Environmental roles and biological activity of domoic acid: A review

Zabaglo, Kornelia; Chrapusta, Ewelina; Bober, Beata; Kamiński, Ariel; Adamski, Michał; Białçzyk, Jan

doi:10.1016/j.algal.2015.11.020

Cited by 54 publications

(40 citation statements)

References 119 publications

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“…Биологической активности и роли в окружающей среде домоевой кислоты (нейротоксина), выде-ляемой несколькими видами диатомовой водоросли Pseudo-nitzschia, посвящён и обзор [78]. Согласно одной из гипотез, экологическая роль домоевой кислоты -быть детеррентом (отпугивающим веще-ством) от выедания консументами [46].…”

Section: сигналинг в водных экосистемахunclassified

Современные Тенденции Развития Биологии Водных Экосистем

Likhoshvai

2017

mbj

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Охарактеризованы новые направления океанологии, сформированные в последние несколько лет бла-годаря внедрению в практику современных методов получения и обработки данных. Это методы мас-сового секвенирования, «омики» и биоинформационные методы хранения и анализа данных. Выяв-ление биологически активных веществ в водной среде и результаты лабораторных экспериментов по-казывают, что существует молекулярное взаимодействие (сигналинг) как на уровне популяционных и межвидовых отношений между микроорганизмами, так и на уровне их трофических связей. «От мо-лекул к экосистеме» -так охарактеризовано актуальное направление биологии морских экосистем. Объединение и анализ огромных массивов данных, включая полученные с помощью космических съё-мок и «облачных» технологий, сформировали новое направление экоинформатики, которое примени-тельно к водным экосистемам позволяет приблизиться к пониманию их структурно-функциональной организации в целом.Ключевые слова: биология водных экосистем, «омики», большие данные, сигналинг

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Section: сигналинг в водных экосистемахunclassified

Современные Тенденции Развития Биологии Водных Экосистем

Likhoshvai

2017

mbj

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“…Some of the marine phytoplankton produces these algae, such as dinoflagellates. These algae then produce phycotoxins, which are therapeutic [1] and hence include toxic activities [2]. The algal blooms do not only accumulate the DA in the shellfish but also in various other fishes such as anchovies and sardines.…”

Section: Introductionmentioning

confidence: 99%

“…The human could only be exposed to the consumption of DA if they consume a specific amount of these contaminated shellfish, which means the shellfishes have accumulated this toxin at the time of its filter-feeding during blooms on toxigenic phytoplankton [4]. The impact held by these phycotoxins on the health of the humans is divided into six types in accordance with its effects on human [2]. They are vomiting, vertigo and nausea due to neurotoxic shellfish poisoning [5] and, necrosis in specific regions of the hippocampus and neuronal degeneration due to amnesic shellfish poisoning [6].…”

Section: Introductionmentioning

confidence: 99%

Proliferative effect of the phycotoxin domoic acid on cancer cell lines: a preliminary evaluation

Ayed

Kouidhi

Kassim

et al. 2018

Journal of Taibah University for Science

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Domoic acid (DA) is a neurotoxin that causes amnesic shellfish poisoning. It is produced by algae and accumulates in shellfish. Consumption of these contaminated shellfishes is suspected to produce exceptional health hazards for humans. Effect of DA on cancer cell lines remained unclear. Human endothelial cells EA.hy 927, Human leukaemia K562 cells and monkey kidney Vero cells were used to evaluate the cytotoxicity of DA. Concentrations ranging from 30 to 120 µM of DA and using Neutral Red and MTT assays demonstrated that this neurotoxin undertook promotion of cell proliferation of the three cell lines in a dosedependent manner in contrast to untreated control cells, after incubation for 72 h. An increase in the percentage of proliferation was induced by a 120 µM of DA. The proliferation of K562 cells is encouraged by DA more than Vero and EA.hy 927 cells. The study highlighted the activity of DA in vitro. This could be taken as reflecting the tumorigenic compound of DA. For establishment of the carcinogenic potential of DA, there is a requirement of further investigations. ARTICLE HISTORY

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“…In humans, symptoms of ASP include both gastrointestinal (vomiting and diarrhoea) and neurological effects (short-term memory loss, confusion, seizures, coma, and even death) 6 . Since the incident in Canada, DA has been found in 21 1 . Accumulation of DA in bivalves was also reported from various parts of the world 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Biotoxin outbreaks in marine, estuarine and riverine environments usually coincide with phytoplankton blooms. Food poisoning caused by the consumption of fish or shellfish that feed on phycotoxins are divided into six types depending on their exerted effects: paralytic shellfish poisoning, neurotoxic shellfish poisoning, amnesic shellfish poisoning, diarrhoetic shellfish poisoning, azaspiracid poisoning, and ciguatera fish poisoning 1,2 . Domoic acid (DA) is a neurotoxin that is naturally produced by several species of phytoplankton, predominantly of the diatom genus Pseudonitzschia and Nitzschia.…”

Section: Introductionmentioning

confidence: 99%

Accumulation of domoic acid in marine organisms from Sriracha bay, Chonburi province, Thailand

Veschasit¹,

Meksumpun²,

Thawonsode³

et al. 2017

ScienceAsia

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Domoic acid (DA), a toxin produced by diatoms Pseudo-nitzschia and Nitzschia, causes amnesic shellfish poisoning. DA accumulated in marine organisms from Sriracha bay, Chonburi province, Thailand was determined from May 2012 to July 2013. Field surveys and sample collections were conducted every two months. DA content was determined using the enzyme linked immunosorbent assay (ELISA) method and ranged between not detectable and 110 ng/l for plankton. DA content in zooplankton ranged between 0.04 and 0.21 ng/l and in Perna viridis, Crassostrea lugubris, and Pinctada fucata it ranged between 214 and 454, 171 and 371, and 117 and 282 ng/g, respectively. DA content in Secutor megalolepis ranged between not detectable and 44.2 ng/g. DA was found in zooplankton, shellfish, and fish from Sriracha bay throughout the year. The amount of DA accumulation in marine organisms was lower than the regulation level (20 µg/g). Average DA content in zooplankton, shellfish, and fish throughout the year were 42%, 44%, and 5% of the DA content in phytoplankton, respectively. DA transfers from phytoplankton to zooplankton and shellfish were 7% and 8%, respectively, while transfer from zooplankton to fish was 2%.

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Environmental roles and biological activity of domoic acid: A review

Cited by 54 publications

References 119 publications

Современные Тенденции Развития Биологии Водных Экосистем

Современные Тенденции Развития Биологии Водных Экосистем

Proliferative effect of the phycotoxin domoic acid on cancer cell lines: a preliminary evaluation

Accumulation of domoic acid in marine organisms from Sriracha bay, Chonburi province, Thailand

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