Phosphoinositide pathway and the signal transduction network in neural development

Vasco, Vincenza Rita Lo

doi:10.1007/s12264-012-1283-x

Cited by 28 publications

(17 citation statements)

References 106 publications

(153 reference statements)

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“…Cholinergic nerve stimulation in basal forebrain and hippocampus was reported to be excitotoxic, causing tonic-clonic convulsions due to the release of glutamate mediated through the production of ROS (reactive oxygen species) [7]. The brain and nervous system are considered to be more susceptible to peroxidative damage than other tissues due to their high content of polyunsaturated lipid, high oxygen utilization and low antioxidative enzymes [8].…”

Section: Introductionmentioning

confidence: 99%

Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats

et al. 2014

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Alzheimer's disease (AD) is a progressive neurological disorder that mostly affects the elderly population. Learning and memory impairment as the most characteristic manifestation of dementia could be induced chemically by scopolamine, a cholinergic antagonist. Cholinergic neurotransmission mediated brain oxidative stress. Citrus aurantium (CA) has traditionally been used for the treatment of insomnia, anxiety and epilepsy. The present study was designed to investigate the effect of Citrus aurantium on scopolamine-induced learning and memory deficit in rats. Forty-two Wistar rats were divided into six equal groups. (1) Control (received saline), (2) SCOP (scopolamine at a dose of 1 mg/kg for 15 days), (3) and (4) SCOP + CA (scopolamine and CA extract at doses of 300 and 600 mg/kg per day for 15 days), (5) and (6) intact groups (CA extract at 300 and 600 mg/kg per day for 15 days, respectively). Administration of CA flower extract significantly restored memory and learning impairments induced by scopolamine in the passive avoidance test and also reduced escape latency during trial sessions in the Morris water maze test. Citrus aurantium flower extract significantly decreased the serum malondialdehyde (MDA) levels. Citrus aurantium flower extract has repairing effects on memory and behavioral disorders produced by scopolamine and may have beneficial effects in the treatment of AD.

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Section: Introductionmentioning

confidence: 99%

Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats

et al. 2014

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“…Several Notch signaling pathway studies on neuronal development and neuronal degeneration have been reported [ 39 ]. The phosphatidylinositol signaling pathway is important in intra- and extra-cellular signaling and affects neuron development [ 40 ]. TOR signaling has also been reported as a key molecular pathway in nervous system development [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Functional enrichment analysis based on long noncoding RNA associations

et al. 2018

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BackgroundDifferential gene expression analysis using RNA-seq data is a popular approach for discovering specific regulation mechanisms under certain environmental settings. Both gene ontology (GO) and KEGG pathway enrichment analysis are major processes for investigating gene groups that participate in common biological responses or possess related functions. However, traditional approaches based on differentially expressed genes only detect a few significant GO terms and pathways, which are frequently insufficient to explain all-inclusive gene regulation mechanisms.MethodsTranscriptomes of survivin (birc5) gene knock-down experimental and wild-type control zebrafish embryos were sequenced and assembled, and a differential expression (DE) gene list was obtained for traditional functional enrichment analysis. In addition to including DE genes with significant fold-change levels, we considered additional associated genes near or overlapped with differentially expressed long noncoding RNAs (DE lncRNAs), which may directly or indirectly activate or inhibit target genes and play important roles in regulation networks. Both the original DE gene list and the additional DE lncRNA-associated genes were combined to perform a comprehensive overrepresentation analysis.ResultsIn this study, a total of 638 DE genes and 616 DE lncRNA-associated genes (lncGenes) were leveraged simultaneously in searching for significant GO terms and KEGG pathways. Compared to the traditional approach of only using a differential expression gene list, the proposed method of employing DE lncRNA-associated genes identified several additional important GO terms and KEGG pathways. In GO enrichment analysis, 60% more GO terms were obtained, and several neuron development functional terms were retrieved as complete annotations. We also observed that additional important pathways such as the FoxO and MAPK signaling pathways were retrieved, which were shown in previous reports to play important roles in apoptosis and neuron development functions regulated by the survivin gene.ConclusionsWe demonstrated that incorporating genes near or overlapped with DE lncRNAs into the DE gene list outperformed the traditional enrichment analysis method for effective biological functional interpretations. These hidden interactions between lncRNAs and target genes could facilitate more comprehensive analyses.

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“…This increase of Ca 2+ moves PKC to translocate from cytoplasm to the cytoplasmic face of the plasma membrane [91]. Activated PKC enzymes phosphorylate specific serine or threonine residues on target proteins [91,96].…”

Section: Figurementioning

confidence: 99%

Insights into Brain Signal Transduction can Provide Potential Molecular Targets to Approach and Manage Alzheimer’s Disease

Vasco¹,

Rita²

2020

OBM Neurobiology

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Mechanisms leading to neuronal cell death in human pathology are far from being fully delineated. Understanding the molecules involved in neuronal death and the timing of their recruitment might help to explain the natural history of degenerative processes, including the morphological abnormalities observed in Alzheimer's disease (AD). Moreover, it might help refine the diagnosis by defining new molecular markers as well as find effective therapies, especially for slow cognitive deficits, often associated with neurodegenerative diseases. Disturbances in signal transduction in neurons underlie human cognitive decline. Numerous studies have analyzed the different signal transduction pathways in AD, offering interesting insights into its etiology and prospective therapies. For example, studies revealed that AD is associated with abnormal neuronal Ca 2+ homeostasis, and that signal transduction pathways are involved in Ca 2+ metabolism and phosphorylative regulation of proteins. Understanding the role and timing of action of the signaling pathways recruited during the changes in brain morphology in AD progression might help elucidate the pathogenesis of the disease, paving the way for early diagnosis, prognosis refinement, and novel molecular therapeutic strategies. In this review, we discuss the different signal transduction pathways involved in AD pathogenesis.

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Phosphoinositide pathway and the signal transduction network in neural development

Cited by 28 publications

References 106 publications

Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats

Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats

Functional enrichment analysis based on long noncoding RNA associations

Insights into Brain Signal Transduction can Provide Potential Molecular Targets to Approach and Manage Alzheimer’s Disease

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