Enzymatically derived sunflower protein hydrolysate and peptides inhibit NFκB and promote monocyte differentiation to a dendritic cell phenotype

Velliquette, Rodney A.; Fast, David J.; Maly, Eugene R.; Alashi, Adeola M.; Aluko, Rotimi E.

doi:10.1016/j.foodchem.2020.126563

Cited by 33 publications

(15 citation statements)

References 38 publications

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“…1) Bioactive peptides are protein fragments with up to 20 amino acid residues and that have an impact on body functions, which depend on their composition and amino acid sequence in the structure (Lemes et al, 2016b). Due to their high protein value, cakes and meals can serve as a source of peptides or amino acids that, once released, demonstrate higher biological activity such as antioxidant, antihypertensive, anti-inflammatory, and immune-modulating activities (Lemes et al, 2016b;Lemes et al, 2020b;Velliquette et al, 2020).…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Biological Approaches for Extraction of Bioactive Compounds From Agro-industrial By-products: A Review

Lemes

Egea

Filho

et al. 2022

Front. Bioeng. Biotechnol.

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Bioactive compounds can provide health benefits beyond the nutritional value and are originally present or added to food matrices. However, because they are part of the food matrices, most bioactive compounds remain in agroindustrial by-products. Agro-industrial by-products are generated in large quantities throughout the food production chain and can—when not properly treated—affect the environment, the profit, and the proper and nutritional distribution of food to people. Thus, it is important to adopt processes that increase the use of these agroindustrial by-products, including biological approaches, which can enhance the extraction and obtention of bioactive compounds, which enables their application in food and pharmaceutical industries. Biological processes have several advantages compared to nonbiological processes, including the provision of extracts with high quality and bioactivity, as well as extracts that present low toxicity and environmental impact. Among biological approaches, extraction from enzymes and fermentation stand out as tools for obtaining bioactive compounds from various agro-industrial wastes. In this sense, this article provides an overview of the main bioactive components found in agroindustrial by-products and the biological strategies for their extraction. We also provide information to enhance the use of these bioactive compounds, especially for the food and pharmaceutical industries.

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Section: Bioactive Compoundsmentioning

confidence: 99%

Biological Approaches for Extraction of Bioactive Compounds From Agro-industrial By-products: A Review

Lemes

Egea

Filho

et al. 2022

Front. Bioeng. Biotechnol.

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“…Peptides derived from sunflower seed ( Helianthus annuus L.) also present bioactive properties [ 42 ]. Four small and non-polar peptides were obtained, sequenced (YFVP, SGRDP, MVWGP and TGSYTEGWS) and tested in THP-1 cells (ATCC ® TIB-202™).…”

Section: Anti-inflammatory Mechanisms Of Action Of Purified Peptides ...mentioning

confidence: 99%

“…The peptide containing the Met residue presented the most promising anti-inflammatory and immunomodulatory effect among the four studied peptides of sunflower seed. According to the authors, the explanation is not completely clear [ 42 ]. However, the Met is a precursor of S-adenosil-L-methionine (SAMe or AdoMet), which is an enzyme with potential alkylating, a methyl donor, actively participating in numerous biochemical processes, such as a glutathione precursor (GSH), which acts in the detoxification process [ 43 , 44 ].…”

Section: Anti-inflammatory Mechanisms Of Action Of Purified Peptides ...mentioning

confidence: 99%

“…Moreover, in relation to the NF-κB pathway, the hydrolyzed proteins of beans from the black 8025 (N), Pinto Durango (P) [ 26 ] and SBP varieties [ 24 ]; and peptides extracted from corn (zein) [ 45 ] and sunflower [ 42 ] were able to reduce NF-κB activity, consequently decreasing the expression of inflammatory cytokines, COX-2 and iNOS.…”

