Enzyme-based biofuel cells for biosensors and in vivo power supply

Zhang, Jia Lei; Wang, Yi Han; Huang, Ke-Wei; Jiang, Hui; Wang, Xue Mei

doi:10.1016/j.nanoen.2021.105853

Cited by 82 publications

(42 citation statements)

References 140 publications

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“…CV and LSV were applied to evaluate the effect of different buffer solutions on the anode (Figure A,B). Compared with the solution without glucose (curve a), both CV and LSV curves shifted upward in the solution with glucose (curve b), and two redox peaks of GOD appear at −0.5 V. − The results confirm that the anode is sensitive to glucose and conforms to the O 2 -mediated mechanism of glucose oxidation by GOD. Concurrently, the results indicate the effective catalytic activity of the bioanode.…”

Section: Resultsmentioning

confidence: 62%

Matching Capacitors to Self-Powered Biosensors for Signal Amplification: Toward Ultrasensitive Electrochemical Detection for MicroRNA-21-Triggered Catalytic Hairpin Assembly

Wang

Hou

et al. 2022

ACS Sustainable Chem. Eng.

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A capacitor coupled with enzymatic biofuel cells (EBFCs) can deliver high-power instant output to obtain an amplified detection signal. Herein, matching a capacitor to a self-powered electrochemical biosensor for ultrasensitive determination of microRNA-21 is investigated. The detection system mainly combines a capacitor, EBFCs, and biological amplification technologies. Concretely, EBFCs are integrated into a capacitor-joined circuit, and the capacitor is automatically shorted by a switching regulator to provide an instantaneous current that is rapidly detected with a digital multimeter. A sensitivity of 38.72 μA/pM is achieved with the contribution of the matching capacitor, which is 6.96 times that without a capacitor. Moreover, the redox reaction on the anode leads to high-voltage outputs at low substrate concentrations and generates electrons when the target miRNA triggers a catalytic hairpin assembly cycle, while the release of the [Fe(CN) 6 ] 3− electron acceptor on the cathode is catalyzed to obtain a higher detection signal. As a result, the limit of detection of the developed biosensor is 0.18 fM (S/N = 3) with a linear range of 0.5−10 000 fM, which indicates that the innovative capacitor-matched self-powered biosensor holds great promise for ultrasensitive electrochemical biosensing.

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Section: Resultsmentioning

confidence: 62%

Matching Capacitors to Self-Powered Biosensors for Signal Amplification: Toward Ultrasensitive Electrochemical Detection for MicroRNA-21-Triggered Catalytic Hairpin Assembly

Wang

Hou

et al. 2022

ACS Sustainable Chem. Eng.

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“…The modern on-body wearable EFCs in the form of patches, tattoo, textiles, and contact lenses open the way for bioenergy harnessing and selfpowered biosensing. These non-invasive BFCs were employed to utilize bioenergy or monitoring biomarkers available in the biofluids like tears, saliva, fitness, sweat, and interstitial fluid (Zhang et al, 2021). But, the real-world application of potent wearable EFCs needs an efficient and excellent enzyme-electronic interface having a good electrochemical system and mechanical flexibility.…”

Section: Flexible Efcs For Wearable Devicesmentioning

confidence: 99%

Recent advancements in the field of flexible/wearable enzyme fuel cells

Haque

Yasir

Cosnier

2022

Biosensors and Bioelectronics

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“…In order to improve the sensitivity of ECL biosensors, various cyclic amplification strategies have been introduced, including hybridization chain reaction (HCR), rolling circle amplification (RCA), catalytic hairpin assembly (CHA), polymerase chain reaction (PCR) and so on [5] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] . These cyclic amplification strategies have complicated design processes and complicated secondary structures or require enzymes and variable temperature to participate in the reaction [29] , [30] . As a simple, isothermal, enzyme-free, and fast detection strategy, the entropy-driven reaction has been proposed in recent years [31] , [32] .…”

Section: Introductionmentioning

confidence: 99%

Rational engineering the DNA tetrahedrons of dual wavelength ratiometric electrochemiluminescence biosensor for high efficient detection of SARS-CoV-2 RdRp gene by using entropy-driven and bipedal DNA walker amplification strategy

Fan¹,

Yao

Ding³

et al. 2022

Chemical Engineering Journal

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Fast and effective detection of epidemics is the key to preventing the spread of diseases. In this work, we constructed a dual-wavelength ratiometric electrochemiluminescence (ECL) biosensor based on entropy-driven and bipedal DNA walker cycle amplification strategies for detection of the RNA-dependent RNA polymerase (RdRp) gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The entropy-driven cyclic amplification reaction was started by the SARS-CoV-2 RdRp gene to generate a bandage. The bandage could combine with two other single-stranded S1 and S2 to form a bipedal DNA walker to create the following cycle reaction. After the bipedal DNA walker completed the walking process, the hairpin structures at the top of the DNA tetrahedrons (TDNAs) were removed. Subsequently, the PEI-Ru@Ti 3 C 2 @AuNPs-S7 probes were used to combine with the excised hairpin part of TDNAs on the surface of Au-g-C 3 N 4 , and the signal change was realized employing electrochemiluminescence resonance energy transfer (ECL-RET). By combining entropy-driven and DNA walker cycle amplification strategy, the ratiometric ECL biosensor exhibited a limit of detection (LOD) as low as 7.8 aM for the SARS-CoV-2 RdRp gene. As a result, Detecting the SARS-CoV-2 RdRp gene in human serum still possessed high recovery so that the dual-wavelength ratiometer biosensor could be used in early clinical diagnosis.

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Enzyme-based biofuel cells for biosensors and in vivo power supply

Cited by 82 publications

References 140 publications

Matching Capacitors to Self-Powered Biosensors for Signal Amplification: Toward Ultrasensitive Electrochemical Detection for MicroRNA-21-Triggered Catalytic Hairpin Assembly

Matching Capacitors to Self-Powered Biosensors for Signal Amplification: Toward Ultrasensitive Electrochemical Detection for MicroRNA-21-Triggered Catalytic Hairpin Assembly

Recent advancements in the field of flexible/wearable enzyme fuel cells

Rational engineering the DNA tetrahedrons of dual wavelength ratiometric electrochemiluminescence biosensor for high efficient detection of SARS-CoV-2 RdRp gene by using entropy-driven and bipedal DNA walker amplification strategy

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