Enzymatically-tailored pectins differentially influence the morphology, adhesion, cell cycle progression and survival of fibroblasts

Nagel, Marie‐Danielle; Verhoef, René; Schols, Henk A.; Morra, Marco; Knox, John; Ceccone, Giacomo; Volpe, C. Della; Vigneron, Pascale; Bussy, Cyrill; Gallet, Marlène; Velzenberger, Elodie; Vayssade, Muriel; Cascardo, G.; Cassinelli, Clara; Haeger, Ash; Gilliland, Douglas; Liakos, Ioannis; Rodríguez-Valverde, Miguel A.; Siboni, S.

doi:10.1016/j.bbagen.2008.04.002

Cited by 30 publications

(53 citation statements)

References 55 publications

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“…Recently, it was reported that plant-derived polysaccharides, mainly Rhamnogalacturonan-I (RG-I) pectins, have potential to improve bone regeneration, [11][12][13] prevent inflammation, 14,15 and act as a delivery mechanism for therapeutic agents. 15 RG-I is the first molecule derived from plants that has been introduced and tested as a potential nanocoating to be applied to biomaterial surfaces, for example, titanium, to improve bone healing and osseointegration.…”

Section: Introductionmentioning

confidence: 99%

“…15 RG-I is the first molecule derived from plants that has been introduced and tested as a potential nanocoating to be applied to biomaterial surfaces, for example, titanium, to improve bone healing and osseointegration. 11,16 RG-I is a subunit of pectin composed of a backbone of alternating rhamnose (Rha) and galacturonic acid (GalA) residues, whereas arabinian and (arabino-)galactan side chains are present on the rhamnosyl residues.…”

Section: Introductionmentioning

confidence: 99%

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Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following <em>Porphyromonas gingivalis</em> infection

Meresta¹,

Folkert²,

Gaber³

et al. 2017

IJN

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following <em>Porphyromonas gingivalis</em> infection

Meresta¹,

Folkert²,

Gaber³

et al. 2017

IJN

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“…Pectin fragments formed by enzymatic treatments consist of modified hairy regions (MHR), which may be used in the coating of biomedical devices, according to their chemical, physical and biological properties. In particular, MHR fragments can be considered as nanocoatings forming a 6-10 nm thick layer covalently linked onto varies surfaces [33][34][35][36]. [37,38].…”

Section: Pectinsmentioning

confidence: 99%

“…Thus, pectins are nowadays under enthusiastic investigation in the biomaterial field as novel candidates for soft and hard tissue engineering and dental titanium coating [32,33,35,36,44]. Promising in vitro and in vivo results indicate the possibility of using enzymatically modified apple pectin fragments as dental implant nano-coatings [13,45].…”

Section: Pectinsmentioning

confidence: 99%

“…Modified pectic nano-coating in vitro appears to be a promising direction to enhance the biocompatibility of bone and dental implants [45]. In particular, the authors explained the higher activity of MHRs-B by considering the relationship between cellular preference and surface wettability [32,47]: more hydrophobic MHRs-B were markedly more biocompatible than the more wettable MHRs-A [48].…”

Section: Pectinsmentioning

confidence: 99%

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Plant Products for Innovative Biomaterials in Dentistry

Varoni

Rimondini

2012

Coatings

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Dental biomaterials and natural products represent two of the main growing research fields, revealing plant-derived compounds may play a role not only as nutraceuticals in affecting oral health, but also in improving physico-chemical properties of biomaterials used in dentistry. Therefore, our aim was to collect all available data concerning the utilization of plant polysaccharides, proteins and extracts rich in bioactive phytochemicals in enhancing performance of dental biomaterials. Although compelling evidences are suggestive of a great potential of plant products in promoting material-tissue/cell interface, to date, only few authors have investigated their use in development of innovative dental biomaterials. A small number of studies have reported plant extract-based titanium implant coatings and periodontal regenerative materials. To the best of our knowledge, this review is the first to deal with this topic, highlighting a general lack of research findings in an interesting field which still needs to be investigated.

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Polysaccharide Nanobiotechnology: A Case Study of Dental Implant Coating

Morra¹,

Cassinelli²,

Cascardo³

et al. 2018

Annual Plant Reviews Online

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Surface modification of biomaterials and medical devices by polysaccharides is presently a topic of great interest, both at fundamental and applied levels. Plant polysaccharides constitute an untapped resource in this regard. The very self‐assembly properties of the polymers that the plant cell exploits during cell wall biogenesis may be exploited in assembly of contiguous coatings of medical devices and implants. Cell wall polysaccharides not only display advantageous physical properties but some are also known to be biologically active in a mammalian context. Bioactivities include anti‐inflammatory and immunomodulatory effects that are hypothesized to suppress rejection and promote implant integration. These activities are in most cases associated with polysaccharides of the pectin family. The present study thus focuses on engineering biocompatible surfaces using rhamnogalacturonan‐I. The target application is titanium dental implants and the study reports extensively on the methods used for surface characterization, both biological methods that probe biocompatability and nanotechnology methods used for the physical characterization of the modified surfaces.

show abstract

Enzymatically-tailored pectins differentially influence the morphology, adhesion, cell cycle progression and survival of fibroblasts

Cited by 30 publications

References 55 publications

Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following <em>Porphyromonas gingivalis</em> infection

Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following <em>Porphyromonas gingivalis</em> infection

Plant Products for Innovative Biomaterials in Dentistry

Polysaccharide Nanobiotechnology: A Case Study of Dental Implant Coating

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