Enzootic intranasal tumour virus infection in apparently healthy sheep in Japan

Transboundary and Emerging Diseases

Yan

et al. 2010

This is the first report on enzootic nasal adenocarcinoma (ENA) in goats (Nanjiang Yellow goats and Jianyang Big-ear Black goats) in southwestern China. The clinical, histological and ultrastructural features of ENA in goats were described. From July 2007 to May 2009, 21 cases of ENA in goats, from 6 months to 8 years old, were diagnosed solely in one big herd. Clinically, the affected goats showed nasal discharge, facial swelling, sneezing, stertorous breathing and weight loss. Tumours that originated from the ethmoid area of the nasal cavity were unilateral (18/21) or bilateral (3/21). All tumours were classified as low grade adenocarcinomas by histopathological examination and were displayed a combination of tubular and papillary growth. No metastases were detected in regional lymph nodes, brain or other organs. Ultrastructurally, virus-like particles with an average diameter between 80 and 110 nm were observed in 5/7 examined tumours.

supporting

confidence: 83%

Descriptive Study of Enzootic Nasal Adenocarcinoma in Goats in Southwestern China

Geng

Transboundary and Emerging Diseases

Yan

et al. 2010

“…Enzootic nasal adenocarcinoma (ENA) is an epithelial tumor caused by enzootic nasal tumor virus (ENTV), and is a chronic, progressive, contact transmitted disease(Heras et al 2003). With the exception of Australia and New Zealand, this disease has spread throughout goats or sheep almost worldwide (Kawasako et al 2005). ENA originates from the ethmoid area of the nasal cavity either unilaterally or bilaterally, and the tumors are soft, whitish or pinkish-red in color and can partially or completely obscure the nasal cavity(Walsh et al 2010).…”

mentioning

confidence: 99%

Identification of Novel and Differentially Expressed MicroRNAs in Goat Enzootic Nasal Adenocarcinoma

Cao

et al. 2016

Preprint

Background: MicroRNAs (miRNAs) post-transcriptionally regulate a variety of genes involved in eukaryotic cell growth, development, metabolism and other biological processes, and numerous miRNAs are implicated in the initiation and progression of cancer. Enzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in goats and sheep by enzootic nasal tumor virus (ENTV), is a chronic, progressive, contact transmitted disease.

“…With the exception of Australia and New Zealand, this disease has spread throughout goats or sheep almost worldwide [26]. ENA originates from the ethmoid area of the nasal cavity either unilaterally or bilaterally, and the tumors are soft, whitish or pinkish-red in color and can partially or completely obscure the nasal cavity [27].…”

Section: Introductionmentioning

confidence: 99%

Identification of novel and differentially expressed MicroRNAs in goat enzootic nasal adenocarcinoma

Cao

et al. 2016

BMC Genomics

BackgroundMicroRNAs (miRNAs) post-transcriptionally regulate a variety of genes involved in eukaryotic cell growth, development, metabolism and other biological processes, and numerous miRNAs are implicated in the initiation and progression of cancer. Enzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in goats and sheep by enzootic nasal tumor virus (ENTV), is a chronic, progressive, contact transmitted disease.MethodsIn this work, small RNA Illumina high-throughput sequencing was used to construct a goat nasal miRNA library. This study aimed to identify novel and differentially expressed miRNAs in the tumor and para-carcinoma nasal tissues of Nanjiang yellow goats with ENA.ResultsFour hundred six known miRNAs and 29 novel miRNAs were identified. A total of 116 miRNAs were significantly differentially expressed in para-carcinoma nasal tissues and ENA (54 downregulated; 60 upregulated; two only expressed in control group); Target gene prediction and functional analysis revealed that 6176 non-redundancy target genes, 1792 significant GO and 97 significant KEGG pathway for 121 miRNAs (116 significant expression miRNAs and five star sequence) were predicted. GO and KEGG pathway analysis revealed the majority of target genes in ENA are involved in cell proliferation, signal transduction and other processes associated with cancer.ConclusionsThis is the first large-scale identification of miRNAs in Capra hircus ENA and provides a theoretical basis for investigating the complicated miRNA-mediated regulatory networks involved in the pathogenesis and progression of ENA.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3238-5) contains supplementary material, which is available to authorized users.