Environmental toxicity study of poly(2-oxazoline)s

Hrdlička, Lukáš; Šrámková, Petra; Prousek, Josef; Kronek, Juraj

doi:10.1007/s11696-018-0410-1

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…PMetOx of different degrees of polymerization (DP) were prepared through living cationic ringopening polymerization of 2-methyl-2-oxazoline, initiated by methyl 4-nitrobenzenesulfonate (MeONs) according to a standard procedure. [40,41] The polymerizations were performed in ACN solution (4 mol L −1 ) at 80 C for 23 or 88 hr giving respectively DP of 50 or 200. The reactions were terminated by 0.1 M methanolic KOH (1.1 equivalents to MeONs).…”

Section: Synthesis Of Pmetox-co-pei Copolymersmentioning

confidence: 99%

DNA delivery systems based on copolymers of poly (2‐methyl‐2‐oxazoline) and polyethyleneimine: Effect of polyoxazoline moieties on the endo‐lysosomal escape

Haladjova

Smolíček

Ugrinova

et al. 2020

J of Applied Polymer Sci

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Poly(2‐methyl‐2‐oxazoline)‐polyethylenimine (PMeOx‐co‐PEI) copolymers differing by degree of polymerization (DP = 50 and 200) and PEI content (from 37 to 99 mol%) were synthesized by living cationic ring‐opening polymerization of 2‐methyl‐2‐oxazoline, followed by partial hydrolysis. Upon mixing with DNA in a wide range of N/P ratios, they formed well‐defined polyplex particles of small size (typically below 100 nm) and narrow size distribution. The polyplexes demonstrated good colloidal stability and very low in vitro cytotoxicity. The copolymers exhibited buffering capacity of over 50% relative to that of the reference PEI implying effective endo‐lysosomal escape of the polyplexes. Increased cellular internalization of both PCR fragments and plasmid DNA, attributable to the strongly positive ζ potential and small size of the polyplexes, was observed. In spite of these favorable prerequisites, the transfection efficiency was low (below 20% relative to the control PEI) and was attributed to retarded swelling of the polyplex particles, endo‐lysosomal rupture, and DNA release.

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Section: Synthesis Of Pmetox-co-pei Copolymersmentioning

confidence: 99%

DNA delivery systems based on copolymers of poly (2‐methyl‐2‐oxazoline) and polyethyleneimine: Effect of polyoxazoline moieties on the endo‐lysosomal escape

Haladjova

Smolíček

Ugrinova

et al. 2020

J of Applied Polymer Sci

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“…With folic acid as a model drug mixed into TEA (PCL-b-PVP) 3 micelles, the drug loading and encapsulation efficiency were 16.36% and 49.08%, respectively [167]. POx is also called "pseudopeptides" as a result of its structure similar to poly (amino acid) [168]. Similarly, it has become another substitute for PEG, due to its biocompatibility, high degree of solubility adjustment, size change, structure and chemical function.…”

Section: Synthetic Polymermentioning

confidence: 99%

“…An inherent problem of carrier nanomedicine is that its drug-carrying capacity is still low (usually <10 wt%), which hinders the accumulation of effective drugs and the therapeutic effects of drugs. The drug inertness of the nanocarrier and the excessive chemical treatment during the preparation process will bring potential harm to the body [167,168]. In order to avoid these hazards, carrier-free nanomedicines, whose nanomaterial matrix is mainly composed of active pharmaceutical ingredients, were developed.…”

Section: Carrier-free Nanomedicines Delivery Systemmentioning

confidence: 99%

Optimization of Nanoparticles for Smart Drug Delivery: A Review

et al. 2021

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Nanoparticle delivery systems have good application prospects in the treatment of various diseases, especially in cancer treatment. The effect of drug delivery is regulated by the properties of nanoparticles. There have been many studies focusing on optimizing the structure of nanoparticles in recent years, and a series of achievements have been made. This review summarizes the optimization strategies of nanoparticles from three aspects—improving biocompatibility, increasing the targeting efficiency of nanoparticles, and improving the drug loading rate of nanoparticles—aiming to provide some theoretical reference for the subsequent drug delivery of nanoparticles.

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“…as the polymeric fertilizer, with the potential to slowly release nitrogen that can be metabolized by plants. As an example, De Varennes et al examined the stimulation effect of polyacrylates neutralized with NH 4 + ions on ryegrass growth and development [32] and, recently, Hrdlička et al demonstrated a different sphytotoxicological effect of selected poly(2-oxazoline)s on the growth of Sinapis alba [33].…”

Section: Introductionmentioning

confidence: 99%

Poly(methylene-co-cyanoguanidine) as an Eco-friendly Nitrogen Fertilizer with Prolonged Activity

et al. 2019

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Poly(methylene-co-cyanoguanidine), PMCG, is an oligomeric polycation that has found its application in the waste-water treatment as well as in preparation of polyelectrolyte complex microcapsules for biomedical purposes. Considering the nitrogen-rich composition of repeating unit, PMCG may be a valuable polycation utilized as a novel slow-release fertilizer. The aim of this study was to evaluate the potential of PMCG as a nitrogen fertilizer during its 6-month incubation in the soil. Monocotyledonous oat (Avena sativa) and dicotyledonous radish (Raphanus sativus L.) were selected as representative model plants for plant growth test. The effect of PMCG on plant growth and development was dependent on both the PMCG concentration and time of incubation. An increase in the nitrogen amount in green parts of plants demonstrated the uptake of the plant-available form of nitrogen released from PMCG incubated in the soil. This resulted in an increased percentage of fresh matter and shoot height of the tested plants during their exposure to PMCG. Ecotoxicological impact of PMCG in the soil during incubation period against bacteria Allivibrio fischeri and crustacean Heterocypris incongruens was also assessed. PMCG was found as the potential polymer fertilizer that does not require special treatment and can be used as it is for the prolonged release of nitrogen in agriculture.

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Environmental toxicity study of poly(2-oxazoline)s

Cited by 6 publications

References 20 publications

DNA delivery systems based on copolymers of poly (2‐methyl‐2‐oxazoline) and polyethyleneimine: Effect of polyoxazoline moieties on the endo‐lysosomal escape

DNA delivery systems based on copolymers of poly (2‐methyl‐2‐oxazoline) and polyethyleneimine: Effect of polyoxazoline moieties on the endo‐lysosomal escape

Optimization of Nanoparticles for Smart Drug Delivery: A Review

Poly(methylene-co-cyanoguanidine) as an Eco-friendly Nitrogen Fertilizer with Prolonged Activity

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