Section: Metabolic Pathways Of Inflammation In Obesity: Potential The...mentioning

confidence: 99%

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Hydrolyzed Proteins and Vegetable Peptides: Anti-Inflammatory Mechanisms in Obesity and Potential Therapeutic Targets

et al. 2022

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Chronic low-grade inflammation is present in overweight and obesity, causing changes in several metabolic pathways. It impairs systemic functioning and positively feeds back the accumulation of more adipose tissue. Studies with hydrolyzed proteins and plant peptides have demonstrated a potential anti-inflammatory and immunomodulatory effect of these peptides. However, it is challenging and necessary to explore the mechanism of action of such molecules because understanding their effects depends on their structural characterizations. Furthermore, the structure might also give insights into safety, efficacy and efficiency, with a view of a possible health application. Thus, the present narrative review aimed to discuss the mechanisms of action of hydrolyzed proteins and plant peptides as anti-inflammatory agents in obesity. Keywords and related terms were inserted into databases for the search. Based on the studies evaluated, these biomolecules act by different pathways, favoring the reduction of inflammatory cytokines and adipokines and the polarization of macrophages to the M2 phenotype. Finally, as a future perspective, bioinformatics is suggested as a tool to help understand and better use these molecules considering their applicability in pre-clinical and clinical studies.

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“…ACE: Angiotensin-converting enzyme; ABTS: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid); DPPH: 2,2-diphenyl-1-picrylhydrazyl; TE: Trolox equivalent; MIC: minimum inhibitory concentration; IC50: the half-maximal inhibitory concentration; NFκB: factor nuclear kappa B; CD14: a cluster of differentiation 14; CD86: a cluster of differentiation; DC: Dendritic cells; MW: molecular weight; MRP: Maillard reaction products Finally, protein hydrolysates and/or peptides obtained from sunflower byproduct have demonstrated important biological activities in human health such as antioxidant (Dabbour, He, Mintah, et al, 2019;Dabbour, He, Mintah, Xiang, et al, 2019;Habinshuti et al, 2019;Megías et al, 2009;Prado et al, 2020) and antihypertensive Luo & He, 2018;Megías et al, 2009) activities, as well as anti-inflammatory and immune-modulating effects (Velliquette et al, 2020), yet demonstrating no side effects caused by signs of toxicity (Canistro et al, 2017).…”

Section: Bao Et Al (2020)mentioning

confidence: 99%

Sunflower seed byproduct and its fractions for food application: An attempt to improve the sustainability of the oil process

Filho

Egea

2021

Journal of Food Science

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The sunflower (Helianthus annus L.) is one of the main oil crops in the world grown for the production of edible and biodiesel oil. Byproducts of the extraction of sunflower oil constitute a raw material with potential for several applications in the food area due to its chemical composition, including the high content of proteins and phenolic compounds. Thoughtful of a consumer increasingly concerned with the environmental impact, we try to clarify in this review the potential of using sunflower seed byproducts and their fractions to enhance the production of potentially functional foods. The applications of sunflower seed byproduct include its transformation into flours/ingredients that are capable of improving the nutritional and functional value of foods. In addition, the protein isolates obtained from sunflower seed byproduct have good technological properties and improve the nutritional value of food products. These protein isolates can be used to obtain protein hydrolysates with technological and bioactive properties and as matrices for the development of edible, biodegradable, and active films for food. The sunflower seed byproduct is also a source of phenolic compounds with bioactive properties, mainly chlorogenic acid, which can be extracted by different methods and applied in the development of functional foods and active and bioactive food packaging. The use of sunflower seed byproduct and its fractions are promising ingredients for the development of healthier and less expensive foods as well as the alternative to decrease the environmental problems caused by the sunflower oil industry.

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Enzymatically derived sunflower protein hydrolysate and peptides inhibit NFκB and promote monocyte differentiation to a dendritic cell phenotype

Cited by 33 publications

References 38 publications

Biological Approaches for Extraction of Bioactive Compounds From Agro-industrial By-products: A Review

Biological Approaches for Extraction of Bioactive Compounds From Agro-industrial By-products: A Review

Hydrolyzed Proteins and Vegetable Peptides: Anti-Inflammatory Mechanisms in Obesity and Potential Therapeutic Targets

Sunflower seed byproduct and its fractions for food application: An attempt to improve the sustainability of the oil process

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