Enzymatic synthesis of bioactive compounds with high potential for cosmeceutical application

Abstract

Cosmeceuticals are cosmetic products containing biologically active ingredients purporting to offer a pharmaceutical therapeutic benefit. The active ingredients can be extracted and purified from natural sources (botanicals, herbal extracts, or animals) but can also be obtained biotechnologically by fermentation and cell cultures or by enzymatic synthesis and modification of natural compounds. A cosmeceutical ingredient should possess an attractive property such as anti-oxidant, anti-inflammatory, skin whitening, anti-aging, anti-wrinkling, or photoprotective activity, among others. During the past years, there has been an increased interest on the enzymatic synthesis of bioactive esters and glycosides based on (trans)esterification, (trans)glycosylation, or oxidation reactions. Natural bioactive compounds with exceptional theurapeutic properties and low toxicity may offer a new insight into the design and development of potent and beneficial cosmetics. This review gives an overview of the enzymatic modifications which are performed currently for the synthesis of products with attractive properties for the cosmeceutical industry.

Health and Beauty Cosmeceuticals Industry and Market Expansion in Saudi Arabia

“…Moreover cutting-edge technological transformation continue to stimulate new lifestyle adaptations, globalization related behavioural and cultural influences that enhance people and community perception and fashion on the acceptance, uptake and utilization of cosmeceuticals [8][9][10][11]. The enabling environment and appropriate pharmaceuticals or cosmeceuticals regulations and requirements provide ample cosmeceuticals market landscape investment opportunities in Saudi Arabia [9][10][11][12]13]. Over the last decade, strong commitment and investment that is responsible for rapid growth is expected to be competitive due to increasing consumers quality and brand demand and value-priced products driven by digital marketing and advertising awareness among customers for better health and wellness.…”

“…Local cosmetics firms' production and market have the opportunity to increasing their momentum with over 27 pharmaceutical manufacturers operating in the Kingdom and accounting for about 18% of the national market value from generic branded manufacturing [6,9,42]. Domestic players are mostly focused on branded generics manufacturing or license agreement with Pfizer, GSK and J&J pharmaceutical firms [43,44].…”

“…The rapid cosmetics growth including the Saudi beauty and personal care industries in recent years has been astonishing based on several boosters factors such as growing young population, increasing disposable incomes and expansion of domestic and foreign cosmetics brands [7][8][9][10][11]. In addition, increasing internet marketing and online shopping sites, media advertisements and establishment of Western brands shops in major cities continue to promote brand awareness that shape cosmetics consumer behaviour and new fashionable culture.…”

“…In addition, increasing internet marketing and online shopping sites, media advertisements and establishment of Western brands shops in major cities continue to promote brand awareness that shape cosmetics consumer behaviour and new fashionable culture. These, coupled with annual Muslims pilgrims' population and tourists, thus are increasing the demand for diverse personal care and beauty products in major cities in the Kingdom [9][10][11][12][13][14][15].…”

Identification and Crystallographic Analysis of a New Carbohydrate Acetylesterase (SmAcE1) from Sinorhizobium meliloti

“…In the physiological aspect, CEs are considered to be involved in the formation of cell walls, interactions between host and microbes, and energy metabolism pathways [7][8][9][10][11][12][13][14][15]. CEs are also important for biotechnological application, as modifications of carbohydrates are necessary for the preparation of biofuel, drug carriers, and cosmetics [16][17][18]. To date, based on the sequence similarities and the presence of characteristic carbohydrate binding modules, CEs can be classified into fifteen subfamilies from CE1 to CE16.…”