Proliferative effect of the phycotoxin domoic acid on cancer cell lines: a preliminary evaluation

Ayed, Yosra; Kouidhi, Bochra; Kassim, Saba; Bacha, Hassen

doi:10.1080/16583655.2018.1451107

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…As Klf8 is an oncogene, its activation by neurotoxins may increase the risk of cancer. Indeed, Pb exposure is associated with brain cancer ( Anttila et al, 1996 ; Cocco et al, 1998 ; van Wijngaarden and Dosemeci, 2006 ), and preliminary data suggest that Domo can promote proliferation in cancer cells ( Ayed et al, 2018 ). Furthermore, because antidepressants seem to inactivate Klf8, it is possible that antidepressants may help treat brain cancers.…”

Section: Discussionmentioning

confidence: 99%

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

Talikka

Gubian

et al. 2021

Front. Genet.

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Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it is necessary to recognize the interactions of molecules, pathways, and biological processes within these networks. The developing brain is a prime example of an extremely complex network, which makes developmental neurotoxicity one of the most challenging areas in toxicology. We have developed a systems toxicology method that uses a computable biological network to represent molecular interactions in the developing brain of zebrafish larvae. The network is curated from scientific literature and describes interactions between biological processes, signaling pathways, and adverse outcomes associated with neurotoxicity. This allows us to identify important signaling hubs, pathway interactions, and emergent adverse outcomes, providing a more complete understanding of neurotoxicity. Here, we describe the construction of a zebrafish developmental neurotoxicity network and its validation by integration with publicly available neurotoxicity-related transcriptomic datasets. Our network analysis identified consistent regulation of tumor suppressors p53 and retinoblastoma 1 (Rb1) as well as the oncogene Krüppel-like factor (Klf8) in response to chemically induced developmental neurotoxicity. The developed network can be used to interpret transcriptomic data in a neurotoxicological context.

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Section: Discussionmentioning

confidence: 99%

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

Talikka

Gubian

et al. 2021

Front. Genet.

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“…Furthermore, kalkitoxin reduces calcium influx inhibition in primary rat cerebellar granule cell cultures via interacting with voltagesensitive sodium channels [125]. DA displayed proliferative effects on cancer cell lines such as K562 and EA.hy 927 in vitro [126]. STX have the potential to be used as medicines, such as anesthetics.…”

Section: Phytoplankton Toxin and Their Disease Preventing Activitiesmentioning

confidence: 99%

Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review

Pradhan

Kim

Abassi

et al. 2022

Toxins

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Phytoplankton are photosynthetic microorganisms in aquatic environments that produce many bioactive substances. However, some of them are toxic to aquatic organisms via filter-feeding and are even poisonous to humans through the food chain. Human poisoning from these substances and their serious long-term consequences have resulted in several health threats, including cancer, skin disorders, and other diseases, which have been frequently documented. Seafood poisoning disorders triggered by phytoplankton toxins include paralytic shellfish poisoning (PSP), neurotoxic shellfish poisoning (NSP), amnesic shellfish poisoning (ASP), diarrheic shellfish poisoning (DSP), ciguatera fish poisoning (CFP), and azaspiracid shellfish poisoning (AZP). Accordingly, identifying harmful shellfish poisoning and toxin-producing species and their detrimental effects is urgently required. Although the harmful effects of these toxins are well documented, their possible modes of action are insufficiently understood in terms of clinical symptoms. In this review, we summarize the current state of knowledge regarding phytoplankton toxins and their detrimental consequences, including tumor-promoting activity. The structure, source, and clinical symptoms caused by these toxins, as well as their molecular mechanisms of action on voltage-gated ion channels, are briefly discussed. Moreover, the possible stress-associated reactive oxygen species (ROS)-related modes of action are summarized. Finally, we describe the toxic effects of phytoplankton toxins and discuss future research in the field of stress-associated ROS-related toxicity. Moreover, these toxins can also be used in different pharmacological prospects and can be established as a potent pharmacophore in the near future.

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“…Conversely, although DA has poisoned humans, fish-eating birds, and marine mammals, the DA has several disease preventive actions against several deleterious diseases such as cancer [117]. DA was responsible for the natural medicine's curative effectiveness in killing parasitic worms [111], and it displayed proliferative effects on cancer cell lines such as K562 and EA.hy 927 in vitro [118]. Although little research has been conducted on the diseasepreventive effects of DA, more research is needed in order to develop a new drug molecule to combat harmful diseases in humans.…”

Section: Diatom's Toxins: the Legendary Furthest Effective Biological...mentioning

confidence: 99%

“…Yessotoxins (YTXs) are sulphated polyethers, a class of marine toxins derived from Protoceratium reticulatum, Lingulodinium polyedra, and Gonyaulax spinifera [117,118]. As a result of this property, such a toxin is regarded as one of the most polar among the otherwise lipophilic toxins [120,130].…”

Section: Dinoflagellate Toxins: the Most Prevailing Source Of Toxins ...mentioning

confidence: 99%

Phytoplankton Toxins and Their Potential Therapeutic Applications: A Journey toward the Quest for Potent Pharmaceuticals

Pradhan

2022

Marine Drugs

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Phytoplankton are prominent organisms that contain numerous bioactive substances and secondary metabolites, including toxins, which can be valuable to pharmaceutical, nutraceutical, and biotechnological industries. Studies on toxins produced by phytoplankton such as cyanobacteria, diatoms, and dinoflagellates have become more prevalent in recent years and have sparked much interest in this field of research. Because of their richness and complexity, they have great potential as medicinal remedies and biological exploratory probes. Unfortunately, such toxins are still at the preclinical and clinical stages of development. Phytoplankton toxins are harmful to other organisms and are hazardous to animals and human health. However, they may be effective as therapeutic pharmacological agents for numerous disorders, including dyslipidemia, obesity, cancer, diabetes, and hypertension. In this review, we have focused on the properties of different toxins produced by phytoplankton, as well as their beneficial effects and potential biomedical applications. The anticancer properties exhibited by phytoplankton toxins are mainly attributed to their apoptotic effects. As a result, phytoplankton toxins are a promising strategy for avoiding postponement or cancer treatment. Moreover, they also displayed promising applications in other ailments and diseases such as Alzheimer’s disease, diabetes, AIDS, fungal, bacterial, schizophrenia, inflammation, allergy, osteoporosis, asthma, and pain. Preclinical and clinical applications of phytoplankton toxins, as well as future directions of their enhanced nano-formulations for improved clinical efficacy, have also been reviewed.

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Proliferative effect of the phycotoxin domoic acid on cancer cell lines: a preliminary evaluation

Cited by 6 publications

References 22 publications

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review

Phytoplankton Toxins and Their Potential Therapeutic Applications: A Journey toward the Quest for Potent Pharmaceuticals

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