Enzymatic synthesis of phenolic lipids using flaxseed oil and ferulic acid in supercritical carbon dioxide media

Ciftci, Deniz; Saldaña, Marleny D.A.

doi:10.1016/j.supflu.2012.09.007

Cited by 29 publications

(6 citation statements)

References 33 publications

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“…One hundred twenty kilograms of diferuloyl glycerol by-product could be isolated annually. Enzymatic esterification of olive, flaxseed, and fish oil offers low cost and greener configurations to the process (Ciftci and Saldana 2012 ; Yang et al 2012 ; Radzi et al 2014 ). Transesterification of ethyl ferulate with castor oil, catalyzed by CALB, yielded 62.6 % lipophilic and 37.3 % hydrophilic products (Sun et al 2014 ).…”

Section: Esterasesmentioning

confidence: 99%

Enzymatic synthesis of bioactive compounds with high potential for cosmeceutical application

Αντωνοπούλου

Varriale

Topakas

et al. 2016

Appl Microbiol Biotechnol

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Cosmeceuticals are cosmetic products containing biologically active ingredients purporting to offer a pharmaceutical therapeutic benefit. The active ingredients can be extracted and purified from natural sources (botanicals, herbal extracts, or animals) but can also be obtained biotechnologically by fermentation and cell cultures or by enzymatic synthesis and modification of natural compounds. A cosmeceutical ingredient should possess an attractive property such as anti-oxidant, anti-inflammatory, skin whitening, anti-aging, anti-wrinkling, or photoprotective activity, among others. During the past years, there has been an increased interest on the enzymatic synthesis of bioactive esters and glycosides based on (trans)esterification, (trans)glycosylation, or oxidation reactions. Natural bioactive compounds with exceptional theurapeutic properties and low toxicity may offer a new insight into the design and development of potent and beneficial cosmetics. This review gives an overview of the enzymatic modifications which are performed currently for the synthesis of products with attractive properties for the cosmeceutical industry.

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Section: Esterasesmentioning

confidence: 99%

Enzymatic synthesis of bioactive compounds with high potential for cosmeceutical application

Αντωνοπούλου

Varriale

Topakas

et al. 2016

Appl Microbiol Biotechnol

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“…More recently, yields improved using supercritical carbon dioxide as the reaction medium [ 345 ]. The prepared mixtures of lipidic phenols were tested for antioxidant activity.…”

Section: Lipidic Phenolsmentioning

confidence: 99%

Tailored Functionalization of Natural Phenols to Improve Biological Activity

et al. 2021

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Phenols are widespread in nature, being the major components of several plants and essential oils. Natural phenols’ anti-microbial, anti-bacterial, anti-oxidant, pharmacological and nutritional properties are, nowadays, well established. Hence, given their peculiar biological role, numerous studies are currently ongoing to overcome their limitations, as well as to enhance their activity. In this review, the functionalization of selected natural phenols is critically examined, mainly highlighting their improved bioactivity after the proper chemical transformations. In particular, functionalization of the most abundant naturally occurring monophenols, diphenols, lipidic phenols, phenolic acids, polyphenols and curcumin derivatives is explored.

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“…It has many properties including antioxidant [ 15 ], antiatherosclerotic [ 16 ], and anti-inflammatory [ 17 ]. Flaxseed oil has been shown to enhance the function of the antioxidant system due to its antioxidant compounds such as phenols and vitamin E. It also reduces blood lipids and inflammation by increasing LDL receptors leading to reducing MDA either [ 18 , 19 ]. However, the results of studies about the effect of flaxseed oil on oxidative stress parameters are conflicting [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Flaxseed Oil Supplementation Augments Antioxidant Capacity and Alleviates Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Musazadeh

Jafarzadeh

Keramati

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Studies have reported controversial findings regarding the flaxseed oil effect on antioxidant status biomarkers. The present meta-analysis aimed to determine the impact of flaxseed oil on the serum level of biomarkers of oxidative stress. Methods. A systematic search was conducted up to November 2020 on PubMed, Embase, Web of Science, Scopus, and Cochrane Central Library. Random-effects model was employed to perform meta-analysis. Subgroup analysis was carried out to determine the effect across different ranges of dosages and durations. Results. Eight trials were included with a total sample size of 429 individuals with a mean age range of 25 to 70 years. The results indicated that flaxseed oil supplementation led to a significant decrease in malondialdehyde (MDA) levels (SMD: −0.52 μmol/L; 95% CI: −0.89, −0.15; P = 0.006 , I2 = 71.3, P < 0.001 ) and increase in total antioxidant capacity (TAC) levels (WMD: 82.84 mmol/L; 95% CI: 19.80, 145.87; P = 0.006 , I2 = 92.7, P < 0.001 ). No significant effect was observed on glutathione (GSH). Conclusion. Our findings revealed that flaxseed oil supplementation might play a beneficial role in the reinforcement of the antioxidant defense system and amelioration of oxidative stress in adults.

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Enzymatic synthesis of phenolic lipids using flaxseed oil and ferulic acid in supercritical carbon dioxide media

Cited by 29 publications

References 33 publications

Enzymatic synthesis of bioactive compounds with high potential for cosmeceutical application

Enzymatic synthesis of bioactive compounds with high potential for cosmeceutical application

Tailored Functionalization of Natural Phenols to Improve Biological Activity

Flaxseed Oil Supplementation Augments Antioxidant Capacity and Alleviates Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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