Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath, Sujit Kumar; Srivastava, Rohit

doi:10.3389/fnano.2021.644564

Cited by 101 publications

(51 citation statements)

References 185 publications

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“…Carbon-based nanomaterials (CBNs) have attracted a great deal of attention in TDD research because of their unique structural dimensions and physicochemical features [193]. Strasinger et al [194] reported the use of various electrical biases to test the transdermal delivery of clonidine mediated by a carbon nanotube-epoxy nanocomposite membrane.…”

Section: Nanoparticlesmentioning

confidence: 99%

Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems

et al. 2022

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The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms but is as convenient and easy to use for the patient as oral solid dosage forms. In recent years, there has been increased interest in transdermal drug delivery (TDD) as a non-invasive delivery approach that is generally regarded as being easy to administer to more vulnerable age groups, such as paediatric and geriatric patients, while avoiding certain bioavailability concerns that arise from oral drug delivery due to poor absorbability and metabolism concerns. However, despite its many merits, TDD remains restricted to a select few drugs. The physiology of the skin poses a barrier against the feasible delivery of many drugs, limiting its applicability to only those drugs that possess physicochemical properties allowing them to be successfully delivered transdermally. Several techniques have been developed to enhance the transdermal permeability of drugs. Both chemical (e.g., thermal and mechanical) and passive (vesicle, nanoparticle, nanoemulsion, solid dispersion, and nanocrystal) techniques have been investigated to enhance the permeability of drug substances across the skin. Furthermore, hybrid approaches combining chemical penetration enhancement technologies with physical technologies are being intensively researched to improve the skin permeation of drug substances. This review aims to summarize recent trends in TDD approaches and discuss the merits and drawbacks of the various chemical, physical, and hybrid approaches currently being investigated for improving drug permeability across the skin.

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Section: Nanoparticlesmentioning

confidence: 99%

Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems

et al. 2022

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“…They can vary in length, diameter, layer count, and chirality. They possess appealing features due to their unusual blend of strength, stiffness, and elasticity [63]. Due to their outstanding physical and chemical qualities, such as an enormous surface-area-to-volume ratio, hollow structure, small diameter, electrical capabilities, and exceptional optical and high tensile strength, CNTs are used in a wide range of applications.…”

Section: Carbon Nanotubesmentioning

confidence: 99%

EGFR-Based Targeted Therapy for Colorectal Cancer—Promises and Challenges

et al. 2022

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Colorectal carcinoma (CRC) is the most lethal and common form of cancer in the world. It was responsible for almost 881,000 cancer deaths in 2018. Approximately 25% of cases are diagnosed at advanced stages with metastasis—this poses challenges for effective surgical control and future tumor-related mortality. There are numerous diagnostic methods that can be used to reduce the risk of colorectal carcinoma. Among these, targeted nanotherapy aims to eliminate the tumor and any metastasis. Active targeting can increase the effectiveness and quantity of drugs delivered to the target site. Antibodies that target overexpressed receptors on cell surfaces and indicators are coupled with drug-loaded carriers. The major target receptors of chemotherapeutic drugs delivery include VEGFR, EGFR, FGFR, HER2, and TGF. On account of its major and diverse roles in cancer, it is important to target EGFR in particular for better tumor selection, as EGFR is overexpressed in 25 to 82% of colorectal carcinoma cases. The EGFR monoclonal immunoglobulins cetuximab/panitumumab can thus be used to treat colorectal cancer. This review examines carriers that contain cetuximab-conjugated therapeutic drugs as well as their efficacy in anticancer activities.

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“…These nanomaterials have been employed for the targeted delivery of drugs or for cancer diagnosis. However, there is still concern about their toxicity for both humans and the environment [ 14 ], so most of their cancer-related applications are limited to their use in the development of sensors for cancer biomarkers. Their high surface area and excellent electrical conductivity [ 15 ] make them suitable candidates for the development of the electrochemical sensors used for the detection of biomarkers that are expressed in HCC [ 16 , 17 , 18 ].…”

Section: Types Of Nanoparticles Used For Diagnosis and Treatmentmentioning

confidence: 99%

Nanotechnology in the Diagnostic and Therapy of Hepatocellular Carcinoma

et al. 2022

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Hepatocellular carcinoma is the most common liver malignancy and is among the top five most common cancers. Despite the progress of surgery and chemotherapy, the results are often disappointing, in part due to chemoresistance. This type of tumor has special characteristics that allow the improvement of diagnostic and treatment techniques used in clinical practice, by combining nanotechnology. This article presents a brief review of the literature focused on nano-conditioned diagnostic methods, targeted therapy, and therapeutic implications for the pathology of hepatocellular carcinoma. Within each subdomain, several modern technologies with significant impact were highlighted: serological, imaging, or histopathological diagnosis; intraoperative detection; carrier-type nano-conditioned therapy, thermal ablation, and gene therapy. The prospects offered by nanomedicine will strengthen the hope of more efficient diagnoses and therapies in the future.

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Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Cited by 101 publications

References 185 publications

Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems

Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems

EGFR-Based Targeted Therapy for Colorectal Cancer—Promises and Challenges

Nanotechnology in the Diagnostic and Therapy of Hepatocellular Carcinoma

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