Enzyme-catalysed biodegradation of carbon dots follows sequential oxidation in a time dependent manner

Srivastava, Indrajit; Sar, Dinabandhu; Mukherjee, Prabuddha; Schwartz-Duval, Aaron S.; Huang, Zhaolu; Jaramillo, Camilo; Civantos, Ana; Tripathi, Indu; Allain, Jean Paul; Bhargava, Rohit; Pan, Dipanjan

doi:10.1039/c9nr00194h

Cited by 42 publications

(27 citation statements)

References 45 publications

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“…After intravenous injection, the majority of the fluorescence signals were collected from the liver, spleen, and kidneys, which indicated that the CDs were accumulated in those organs. 95 These findings provide additional information to understand the in vivo distribution of food-borne CDs.…”

Section: Main Textmentioning

confidence: 87%

Endogenous Fluorescence Carbon Dots Derived from Food Items

Wang

Tan

2020

The Innovation

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BACKGROUNDFluorescent carbon dots (CDs) are a novel class of carbon-based nanomaterials that were discovered in 2004. However, nobody knew that CDs existed in food items naturally until 2012. Properties of nanosize materials are distinct from those of their bulk materials due to the particle size and accordingly alter their bioavailability and/or biocompatibility. Therefore, the potential health risk of nanoparticles in food has drawn massive attention. Currently, almost all studies regarding the biosafety of nanoparticles in food have mainly focused on engineered nanoparticles used as food additives and have excluded the endogenous nanoparticles in food. Therefore, investigation of the properties of food-borne fluorescent CDs and their potential health risk to humans is of great significance.

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Section: Main Textmentioning

confidence: 87%

Endogenous Fluorescence Carbon Dots Derived from Food Items

Wang

Tan

2020

The Innovation

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“…They undergo peroxide catalyzed-degradation in the presence of a lipase. It was observed that the different charged CDs exhibit unique degradation kinetics through enzyme oxidation (Srivastava et al, 2019).…”

Section: Enzymatic Degradationmentioning

confidence: 99%

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath

Srivastava

2021

Front. Nanotechnol.

100

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With growing interest, a large number of researches have been conducted on carbon-based nanomaterials (CBNs). However, their uses are limited due to comprehensive potential environmental and human health effects. It is often confusing for researchers to make an informed choice regarding the versatile carbon-based nanocarrier system and its potential applications. This review has highlighted emerging applications and cutting-edge progress of CBNs in drug delivery. Some critical factors like enzymatic degradation, surface modification, biological interactions, and bio-corona have been discussed here. These factors will help to fabricate CBNs for effective drug delivery. This review also addresses recent advancements in carbon-based target specific and release controlled drug delivery to improve disease treatment. The scientific community has turned their research efforts into the development of novel production methods of CBNs to make their production more attractive to the industrial sector. Due to the nanosize and diversified physical properties, these CBNs have demonstrated distinct biological interaction. Thus long-term preclinical toxicity study is recommended before finally translating to clinical application.

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“…Enzymes can be covalently conjugated onto nanocarbons, adsorbed on their surface, or even encapsulated in those with a hollow structure, as reviewed elsewhere [ 2 , 3 , 4 , 5 ]. The interactions between proteins and nanocarbons can play an important role in determining their fate in vivo, including their biodegradation [ 6 , 7 , 8 ], formation of a biocorona [ 9 , 10 , 11 ], and consequent modulation of the immune response [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation

et al. 2022

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Carbon nanomaterials (CNMs) and enzymes differ significantly in terms of their physico-chemical properties—their handling and characterization require very different specialized skills. Therefore, their combination is not trivial. Numerous studies exist at the interface between these two components—especially in the area of sensing—but also involving biofuel cells, biocatalysis, and even biomedical applications including innovative therapeutic approaches and theranostics. Finally, enzymes that are capable of biodegrading CNMs have been identified, and they may play an important role in controlling the environmental fate of these structures after their use. CNMs’ widespread use has created more and more opportunities for their entry into the environment, and thus it becomes increasingly important to understand how to biodegrade them. In this concise review, we will cover the progress made in the last five years on this exciting topic, focusing on the applications, and concluding with future perspectives on research combining carbon nanomaterials and enzymes.

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Enzyme-catalysed biodegradation of carbon dots follows sequential oxidation in a time dependent manner

Abstract: Lipase mediated biodegradation of carbon dots in the presence H2O2 follows a sequential oxidation pathway.

Cited by 42 publications

References 45 publications

Endogenous Fluorescence Carbon Dots Derived from Food Items

Endogenous Fluorescence Carbon Dots Derived from Food Items

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation

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