Environmental pollutants leading to carcinogenesis: process of natural selection of human cells due to chronic inflammation and sustained stress environment

Abstract

Epidemiological studies have shown that 70-90 % of all cancers are caused due to the chemicals present in environment. Exogenous exposure to carcinogens and their interaction with genetic sequences and endogenous factors, like exposures to products of metabolism which lead to acute stress, disruption of hormones and inflammation of tissues, are triggering factors. Due to relatively small risk of cancer following immediate exposure, the precise quantification of the burden of human cancer attributed to environmental exposure remains ambiguous, thereby leading to an assumption that a causal relationship is relatively large. Research suggests that 90-95 % of all cancers have their roots in the environmental effects on the DNA leading to genetic defects, whereas only 5-10 % can be attributed to inherited genetic defects. The hypothesis of the present review is that response of the cells to the environmental stimulants could be an evolutionary process of adaptation of the DNA. Carcinogenesis is considered as a process of adaptation of mammalian cells to sustained stress environment (SSE) by means of epigenetic alteration (EA) of the genome, mutations which arise due to EA and finally, natural selection of originated mutant cells evading apoptosis. Process of adaptation to SSE involves the emergence of senescent epigenetically reprogrammed cells with specific cancerrelated EA in the genome.

β-Hexachlorocyclohexane Drives Carcinogenesis in the Human Normal Bronchial Epithelium Cell Line BEAS-2B

“…On the basis of this classification, environmental contaminants represent one of the main contributors to tumor initiation, as abundantly documented by the increasing number of research studies during the past decade [ 36 ]. The list of chemical agents catalogued as carcinogenic includes the different conformers of hexachlorocyclohexane, among which stands out the well-known pesticide Lindane (γ-HCH) [ 37 ].…”

Chemical health hazards and toxicity of environmental pollutants on humans, animals and others: An overview

“…Organic herbicides (amide compounds) are more toxic to animals. Haemolysis, methemoglobinemia and immunotoxicity have occurred on experimental exposure [39].…”

Epigenetic silencing of TET1 mediated hydroxymethylation of base excision repair pathway during lung carcinogenesis

“…Lung cancer has been the most common cancer and the leading cause of cancer-related death among all patients worldwide [1]. Epidemiological studies have found that more than 80% of human lung cancers are closely related to human exposure to chemical carcinogens in living and working environments [2,3].…”