism for coordinating multicellular responses. ICWs occur in a wide diversity of cells and have been extensively studied in vitro. More recent studies focus on ICWs in vivo. ICWs are triggered by a variety of stimuli and involve the release of Ca 2ϩ from internal stores. The propagation of ICWs predominately involves cell communication with internal messengers moving via gap junctions or extracellular messengers mediating paracrine signaling. ICWs appear to be important in both normal physiology as well as pathophysiological processes in a variety of organs and tissues including brain, liver, retina, cochlea, and vascular tissue. We review here the mechanisms of initiation and propagation of ICWs, the key intra-and extracellular messengers (inositol 1,4,5-trisphosphate and ATP) mediating ICWs, and the proposed physiological functions of ICWs.

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Section: Ip 3 Rsmentioning

confidence: 99%

Intercellular Ca²⁺Waves: Mechanisms and Function

Leybaert

Sanderson

2012

Physiological Reviews

262

270

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“…Each monomer consists of more than 2600 amino acids and can be broadly divided into three regions, a cytosolic amino-terminal domain that binds IP 3 , a regulatory domain that contains multiple regulatory sites for Ca 2þ , ATP, and other modulatory molecules/ proteins (MacKrill 1999;Patterson et al 2004) and a carboxy-terminal channel domain that contains six transmembrane domains and a short cytosolic tail. As described by Taylor and Tovey (2010) (Taylor and Tovey 2010;Iino 1990;Finch et al 1991). This dual regulation of IP 3 R1 by Ca 2þ and IP 3 makes it especially suited to support long lasting oscillations.…”

Section: Ip 3 R1 In MII Eggsmentioning

confidence: 99%

Ca2+ Signaling During Mammalian Fertilization: Requirements, Players, and Adaptations

Wakai¹,

Vanderheyden²,

Fissore³

2011

Cold Spring Harbor Perspectives in Biology

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Changes in the intracellular concentration of calcium ([Ca 2þ ] i ) represent a vital signaling mechanism enabling communication among cells and between cells and the environment. The initiation of embryo development depends on a [Ca 2þ ] i increase(s) in the egg, which is generally induced during fertilization. The [Ca 2þ ] i increase signals egg activation, which is the first stage in embryo development, and that consist of biochemical and structural changes that transform eggs into zygotes. The spatiotemporal patterns of [Ca 2þ ] i at fertilization show variability, most likely reflecting adaptations to fertilizing conditions and to the duration of embryonic cell cycles. In mammals, the focus of this review, the fertilization [Ca 2þ ] i signal displays unique properties in that it is initiated after gamete fusion by release of a sperm-derived factor and by periodic and extended [Ca 2þ ] i responses. Here, we will discuss the events of egg activation regulated by increases in [Ca 2þ ] i , the possible downstream targets that effect these egg activation events, and the property and identity of molecules both in sperm and eggs that underpin the initiation and persistence of the [Ca 2þ ] i responses in these species.A n increase in the intracellular concentration of calcium ([Ca 2þ ] i ) underlies the initiation, progression and/or completion of a wide variety of cellular processes, including fertilization, muscle contraction, secretion, cell division, and apoptosis (Berridge et al. 2000). To survive and proliferate, cells and organisms must communicate, and changes in [Ca 2þ ] i allow them to quickly respond to environmental, nutritional, or ligand challenges with responses that regulate cell fate and function. Cells devote significant amounts of their energy reserves to create and maintain ionic gradients between extracellular and intracellular milieus and also within the latter, thereby allowing brief alterations in these gradients to have profound signaling effects. In the case of Ca 2þ , myriad proteins have acquired the ability to bind Ca 2þ , which allows them to interpret and transform these elevations into cellular functions. This review will examine the cellular modifications induced by [Ca 2þ ] i changes during fertilization in mature mammalian oocytes, henceforth referred to as eggs.Oocytes during maturation ready themselves for fertilization and the initiation of embryogenesis. During this transition, oocytes undergo changes that include the resumption and progression of meiosis, the development of polyspermy-preventing mechanisms, the reorganization of the cytoskeleton with spindle formation and displacement to the cortex, and the translation, accumulation, and degradation of specific mRNAs and proteins involved in development (Horner and Wolfner 2008b (Stricker 1999;Miyazaki and Ito 2006). Elucidation of the signaling cascades and identification of the molecules/receptor(s) that initiate the Ca 2þ signal at fertilization has proven elusive, and this review will not dwell on th...

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“…Inositol (1,4,5)-trisphosphate (IP 3 ), by stimulating Ca 2+ release from the endoplasmic reticulum (ER), provides a common link between receptors at the plasma membrane and cytoplasmic Ca 2+ signals. Diverse stimuli, via their receptors, stimulate phospholipase C (PLC) and so formation of IP 3 , which binds to IP 3 receptors (IP 3 R) causing Ca 2+ to leak into the cytosol (Foskett et al, 2007;Taylor and Tovey, 2010).…”

Section: Introductionmentioning

confidence: 99%

Cyclic AMP directs IP3-evoked Ca2+ signalling to different intracellular Ca2+ stores

Tovey

Taylor

2013

Journal of Cell Science

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SummaryCholesterol depletion reversibly abolishes carbachol-evoked Ca 2+ release from inositol (1,4,5)-trisphosphate (IP 3 )-sensitive stores, without affecting the distribution of IP 3 receptors (IP 3 R) or endoplasmic reticulum, IP 3 formation or responses to photolysis of caged IP 3 . Receptors that stimulate cAMP formation do not alone evoke Ca 2+ signals, but they potentiate those evoked by carbachol. We show that these potentiated signals are entirely unaffected by cholesterol depletion and that, within individual cells, different IP 3 -sensitive Ca 2+ stores are released by carbachol alone and by carbachol combined with receptors that stimulate cAMP formation. We suggest that muscarinic acetylcholine receptors in lipid rafts deliver IP 3 at high concentration to associated IP 3 R, stimulating them to release Ca 2+ . Muscarinic receptors outside rafts are less closely associated with IP 3 R and provide insufficient local IP 3 to activate IP 3 R directly. These IP 3 R, probably type 2 IP 3 R within a discrete Ca 2+ store, are activated only when their sensitivity is increased by cAMP. Sensitization of IP 3 R by cAMP extends the effective range of signalling by phospholipase C, allowing muscarinic receptors that are otherwise ineffective to recruit additional IP 3 -sensitive Ca 2+ stores.

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IP3 Receptors: Toward Understanding Their Activation

Cited by 250 publications

References 248 publications

Intercellular Ca²⁺Waves: Mechanisms and Function

Intercellular Ca²⁺Waves: Mechanisms and Function

Ca2+ Signaling During Mammalian Fertilization: Requirements, Players, and Adaptations

Cyclic AMP directs IP3-evoked Ca2+ signalling to different intracellular Ca2+ stores

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IP3 Receptors: Toward Understanding Their Activation

Cited by 250 publications

References 248 publications

Intercellular Ca2+Waves: Mechanisms and Function

Intercellular Ca2+Waves: Mechanisms and Function

Ca2+ Signaling During Mammalian Fertilization: Requirements, Players, and Adaptations

Cyclic AMP directs IP3-evoked Ca2+ signalling to different intracellular Ca2+ stores

Contact Info

Product

Resources

About

Intercellular Ca²⁺Waves: Mechanisms and Function

Intercellular Ca²⁺Waves: Mechanisms and Function